Igama | I-Semaglutide |
Inombolo ye-CAS | 910463-68-2 |
Ifomula yamangqamuzana | I-C187H291N45O59 |
Isisindo samangqamuzana | 4113.57754 |
Inombolo ye-EINECS | 203-405-2 |
I-Sermaglutide;I-Semaglutide fandachem;ukungcola kwe-Semaglutide;I-Sermaglutide USP/EP;i-semaglutide;I-Sermaglutide CAS 910463 68 2;Ozempic,
I-Semaglutide iyisizukulwane esisha se-GLP-1 (i-glucagon-like peptide-1) analogues, kanti i-semaglutide iyindlela yomthamo ethatha isikhathi eside eyakhiwe ngokususelwa esakhiweni esiyisisekelo se-liraglutide, esinomthelela ongcono ekwelapheni uhlobo 2 lwesifo sikashukela.I-Novo Nordisk isiqedile izifundo ze-6 Phase IIIa zomjovo we-semaglutide, futhi yahambisa isicelo esisha sokubhaliswa kwezidakamizwa ngomjovo wamasonto onke we-semaglutide ku-US Food and Drug Administration (FDA) ngo-December 5, 2016. Isicelo sokugunyazwa kwezokumaketha (MAA) sithunyelwe futhi i-European Medicines Agency (EMA).
Uma kuqhathaniswa ne-liraglutide, i-semaglutide inochungechunge olude lwe-aliphatic kanye nokwanda kwe-hydrophobicity, kodwa i-semaglutide iguqulwa ngeketanga elifushane le-PEG, futhi i-hydrophilicity yayo ithuthukiswa kakhulu.Ngemuva kokuguqulwa kwe-PEG, ayikwazi nje kuphela ukubopha eduze kwe-albumin, ukumboza indawo ye-enzymatic hydrolysis ye-DPP-4, kodwa futhi yehlise ukukhishwa kwezinso, yelule isigamu sempilo yebhayoloji, futhi ifinyelele umphumela wokujikeleza isikhathi eside.
I-Semaglutide iyifomu lomthamo osebenza isikhathi eside elakhiwe ngokususelwa esakhiweni esiyisisekelo se-liraglutide, esisebenza ngempumelelo ekwelapheni isifo sikashukela sohlobo 2.
I-Semaglutide (Rybelsus, Ozempic, NN9535, OG217SC, NNC0113-0217) iyi-analog esebenza isikhathi eside efana ne-glucagon-like peptide 1 (GLP-1), i-agonist ye-GLP-1receptor, enekhono lokwelapha lohlobo 2 lwesifo sikashukela (TDM mellitus) ).
Sekukonke, uhlelo lwekhwalithi kanye nesiqiniseko sikhona esihlanganisa zonke izigaba zokukhiqiza umkhiqizo osuphelile.Imisebenzi eyanele yokukhiqiza nokulawula yenziwa ngokuhambisana nezinqubo/izimiso ezigunyaziwe.Ukulawulwa koshintsho kanye nohlelo lokusingatha ukuchezuka sekukhona, futhi ukuhlolwa komthelela okudingekile nophenyo lwenziwa.Kunezinqubo ezifanele zokuqinisekisa ikhwalithi yomkhiqizo ngaphambi kokukhishelwa emakethe.