Ganirelix Acetate Peptide API Featured Image

I-Ganirelix Acetate Peptide API

Incazelo emfushane:

Igama: Ganirelix Acetate

Inombolo ye-CAS: 123246-29-7

Ifomula yemolekyuli: C80H113ClN18O13

Isisindo se-molecule: 1570.34

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Imininingwane Yomkhiqizo

Igama	I-Ganirelix Acetate
Inombolo ye-CAS	123246-29-7
Ifomula yamangqamuzana	I-C80H113ClN18O13
Isisindo samangqamuzana	1570.34

Omqondofana

I-Ac-DNal-DCpa-DPal-Ser-Tyr-DHr(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate;I-GANIRELIX;I-Ganirelix Acetate USP/EP/

Incazelo

I-Ganirelix iyinhlanganisela ye-decapeptide yokwenziwa, futhi usawoti wayo we-acetate, i-Ganirelix acetate iyi-gonadotropin-releasing hormone (GnRH) receptor antagonist.Ukulandelana kwe-amino acid kuthi: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro- I-D- Ala-NH2.Ikakhulukazi ngokomtholampilo, isetshenziswa kwabesifazane abathola usizo lobuchwepheshe bokuzala izinhlelo zokuvuselela i-ovarian ukuvimbela ukuphakama kwe-hormone ye-luteinizing ngaphambi kwesikhathi kanye nokwelapha ukuphazamiseka kwenzalo ngenxa yalesi sizathu.Umuthi unezici zokusabela okuncane okubi, izinga eliphezulu lokukhulelwa kanye nesikhathi sokwelashwa esifushane, futhi unezinzuzo ezisobala uma kuqhathaniswa nezidakamizwa ezifanayo ekusebenzeni komtholampilo.

Isenzo se-Pharmacological

Ukukhululwa kwe-pulsatile kwe-gonadotropin-releasing hormone (GnRH) kukhuthaza ukuhlanganiswa nokukhishwa kwe-LH ne-FSH.Imvamisa ye-LH pulses phakathi nesigaba se-follicular sekwephuzile cishe i-1 ngehora.Lawa ma-pulses abonakala ekukhuphukeni kwesikhashana kwe-serum LH.Phakathi nesikhathi sokuya esikhathini, ukukhululwa okukhulu kwe-GnRH kubangela ukwanda kwe-LH.Ukuhlinzwa kwe-LH okuphakathi nokuya esikhathini kungabangela izimpendulo ezithile zomzimba, okuhlanganisa: ukukhishwa kwamaqanda, ukuqaliswa kabusha kwe-oocyte meiotic, nokwakheka kwe-corpus luteum.Ukwakhiwa kwe-corpus luteum kubangela ukuthi amazinga e-serum progesterone akhuphuke, kuyilapho amazinga e-estradiol ehla.I-Ganirelix acetate iyimbangi ye-GnRH evimbela ngokuncintisana ama-GnRH receptors kuma-pituitary gonadotrophs nezindlela zokudlulisela ezilandelayo.Ikhiqiza ukuvinjelwa okusheshayo, okubuyisela emuva ukukhiqizwa kwe-gonadotropin.Umthelela ovimbelayo we-ganirelix acetate ekukhiqizweni kwe-pituitary LH wawunamandla kunalowo ku-FSH.I-Ganirelix acetate yehlulekile ukunxenxa ukukhululwa kokuqala kwe-gonadotropin engapheli, ehambisana nokuphikisana.Ukutholwa okuphelele kwamazinga e-pituitary LH ne-FSH kwenzeke phakathi namahora angu-48 ngemva kokuba i-ganirelix acetate iyekwa.

Okwedlule: I-Cetrorelix Acetate yokuvimbela i-Ovulation ngaphambi kwesikhathi 120287-85-6

Olandelayo: I-Linaclotide ye-Gastrointestinal Disorders 851199-59-2

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