Liraglutide Anti-Diabetics for Blood Sugar Control CAS NO.204656-20-2 Featured Image

I-Liraglutide Anti-Diabetics for Blood Sugar Control CAS NO.204656-20-2

Incazelo emfushane:

Isithako Esisebenzayo:I-Liraglutide (i-analog ye-glucagon-like peptide-1 (GLP-1) yomuntu ekhiqizwe imvubelo ngobuchwepheshe bokuhlanganiswa kabusha kofuzo).

Igama Lekhemikhali:I-Arg34Lys26-(N-e-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]

Ezinye Izithako:I-Disodium Hydrogen Phosphate Dihydrate, i-Propylene Glycol, i-Hydrochloric Acid kanye/noma i-Sodium Hydroxide (njenge-pH Adjusters Kuphela), i-Phenol, kanye Namanzi Omjovo.

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Imininingwane Yomkhiqizo

I-CAS	204656-20-2	I-Molecular Formula	C₁₇₂H₂₆₅N₄₃O₅₁
Isisindo samangqamuzana	3751.20	Ukubukeka	Emhlophe
Isimo Sesitoreji	Ukumelana nokukhanya, i-2-8 degree	Iphakheji	Isikhwama se-aluminium foil/vial
Ubumsulwa	≥98%	Ezokuthutha	I-Cold Chain nokulethwa kwesitoreji esipholile

Izithako zeLiraglutide

Isithako Esisebenzayo:

I-Liraglutide (i-analog ye-glucagon-like peptide-1 (GLP-1) yomuntu ekhiqizwe imvubelo ngobuchwepheshe bokuhlanganiswa kabusha kofuzo).

Igama Lekhemikhali:

I-Arg34Lys26-(N-e-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]

Ezinye Izithako:

I-Disodium Hydrogen Phosphate Dihydrate, i-Propylene Glycol, i-Hydrochloric Acid kanye/noma i-Sodium Hydroxide (njenge-pH Adjusters Kuphela), i-Phenol, kanye Namanzi Omjovo.

Isicelo

Isifo sikashukela sohlobo 2

I-Liraglutide ithuthukisa ukulawulwa kweglucose yegazi.Yehlisa i-hyperglycemia ehlobene nokudla (emahoreni angama-24 ngemuva kokuphathwa) ngokwandisa ukukhiqizwa kwe-insulin (kuphela) lapho kudingwa ngokwandisa amazinga eglucose, ukubambezeleka ukuphuma kwesisu, nokucindezela ukukhiqizwa kweglucagon ye-prandial.
Ilungele iziguli ezinoshukela osegazini ongalawulwa kahle ngemuva komthamo omkhulu obekezelelwe we-metformin noma we-sulfonylureas kuphela.Isetshenziswa ngokuhlanganiswa ne-metformin noma i-sulfonylureas.
Isebenza ngendlela encike ku-glucose, okusho ukuthi izogqugquzela ukukhiqizwa kwe-insulin kuphela uma amazinga eglucose esegazini engaphezulu kokujwayelekile, kuvimbele "ukushuba ngokweqile".Ngakho-ke, kukhombisa ubungozi obuncane be-hypoglycemia.
Inamandla okuvimbela i-apoptosis futhi ikhuthaze ukukhiqizwa kabusha kwamaseli e-beta (okubonwa ezifundweni zezilwane).
Yehlisa isifiso sokudla futhi ivimbele ukukhula kwesisindo somzimba, njengoba kukhonjisiwe ocwaningweni olubhekene nekhanda nekhanda ngokumelene ne-glimepiride.

Isenzo se-Pharmacological

I-Liraglutide iyi-analog ye-GLP-1 ene-97% yokulandelana kwe-homology ku-GLP-1 yomuntu, engabopha futhi yenze i-GLP-1 receptor isebenze.I-GLP-1 receptor iyimpoqo ye-GLP-1 yomdabu, i-endogenous incretin hormone ekhuthaza ukukhiqizwa kwe-insulin encike ekugxilweni kweglucose kumaseli e-pancreatic beta.Ngokungafani ne-GLP-1 yomdabu, amaphrofayili e-pharmacokinetic kanye ne-pharmacodynamic e-liraglutide kubantu alungele uhlobo lomthamo kanye ngosuku.Ngemuva komjovo we-subcutaneous, indlela yayo yokwenza isikhathi eside ihlanganisa: ukuzihlanganisa okubambezela ukumuncwa;ukubopha ku-albumin;Ukuqina kwe-enzyme ephezulu futhi ngaleyo ndlela ende yesigamu sempilo ye-plasma.

Umsebenzi we-liraglutide uqondiswa ukuxhumana kwayo okukhethekile ne-GLP-1 receptor, okuholela ekwandeni kwe-cyclic adenosine monophosphate (cAMP).I-Liraglutide ivuselela ukukhiqizwa kwe-insulin ngendlela encike ekugxilweni kwe-glucose, kuyilapho yehlisa ukukhiqizwa kwe-glucagon ngokweqile ngendlela encike ekugxilweni kweglucose.

Ngakho-ke, lapho ushukela wegazi ukhuphuka, ukukhiqizwa kwe-insulin kuyavuselelwa, kuyilapho ukukhiqizwa kwe-glucagon kuvinjelwe.Ngokuphambene, i-liraglutide yehlisa ukukhiqizwa kwe-insulin ngesikhathi se-hypoglycemia ngaphandle kokuthinta ukukhiqizwa kwe-glucagon.Indlela ye-hypoglycemic ye-liraglutide ihlanganisa nokwelulwa kancane kwesikhathi sokuphuma kwesisu.I-Liraglutide yehlisa isisindo somzimba kanye nesisindo samafutha omzimba ngokunciphisa indlala nokudla kwamandla.

Okwedlule:

Olandelayo: I-Trimethylstearylammonium Chloride 112-03-8

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