I-Eptifibatide yokwelashwa kwe-Acute Coronary Syndrome 188627-80-7
Imininingwane Yomkhiqizo
| Igama | I-Eptifibatide |
| Inombolo ye-CAS | 188627-80-7 |
| Ifomula yamangqamuzana | I-C35H49N11O9S2 |
| Isisindo samangqamuzana | 831.96 |
| Inombolo ye-EINECS | 641-366-7 |
| Ukuminyana | 1.60±0.1 g/cm3(Kubikezelwe) |
| Izimo zokugcina | Ivalwe endaweni eyomile, igcinwe efrijini, ngaphansi kuka-15°C |
Omqondofana
I-Eptifibatideacetatesalt;Eptifibatide,MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2,MPAHARGDWPC-NH2,>99%;MAP-LYS-GLY-ASP-TRP-PRO-CYS-NH2;INTEGRELIN;Eptifibatide;N6- (I-Aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl-L-lysylglycyl-La-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide;MPA-HAR-GLY-ASP-TRP-PRO-CYS-NH2 (DISULFIDEBRIDGE,MPA1-CYS6).
I-Platelet Glycoprotein Antagonist
I-Etifibatide (i-integrilin) iyinoveli ye-polypeptide platelet glycoprotein IIb/IIIa receptor antagonist, evimbela ukuhlangana kweplatelet kanye ne-thrombosis ngokuvimbela indlela yokugcina evamile yokuhlangana kweplatelet.Uma iqhathaniswa ne-monoclonal antibody abciximab, i-eptifibatide inokubopha okuqinile, okuqondisayo nokuqondile ku-GPIIb/IIIa ngenxa yokuba khona kokushintshwa okukodwa kwe-amino acid elondolozayo—i-lysine ukuze ithathe indawo ye-arginine.Ngakho-ke, kufanele kube nomphumela omuhle wokwelapha ekwelashweni kokungenelela kwe-acute coronary syndrome.Izidakamizwa eziphikisana ne-Platelet glycoprotein IIb/IIIa sezithuthukiswe kakhulu, futhi okwamanje kunezinhlobo ezi-3 zamalungiselelo angasetshenziswa emitholampilo yamazwe ngamazwe, i-abciximab, i-eptifibatide ne- tirofiban.).Kunokuhlangenwe nakho okuncane ekusetshenzisweni kwe-platelet glycoprotein GPIIb/IIIa abaphikisi be-receptor e-China, futhi izidakamizwa ezitholakalayo nazo zilinganiselwe kakhulu.Muthi owodwa kuphela, i- tirofiban hydrochloride, emakethe.Ngakho-ke, kwasungulwa i-platelet glycoprotein IIb entsha./IIIa ama-receptor antagonists abalulekile.I-Domestic eptifibatide iwumkhiqizo wokulingisa okhiqizwe yi-Chengdu Sino Biological Products Co., Ltd.
Ukwahlukanisa
Ukuhlukaniswa Kwezidakamizwa Zokuhlanganisa I-Antiplatelet
Izidakamizwa zokuhlanganisa i-Antiplatelet zingahlukaniswa cishe zibe izigaba ezintathu: 1. Ama-Cyclooxygenase-1 (COX-1) inhibitors, njenge-aspirin.2. Vimbela ukuhlanganiswa kwe-platelet okubangelwa i-adenosine diphosphate (ADP), njenge-clopidogrel, i-prasugrel, i-cangrelor, i-ticagrelor, njll. i-prostaglandin EP3 receptor inhibitors, izingxenye zamakhemikhali ezisanda kuhlanganiswa kanye nezingcaphuno ezisebenzayo ezivela emithini yendabuko yamaShayina.
