Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage Featured Image

I-Carbetocin Yokuvimbela Ukufinyela Kwesibeletho kanye Nokopha Kwangemva Kokubeletha

Incazelo emfushane:

Igama: CARBETOCIN

Inombolo ye-CAS: 37025-55-1

Ifomula yemolekyuli: C45H69N11O12S

Isisindo se-molecule: 988.17

Inombolo ye-EINECS: 253-312-6

Ukuphenduka okuqondile: D -69.0° (c = 0.25 ku-1M acetic acid)

Indawo yokubilisa: 1477.9±65.0 °C (Kubikezelwe)

Ukuminyana: 1.218±0.06 g/cm3(Kubikezelwe)

Izimo zokugcina: -15°C

Ifomu: powder

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Imininingwane Yomkhiqizo

Igama	I-CARBETOCIN
Inombolo ye-CAS	37025-55-1
Ifomula yamangqamuzana	I-C45H69N11O12S
Isisindo samangqamuzana	988.17
Inombolo ye-EINECS	253-312-6
Ukuzungezisa okuqondile	D -69.0° (c = 0.25 ku-1M acetic acid)
Iphuzu elibilayo	1477.9±65.0 °C (Kubikezelwe)
Ukuminyana	1.218±0.06 g/cm3(Kubikezelwe)
Izimo zokugcina	-15°C
Ifomu	impushana

Omqondofana

I-BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBODBETWEENBUTYL-4-YLANDCYS);I-BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT;(BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT;(BUTYRYL1, TYR(ME)2)-OXYTOCIN;(BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT;I-CARBETOCIN;I-CARBETOCINTRIFLUOROACETATESALT;(2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN

Umsebenzi webhayoloji

I-Carbetocin, i-oxytocin (OT) analog, iyi-oxytocin receptor agonist ene-Ki ye-7.1 nM.I-Carbetocin inokuhambisana okuphezulu (Ki=1.17 μM) ye-chimeric N-terminus ye-oxytocin receptor.I-Carbetocin inamandla ocwaningo lokopha kwangemva kokubeletha.I-Carbetocin ingangena kusithiyo sobuchopho begazi futhi ibe nomsebenzi ofana ne-antidepressant ngokwenza kusebenze ama-oxytocin receptors ku-CNS.

Umsebenzi

I-Carbetocin iyi-analog ye-oxytocin 8-peptide esebenza isikhathi eside esebenza isikhathi eside enezici ze-agonist, futhi izici zayo zomtholampilo nezemithi ziyafana nalezo ze-oxytocin eyenzeka ngokwemvelo.Njenge-oxytocin, i-carbetocin ibophezela kuma-hormone receptors emisipha ebushelelezi yesibeletho, okubangela ukufinyela okunesigqi kwesibeletho, okwandisa ukuvama kwayo nokwandisa ithoni yesibeletho ngesisekelo sokufinyela kwasekuqaleni.Amazinga e-Oxytocin receptor esibelethweni aphansi esimweni esingakhulelwe, ayanda ngesikhathi sokukhulelwa, futhi aphakeme ngesikhathi sokubeletha.Ngakho-ke, i-carbetocin ayinawo umthelela esibelethweni esingakhulelwe, kodwa inomphumela onamandla wenkontileka yesibeletho esibelethweni esikhulelwe kanye nesibeletho esisanda kukhiqizwa.

Shintsha Izilawuli

Izinguquko zilawulwa ngokwenqubo.Ngokusekelwe kumthelela kanye nobungozi kanye nobukhulu, izinguquko zihlukaniswa njengezinkulu, ezincane kanye neSiza.Izinguquko zesayithi zinomthelela omncane ekuphepheni nakwikhwalithi yomkhiqizo, ngakho-ke azidingi imvume nesaziso kukhasimende;Izinguquko ezincane zinomthelela omaphakathi ekuphepheni nakwikhwalithi yomkhiqizo, futhi zidinga ukwazisa ikhasimende;Izinguquko ezinkulu zinomthelela ophezulu ekuphepheni nakwikhwalithi yomkhiqizo, futhi zidinga ukugunyazwa yikhasimende.

Ngokwenqubo, ukulawulwa koshintsho kuqalwa ngohlelo lokusebenza loshintsho lapho kuchazwa imininingwane yoshintsho nokunengqondo koshintsho.Ukuhlola kube sekwenziwa ngokulandela isicelo, okwenziwa yiminyango efanele yokulawula ushintsho.Ngaleso sikhathi, isilawuli sokushintsha sihlukaniswa ngokwezinga elikhulu, izinga elijwayelekile kanye nezinga Elincane.Ngemva kokuhlola okufanele kanye nokuhlukaniswa, konke ukulawulwa koshintsho lwezinga kufanele kuvunywe Umphathi we-QA.Ukulawulwa koshintsho kwenziwa ngemva kokugunyazwa ngokohlelo lwesenzo.Ukulawulwa koshintsho kuvalwa ekugcineni ngemuva kokuthi i-QA iqinisekisa ukuthi isilawuli sokushintsha senziwe ngendlela efanele.Uma kuhlanganisa nesaziso seklayenti, iklayenti kufanele laziswe kusenesikhathi ngemva kokugunyazwa kokulawulwa koshintsho

Okwedlule: I-Atosiban Acetate Isetshenziselwa Ukuzalwa Okungakabi Isikhathi

Olandelayo: I-Cetrorelix Acetate yokuvimbela i-Ovulation ngaphambi kwesikhathi 120287-85-6

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