I-Lilaclotide ye-Gastrointestinal Disortrers 851199-59-2 Okufakiwe Isithombe

I-Lilaclotide ye-Gastrointestinal Disorders 851199-59-2

Incazelo emfushane:

Igama: uLinaclotide

Inombolo ye-CAS: 851199-59-2

Ifomula ye-molecular: c59h79n15o21s6

Isisindo molecular: 1526.74

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Imininingwane Yomkhiqizo

Ibizo	Lilaclotide
Inombolo ye-CAS	851199-59-2
Ifomula yamangqamuzana	C59h79n15o211s6
Isisindo molecular	1526.74

Amanyanjana

Ilacllotide; i-linaclotide; i-linalotideacetate; i-linalotide; cy-14; i-lichlorin; -L-cysteinyl-L-cystelinel-l-asparaginyl-L-Prolyl-L-Cystell-L-strenell-L-Threenyl-L-Threenyl-L-Threell-L-Threell-L-Three

Ukufanisa

ILinaclotide, isakhiwo sokwenziwa se-peptide esiqukethe ama-amino acid ayi-14, sihlobene nomndeni we-maanosine we-endoGenous GC-C (Guaclate) i-Cyclase-c) Ukuqunjelwa kwe-Idiopathic ye-Idiopathic (IBS-C) kanye nokuqunjelwa kwabantu abadala.

Izakhiwo Zamakhemikhali

ILilaclotide ingumbala omhlophe ophumeleli-omhlophe; incibilika kancane emanzini ne-aquoud sodium chloride solution (0.9%).

Isebenza kanjani

I-Linaclotide yi-yaclate cyclase-c receptor agonist (GCCA) nayo yomibili imisebenzi ye-visceral analgesic ne-endocrine. Kokubili i-linaclotide ne-metabolite yayo esebenzayo ingabopha i-yacclate cyclase-C (GC-C) receptor emugqeni we-luminal we-epithelium encane yamathumbu. Kumamodeli wezilwane, iLinaclotide inciphisa izinhlungu ze-visceral futhi yandisa ukuhamba kwe-gastrointestinal ngokwenza kusebenze i-GC-C, nakubantu, isidakamizwa futhi sandisa ukuhamba kwe-colonic. Umphumela we-GC-C activation unyuke kakhulu we-CGMP e-intracellular ne-externacelic (i-cyclic Guanosine monophosphate) ukugxila. I-ExtraceLellar CGMP inganciphisa umsebenzi wezinzwa zezinzwa yezinzwa futhi inciphise izinhlungu ze-visceral ezilwaneni eziyimodeli. I-Intraacellular CGMP ingakhuphula ukutholakala kwe-chloride kanye ne-bicarbonate emathunjini amancane ngokwenza i-CFTR (Cystic Fibrosis Transmembrane Ruterance Regulator), okugcina kuholela ekwandeni kwama-fluid amathumbu amathumbu akhuphukayo kanye nejubane lokuhamba okuncane kwamathumbu.

Umthandi

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