I-Terlipressin Acetate Yokopha Kwe-Esophageal Variceal
Imininingwane Yomkhiqizo
| Igama | N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin |
| Inombolo ye-CAS | 14636-12-5 |
| Ifomula yamangqamuzana | I-C52H74N16O15S2 |
| Isisindo samangqamuzana | 1227.37 |
| Inombolo ye-EINECS | 238-680-8 |
| Iphuzu elibilayo | 1824.0±65.0 °C (Kubikezelwe) |
| Ukuminyana | 1.46±0.1 g/cm3(Kubikezelwe) |
| Izimo zokugcina | Gcina endaweni emnyama, endaweni epholile, Gcina efrijini, ngaphansi kuka-15°C. |
| I-acidity coefficient | (pKa) 9.90±0.15 (Kubikezelwe) |
Omqondofana
[N-α-Triglycyl-8-lysine]-vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein; I-1-Triglycyl-8-lysineVasopressin; I-Nα-Glycyl-glycyl-glycyl--[8-lysine]-vasopressin; I-Nα-Glycyl-glycyl-glycyl-lysine-vasopressin; I-Nα-Glycylglycylglycyl-vasopressin; I-Nα-Gly-Gly-Gly-8-Lys-vasopressin; I-Terlipressin, i-Terlipressine, i-Terlipressina, i-Terlipressinum.
Incazelo
I-Terlipressin, igama layo lamakhemikhali elithi triglycyllysine vasopressin, iyilungiselelo elisha lokwenziwa le-vasopressin elisebenza isikhathi eside. Iwuhlobo lwe-prodrug, engasebenzi iyodwa. Kwenziwa i-aminopeptidase ku-vivo "ukukhulula" kancane kancane i-lysine vasopressin esebenzayo ngemva kokukhipha izinsalela ezintathu ze-glycyl ku-N-terminus yayo. Ngakho-ke, i-terlipressin isebenza njengechibi elikhipha i-lysine vasopressin ngenani eliqinile.
Umphumela we-pharmacological we-terlipressin uwukufinyezwa kwemisipha ebushelelezi yemithambo ye-splanchnic nokunciphisa ukugeleza kwegazi kwe-splanchnic (njengokunciphisa ukugeleza kwegazi ku-mesentery, i-spleen, isibeletho, njll.), ngaleyo ndlela kuncishiswe ukugeleza kwegazi e-portal kanye nomfutho we-portal. Ngakolunye uhlangothi, kunganciphisa futhi i-plasma Umphumela wokugxila kwe-renin, ngaleyo ndlela ukhulise ukugeleza kwegazi kwezinso, uthuthukise umsebenzi wezinso futhi ukhuphule ukuphuma komchamo ezigulini ezine-hepatorenal syndrome. I-Terlipressin okwamanje ukuphela komuthi ongathuthukisa izinga lokusinda leziguli ezinokopha kwe-variceal esophageal. Yayisetshenziswa ikakhulukazi ekwelapheni komtholampilo we-variceal hemorrhage. Ngaphezu kwalokho, i-terlipressin nayo isetshenziswe ngempumelelo esibindini nasezinso. Ngokuvamile, kungenzeka kudlale indima enenzuzo ekubambisaneni kwe-refractory shock kanye nokuvuselelwa kwe-cardiopulmonary. Uma kuqhathaniswa ne-vasopressin, inomphumela ohlala isikhathi eside, ayibangeli izinkinga eziyingozi, kuhlanganise ne-fibrinolysis kanye nezinkinga ezingathi sína ohlelweni lwenhliziyo nemithambo yegazi, futhi kulula ukuyisebenzisa (umjovo we-intravenous), ofaneleka kakhulu ukunakekelwa okubucayi nokubucayi. Ukuhlenga nokwelashwa kweziguli ezigula kakhulu.
