I-Desmopressin Acetate Ukwelapha i-Diabetes Insipidus ephakathi
Imininingwane Yomkhiqizo
| Igama | I-Desmopressin |
| Inombolo ye-CAS | 16679-58-6 |
| Ifomula yamangqamuzana | I-C46H64N14O12S2 |
| Isisindo samangqamuzana | 1069.22 |
| Inombolo ye-EINECS | 240-726-7 |
| Ukuzungezisa okuqondile | I-D25 +85.5 ± 2° (ibalelwe i-peptide yamahhala) |
| Ukuminyana | 1.56±0.1 g/cm3(Kubikezelwe) |
| RTECS No. | YW9000000 |
| Izimo zokugcina | Gcina ku-0°C |
| Ukuncibilika | I-H2O: i-soluble20mg/mL, icacile, ayinambala |
| I-acidity coefficient | (pKa) 9.90±0.15 (Kubikezelwe) |
Omqondofana
I-MPR-TYR-PHE-GLN-ASN-CYS-PRO-D-ARG-GLY-NH2; I-MINIRIN; [DEAMINO1, DARG8] I-VASOPRESSIN; [DEAMINO-CYS1, D-ARG8]-VASOPRESSIN; I-DDAVP, UMUNTU; I-DESMOPRESSIN; DESMOPRESSIN, UMUNTU; DESAMINO-[D-ARG8] VASOPRESSIN
Izinkomba
(1) Ukwelashwa kwesifo sikashukela i-insipidus. Ngemuva kokuthi umuthi unganciphisa ukuphuma komchamo, unciphise imvamisa yomchamo futhi unciphise i-nocturia.
(2) Ukwelashwa kwe-enuresis yasebusuku (iziguli ezineminyaka engu-5 noma ngaphezulu).
(3) Hlola umsebenzi wokuhlushwa komchamo wezinso, futhi wenze ukuhlonza okuhlukile kokusebenza kwezinso.
(4) Nge-hemophilia nezinye izifo zokopha, lo mkhiqizo unganciphisa isikhathi sokopha futhi uvimbele ukopha. Kunganciphisa inani lokulahleka kwegazi kwe-intraoperative kanye nokuphuma ngemuva kokuhlinzwa; ikakhulukazi ngokuhambisana nomfutho wegazi olawulwa ngokunengqondo phakathi nokuhlinzwa, kunganciphisa ukopha kwangaphakathi kokuhlinzwa okuvela ezindleleni ezihlukene, futhi kunciphise ukuvuza kwangemva kokuhlinzwa, okungadlala indima engcono ekuvikelweni kwegazi.
Ukwelashwa kwesifo sikashukela i-insipidus
Isifo sikashukela i-insipidus ngokuyinhloko ukuphazamiseka kwe-metabolism yamanzi ebonakala ngokuphuma komchamo oweqile, i-polydipsia, i-hypoosmolarity, ne-hypernatremia. Ukuntuleka kwe-vasopressin okuyingxenye noma okuphelele (i-central diabetes insipidus), noma ukungasebenzi kahle kwezinso kwe-vasopressin (nephrogenic diabetes insipidus) kungase kuqale. Ngokomtholampilo, isifo sikashukela i-insipidus sifana ne-polydipsia eyinhloko, isimo lapho ukuphuza uketshezi ngokweqile kubangelwa ukungasebenzi kahle kwendlela yokulawula noma ukoma okungavamile. Ngokuphambene ne-polydipsia eyinhloko, ukwanda komthamo wamanzi ezigulini ezinesifo sikashukela i-insipidus kuyimpendulo ehambisanayo nezinguquko zomfutho we-osmotic noma umthamo wegazi.
