I-Linaclotide ye-Gastrointestinal Disorders 851199-59-2
Imininingwane Yomkhiqizo
| Igama | I-Linaclotide |
| Inombolo ye-CAS | 851199-59-2 |
| Ifomula yamangqamuzana | I-C59H79N15O21S6 |
| Isisindo samangqamuzana | 1526.74 |
Omqondofana
Linacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteineyl-L-cysteineyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl- I-L-prolyl-L-alanyl-L-cysteineyl-L-threonylglycyl-L-cysteineyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
Incazelo
I-Linaclotide, i-synthetic peptide structure equkethe ama-amino acid ayi-14, ihlobene nomndeni we-endogenous guanosine peptide futhi iwukuphela kwezidakamizwa ezigunyazwe yi-GC-C (guanylate) Cyclase-C) ezigunyazwe yi-FDA zokwelashwa kwe-irritable bowel syndrome ngokuqunjelwa (IBS- C) kanye nokuqunjelwa okungapheli kwe-idiopathic (CIC) kubantu abadala.
Chemical Properties
I-Linaclotide iyimpushana ye-amorphous emhlophe kuya kokumhlophe;incibilika kancane emanzini kanye nesixazululo esinamanzi se-sodium chloride (0.9%).
Isebenza kanjani
I-Linaclotide iyi-guanylate cyclase-C receptor agonist (GCCA) ene-visceral analgesic kanye nomsebenzi we-endocrine.Kokubili i-linaclotide kanye ne-metabolite yayo esebenzayo ingabopha isamukeli se-guanylate cyclase-C (GC-C) endaweni ekhanyayo ye-epithelium yamathumbu amancane.Kumamodeli ezilwane, i-linaclotide inciphisa ubuhlungu be-visceral futhi ikhuphule ukuhamba kwamathumbu ngokusebenzisa ukusebenza kwe-GC-C, futhi kubantu, umuthi ubuye ukhulise ukuhamba kwamakholoni.Umphumela wokwenza kusebenze i-GC-C ukhushulwa ukugxila kwe-intracellular kanye ne-extracellular cGMP (cyclic guanosine monophosphate).I-cGMP ye-Extracellular inganciphisa ukusebenza kwemicu yezinzwa ezibuhlungu futhi inciphise ubuhlungu be-visceral ezilwaneni eziyimodeli.I-Intracellular cGMP ingakhuphula ukukhishwa kwe-chloride ne-bicarbonate emathunjini amancane ngokwenza i-CFTR (cystic fibrosis transmembrane conductance regulator), ekugcineni iholele ekwandeni kokuphuma koketshezi lwamathumbu amancane kanye nesivinini sokuhamba kwamathumbu amancane.
FAQ
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