I-Ganirelix Acetate Peptide API

Incazelo emfushane:

Igama: Ganirelix Acetate

Inombolo ye-CAS: 123246-29-7

Ifomula ye-molecular: c80h113cln18o13

Isisindo samangqamuzana: 1570.34

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Imininingwane Yomkhiqizo

Ibizo	Ganirelix acetate
Inombolo ye-CAS	123246-29-7
Ifomula yamangqamuzana	C80h113cln18o13
Isisindo molecular	1570.34

Amanyanjana

I-AC-DNAL-DNPA-DPAL-SER-TRY-DRR-DRR-DHAR (ET2) -Leu-Har (ET2) -PRO-DALA -NH2; I-Ganirelix Acetate; UGanirelix; Ganirelix acetate USP / EP /

Ukufanisa

IGanirelix iyingxenye yokwenziwa ye-demopeptide, futhi usawoti wayo we-acetate, i-ganirelix acetate yi-gonadotropin-edeasing hormone (GNRH) i-receptor antambathast. Ukulandelana kwe-Amino Acid kuyinto: AC-D-4NAL-D-4CPA-D-3PAL-SER-TRY-D-TOMOARGG (9,10-ET2) -Lu-l-Homoarg (9,10-ET2) -Pro-D- Ala-NH2. Ikakhulukazi ngokomphakathi, isetshenziswa kwabesifazane ababhekene nobuchwepheshe bokuzala obulawulwa ngokulawulwa kwezikhuthazo zokuvuselela iziqu zokuvuselela iziqongo ze-hormone kanye nokwelapha izinkinga zokuzala ngenxa yalokhu. Lesi sidakamizwa sinezimpawu zokungaphendulwa kabi okuncane, isilinganiso esiphakeme sokukhulelwa kanye nesikhathi esifushane sokwelashwa, futhi sinezinzuzo ezisobala uma kuqhathaniswa nezidakamizwa ezifanayo ekusebenzeni kwemitholampilo.

Isenzo samakhemisi

Ukukhishwa kwe-pulsatile kwe-gonadotropin-ukukhulula ama-hormone (GNRH) kuvuselela ukuhlanganiswa kanye nokufihlakala kwe-lh no-Fsh. Imvamisa ye-LH PUlses maphakathi nezigaba ze-Follular sekwephuzile cishe i-1 ngehora. Lawa ma-pulses aboniswa ku-Transient ekhuphuka eSerum Lh. Ngesikhathi sokuya esikhathini, ukukhishwa okukhulu kwe-GNRH kubangela ukuhlinzwa kwe-LH. Ukuhlinzwa kwe-LH Midmenscrual kungadala izimpendulo eziningana zomzimba, kufaka phakathi: ukuqalwa kabusha kwe-ovulation, i-Oocyte Meiotic Recation, kanye nokwakheka kweCorpus Lutem. Ukwakheka kwe-corpus luteum kubangela amazinga e-serum progesterone ukukhuphuka, ngenkathi amazinga e-estradiol ewa. I-Ganirelix Acetate yi-GNRH ANVANISSITY EBONAKALAYO EQHAWULA IZIBHALO ZAMABHODI AMAHNRH ePituitary Gonadotrophs kanye Nezindlela Zokudlulisa Ezilandelayo. Ikhiqiza ukuvimbela okusheshayo, okuguqukayo kwe-Gonadotropin Secreion. Umphumela wokuvimbela e-Ganithelix Acetate ku-Putuitary LH Secreetion wawunamandla kunalokho ku-FSH. IGanirelix Acetate yehlulekile ukunxenxa ukukhishwa kokuqala kwama-gonadotropins e-endogenous, ahambisana nokuphikisana. Ukuvuselelwa okuphelele kwamazinga e-pituitary lh namazinga we-FSh kwenzeka kungakapheli amahora angama-48 ngemuva kokunqanyulwa kwe-ganirelix acetate.

Okwedlule: I-CETRORELIX ACETATE ukuvikela i-ovulation yangaphambi kwesikhathi 120287-85-6

Olandelayo: I-Lilaclotide ye-Gastrointestinal Disorders 851199-59-2

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