I-Leuprorelin Acetate Ilawula Ukugcinwa Kwama-Gonadal Hormones
Imininingwane Yomkhiqizo
| Igama | I-Leuprorelin |
| Inombolo ye-CAS | 53714-56-0 |
| Ifomula yamangqamuzana | I-C59H84N16O12 |
| Isisindo samangqamuzana | 1209.4 |
| Inombolo ye-EINECS | 633-395-9 |
| Ukuzungezisa okuqondile | I-D25 -31.7° (c = 1 ku-1% i-acetic acid) |
| Ukuminyana | 1.44±0.1 g/cm3(Kubikezelwe) |
| Isimo sesitoreji | -15°C |
| Ifomu | Kucocekile |
| I-acidity coefficient | (pKa) 9.82±0.15 (Kubikezelwe) |
| Ukuncibilika kwamanzi | Incibilika emanzini ngo-1mg/ml |
Omqondofana
LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(HUMAN);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEMONE-LUTEN; I-DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-ISIFIKISO SOKUKHISHWA;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(HUMAN)
Umphumela we-Pharmacological
I-Leuprolide, i-goserelin, i-triprelin, ne-nafarelin yizidakamizwa ezimbalwa ezivame ukusetshenziswa emtholampilo ukuze kukhishwe ama-ovari ukuze zelashwe umdlavuza webele wangaphambi kokuya esikhathini kanye nomdlavuza wendlala yesinye.(okubizwa ngokuthi izidakamizwa ze-GnRH-a), izidakamizwa ze-GnRH-a ziyafana ngesakhiwo se-GnRH futhi zincintisana nama-pituitary GnRH receptors.Okusho ukuthi, i-gonadotropin ekhiqizwe yi-pituitary iyancipha, okuholela ekwehleni okuphawulekayo kwe-hormone yocansi ekhishwa yi-ovary.
I-Leuprolide iyi-analog ye-gonadotropin-releasing hormone (GnRH), i-peptide eyakhiwe ngama-amino acid ayi-9.Lo mkhiqizo ungavimbela ngokuphumelelayo ukusebenza kwesistimu ye-pituitary-gonadal, ukumelana nama-enzyme e-proteolytic kanye nokuhlotshaniswa ne-pituitary GnRH receptor kunamandla kune-GnRH, futhi umsebenzi wokugqugquzela ukukhululwa kwe-luteinizing hormone (LH) cishe izikhathi ezingu-20 kwe-GnRH.Iphinde ibe nomthelela onamandla wokuvimbela umsebenzi we-pituitary-gonad kune-GnRH.Esigabeni sokuqala sokwelashwa, i-follicle stimulating hormone (FSH), LH, estrogen noma i-androgen ingakhushulwa okwesikhashana, bese kuthi, ngenxa yokuncipha kokusabela kwe-pituitary gland, ukugcinwa kwe-FSH, LH ne-estrogen noma i-androgen kuvinjelwe, okuholela ekuthembeleni kumahomoni ocansi.Izifo zocansi (ezifana nomdlavuza wendlala yesinye, i-endometriosis, njll.) zinomphumela wokwelapha.
Njengamanje, usawoti we-acetate we-leuprolide usetshenziswa kakhulu emtholampilo, ngoba ukusebenza kwe-leuprolide acetate kuzinzile ekamelweni lokushisa.Uketshezi kufanele kulahlwe.Ingasetshenziselwa ukwelashwa kokuthenwa kwezidakamizwa kwe-endometriosis kanye ne-uterine fibroids, ukuthomba okuphakathi, umdlavuza webele we-premenopausal kanye nomdlavuza wendlala yesinye, kanye nokopha okusebenzayo kwesibeletho okuphikisiwe noma okungasebenzi ekwelapheni okujwayelekile kwama-hormone.Ingasetshenziswa futhi njenge-premedication ngaphambi kokukhishwa kwe-endometrial, okungase kube mncane ngokulinganayo i-endometrium, kunciphise i-edema, futhi kunciphise ubunzima bokuhlinzwa.
