I-Linaclotide ye-Gastrointestinal Disorders 851199-59-2
Imininingwane Yomkhiqizo
| Igama | I-Linaclotide |
| Inombolo ye-CAS | 851199-59-2 |
| Ifomula yamangqamuzana | I-C59H79N15O21S6 |
| Isisindo samangqamuzana | 1526.74 |
Omqondofana
Linacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteineyl-L-α-glutamyl-L-tyrosyl -L-cysteineyl-L-cysteineyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteineyl-L-threonylglycyl-L-cysteineyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
Incazelo
I-Linaclotide, ukwakheka kwe-peptide yokwenziwa equkethe ama-amino acid ayi-14, ihlobene nomndeni we-endogenous guanosine peptide futhi ukuphela kwezidakamizwa ezigunyazwe i-GC-C (guanylate) Cyclase-C) ze-GC-C (guanylate) Cyclase-C) ezigunyazwe yi-FDA zokwelashwa kwe-irritable bowel syndrome nokuqunjelwa (IBS-C) kanye nokuqunjelwa okungapheli kwe-idiopathic (CIC).
Chemical Properties
I-Linaclotide iyimpushana ye-amorphous emhlophe kuya kokumhlophe; incibilika kancane emanzini kanye nesisombululo esinamanzi se-sodium chloride (0.9%).
Isebenza kanjani
I-Linaclotide iyi-guanylate cyclase-C receptor agonist (GCCA) ene-visceral analgesic kanye nomsebenzi we-endocrine. Kokubili i-linaclotide ne-metabolite yayo esebenzayo ingabopha isamukeli se-guanylate cyclase-C (GC-C) endaweni ekhanyayo ye-epithelium yamathumbu amancane. Kumamodeli ezilwane, i-linaclotide inciphisa ubuhlungu be-visceral futhi ikhuphule ukuhamba kwamathumbu ngokusebenzisa ukusebenza kwe-GC-C, futhi kubantu, umuthi ubuye ukhulise ukuhamba kwe-colon. Umphumela wokwenza kusebenze i-GC-C ukhushulwa ukugxila kwe-intracellular kanye ne-extracellular cGMP (cyclic guanosine monophosphate). I-cGMP ye-Extracellular inganciphisa umsebenzi wezintambo zenzwa yobuhlungu futhi inciphise ubuhlungu be-visceral ezilwaneni eziyimodeli. I-Intracellular cGMP ingakhuphula ukukhishwa kwe-chloride ne-bicarbonate emathunjini amancane ngokwenza i-CFTR (cystic fibrosis transmembrane conductance regulator), ekugcineni iholele ekwandeni kokuphuma koketshezi lwamathumbu amancane kanye nesivinini sokuhamba kwamathumbu amancane.
FAQ
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