I-Terligressin Acetate ye-Esophageal Variceal Bloing
Imininingwane Yomkhiqizo
| Ibizo | N- (n-glycylllylylylyl) -8-l-l-lysinevasopressin |
| Inombolo ye-CAS | 14636-12-5-5 |
| Ifomula yamangqamuzana | C52H74N16O15S2 |
| Isisindo molecular | 1227.37 |
| Inombolo ye-einec | 238-680-8 |
| Iphuzu elibilayo | Ngo-1824.0 ± 65.0 ° C (wabikezela) |
| Incekusana | 1.46 ± 0.1 g / cm3 (ukubikezelwa) |
| Izimo Zokugcina | Gcina endaweni emnyama, umkhathi we-inert, esitolo efrijini, ngaphansi -15 ° C. |
| I-acidity coccifflity | (PKA) 9.90 ± 0.15 (Ebikezelwe) |
Amanyanjana
[N-α-triglycyl-8-lysine] -Vasopressin; 130: PN: WO2010033207SEQID: 171clayEdproten; I-1-triglycyl-8-lysinevasopressin; Nα-glycyl-glycyl-glycyl- [8-lysine] -Velsressin; I-Nα-glycyl-glycyl-glycyl-lysine-vasopressin; Nα-glycylllycyllyclyclyclycycyclycyclen; Α-gly-gly-gly-8-Lys-vasopressin; I-Terligressin, i-terlipressine, i-terligressina, i-terligressinum.
Ukufanisa
I-Terligressin, i-TriglyCyllysine Vasopressin, uhlelo olusha lweVasopressin olusebenza isikhathi eside lwe-vasopressin. Kuluhlobo lwe-prodrug, olungasebenzi ngokwalo. Kwenziwe nge-aminopeptidase eVivo ukuyokwehla kancane "ukukhulula" i-lysine vasopressin ngemuva kokususa izinsalela ezintathu ze-glycyl e-N-terminus yayo. Ngakho-ke, i-TerlipMiryin isebenza njenge-reservoir ekhipha i-lysine vasopressin ngesilinganiso esiqinile.
Umphumela we-motormacological we-terligressin ukukhokhela izicubu ze-splanchnic vascular abushelelezi futhi unciphise ukugeleza kwegazi le-splanchnic (njengokunciphisa ukugeleza kwegazi ku-mesentery, i-spleen, i-uters, njll. Ngakolunye uhlangothi, kunganciphisa futhi i-plasma umphumela weRenin okuhlushwa, ngaleyo ndlela ikhuphuke ukugeleza kwegazi kwe-renal, ngcono ukusebenza kwe-renal kanye nokukhulisa umchamo okhulayo ezigulini ezine-heparenal syndrome. I-Terligressin okwamanje ukuphela kwezidakamizwa ezingathuthukisa izinga lokusinda kweziguli ezine-esophageal vaviceal hemorrhage. Kwakusetshenziswa ikakhulukazi ekwelashweni kwemitholampilo kwe-variceal hemorrhage. Ngaphezu kwalokho, iTerlipMisIn isetshenziswe ngempumelelo esibindini nasezinso. Ngokuvamile, kungenzeka ukuthi badlale indima ezuzisayo ekuvuseleleni kabusha ukuthuthumela kokushaqeka nokuvuselelwa kwenhliziyo. Uma kuqhathaniswa ne-vasopressin, inomphumela ohlala isikhathi eside, ayibangeli izinkinga eziyingozi, kufaka phakathi i-fibrinolysis kanye nezinkinga ezinkulu ohlelweni lwenhliziyo, futhi kulula ukuyisebenzisa (i-intravenous umjovo), okulungele ukunakekelwa okunamandla nokubucayi. Ukuhlenga nokwelashwa kweziguli ezigula kakhulu.
