I-Carbetocin ukuvikela ukuqondiswa kwesibeletho kanye ne-postpartum hemorrhage
Imininingwane Yomkhiqizo
| Ibizo | Carbetocin |
| Inombolo ye-CAS | 37025-55-1 |
| Ifomula yamangqamuzana | C4hh69N11o12s |
| Isisindo molecular | 988.1.17 |
| Inombolo ye-einec | 253-312-6 |
| Ukujikeleza okuthile | D -69.0 ° (c = 0.25 ku-1m acetic acid) |
| Iphuzu elibilayo | 1477.9 ± 65.0 ° C (wabikezela) |
| Incekusana | I-1.218 ± 0.06 g / cm3 (ebikezelwe) |
| Izimo Zokugcina | -15 ° C |
| Isithunzi | impushana |
Amanyanjana
I-Butyryl-Tyr (Me) -I-Gy-Asn-Asn-Asn-Asn-Cys-Pro-Leu-Gly-NH2, (sulfidebondbetbetbetbetweenButryrl-4-Yardcys); I-Butyryl-Tyr (Me) -I-GL-ASN-ASN-ASN-CYS-Pro-Leu-Gly-NH2TRIFLUOOROACALLTALLT; (Butterryl1, Tyr (Me) 2) -1-Carbaoxytoc intrifluoroatetalt; (Butyryl1, tyr (me) 2)--Oxytocin; (Butterryl1, tyr (me) 2) -Uku -oxytocintrifluoroaltalt; Carbetocin; Carbetococintrifluoroatetalt; (2-o-methyltyrosine) -De-amino-1-carbaoxytocin
Umsebenzi wemvelo
I-Carbetocin, i-oxytocin (OT) Analog, iyi-agonist ye-oxytocin receptor ene-Ki ye-7.1 NM. I-Carbetocin inobudlelwano obuphezulu (Ki = 1.17 μm) ye-Chimeric N-terminus ye-Oxetocin Receptor. I-Carbetocin inamandla okucwaninga nge-postpartum hemorrhage. I-Carbetocin ingangena emgodleni wegazi-ubuchopho futhi inomsebenzi ofana ne-antideressured ngokwenza i-oxytocin receptocin kuma-CNS.
Sebenza
I-Carbetocin iyi-oxytocin esebenza isikhathi esezingeni eliphakeme ye-oxetocin 8 Njenge-Oxetocin, i-Carbetocin ibopha kuma-receptone e-uterine abushelelezi, abangele ukuxhaswa kwezigqila zesibeletho, ukukhulisa imvamisa yalo kanye nokukhulisa ithoni yesibeletho ngesisekelo sezivumelwano zangempela. Amazinga we-Oxetocin Receptor esibelethweni aphansi esimweni esingewona akhulelwe, anda ngesikhathi sokukhulelwa, futhi aphezulu ngesikhathi sokubeletha. Ngakho-ke, i-Carbetocin ayinamthelela kwi-Utersus engakhulelwe, kepha inomthelela onamandla we-Uterine Confine we-Utersus okhulelwe kanye nesibeletho esanda kukhiqizwa.
Shintsha izilawuli
Izinguquko zilawulwa ngokuya ngenqubo. Ngokusekelwe kumthelela kanye nobungozi nobunzima, izinguquko zihlukaniswa njengezikhulu, ezincane kanye nesayithi. Izinguquko zesayithi zinomthelela omncane ekuphepheni nasezingeni lomkhiqizo, ngakho-ke awudingi ukuvunywa nokwazisa ikhasimende; Izinguquko ezincane zinomthelela olinganiselayo ngokuphepha kanye nekhwalithi yomkhiqizo, futhi kudingeka ukwazise ikhasimende; Izinguquko ezinkulu zinomthelela ophakeme ngokuphepha nekhwalithi yomkhiqizo, futhi udinga ukuvunywa yikhasimende.
Ngokwenqubo, ukuguqulwa kolawulo kuqalwa ngohlelo lokusebenza lokushintsha lapho kuchazwa imininingwane yokushintsha futhi kunengqondo ukuthi ushintsho luchazwa. Ukuhlolwa kulandelwa ngemuva kohlelo lokusebenza, olusususwa ngokushintsha iminyango efanelekile. Okwamanje, ukulawulwa kokushintsha kuhlukaniswa ngezinga elikhulu, izinga elijwayelekile kanye nezinga elincane. Ngemuva kokuhlolwa okufanele kanye nokuhlukaniswa, wonke amazinga okuguqula izinga kufanele avunyelwe yi-QA Manager. Ukulawulwa kokushintsha kwenziwa ngemuva kokuvunywa ngokohlelo lwesenzo. Ukulawulwa kokushintsha ekugcineni kuvaliwe ngemuva kokuthi i-QA iqinisekisa ukuthi ukulawulwa kokushintsha kwenziwe ngokufanele. Uma kubandakanya isaziso seklayenti, iklayenti kufanele liziswe ngesikhathi ngemuva kokuvunyelwa kokushintsha okuvunyelwe
