I-Atosiban Acetate Isetshenziselwa Ukuzalwa Okungakabi Isikhathi
Imininingwane Yomkhiqizo
| Igama | Atosiban |
| Inombolo ye-CAS | 90779-69-4 |
| Ifomula yamangqamuzana | I-C43H67N11O12S2 |
| Isisindo samangqamuzana | 994.19 |
| Inombolo ye-EINECS | 806-815-5 |
| Iphuzu elibilayo | 1469.0±65.0 °C (Kubikezelwe) |
| Ukuminyana | 1.254±0.06 g/cm3(Kubikezelwe) |
| Izimo zokugcina | -20°C |
| Ukuncibilika | I-H2O:≤100 mg/mL |
Incazelo
I-Atosiban acetate iyi-polypeptide ye-cyclic ehlanganiswe ne-disulfide ehlanganisa ama-amino acid ayi-9. Kuyi-molecule ye-oxytocin eguquliwe ezindaweni 1, 2, 4 kanye no-8. I-N-terminus ye-peptide yi-3-mercaptopropionic acid (thiol kanye neqembu le-sulfhydryl le- [Cys] 6 lakha ibhondi ye-disulfide), i-C-terminal isesimweni se-amide, i-amino acid yesibili i-D-terminal e-D-terminal i-D-terminal futhi i-atosiban acetate isetshenziswa emithini njengoviniga Ikhona ngesimo sikasawoti omuncu, owaziwa kakhulu nge-atosiban acetate.
Isicelo
I-Atosiban iyi-oxytocin kanye ne-vasopressin V1A ehlanganisiwe ye-receptor antagonist, i-oxytocin receptor ifana nesakhiwo se-vasopressin V1A receptor. Uma i-oxytocin receptor ivinjiwe, i-oxytocin isengakwazi ukusebenza ngesamukeli se-V1A, ngakho-ke kuyadingeka ukuvimba izindlela ezimbili zama-receptor ezingenhla ngesikhathi esisodwa, futhi ukuphikiswa okukodwa kwesamukeli esisodwa kunganqanda ngempumelelo ukufinyela kwesibeletho. Lesi futhi esinye sezizathu eziyinhloko zokuthi kungani ama-β-receptor agonists, i-calcium channel blockers kanye ne-prostaglandin synthase inhibitors engakwazi ukuvimbela ngokuphumelelayo ukufinyela kwesibeletho.
Umphumela
I-Atosiban iyisitha esihlanganisiwe se-receptor ye-oxytocin ne-vasopressin V1A, ukwakheka kwayo kwamakhemikhali kufana nalokhu okubili, futhi inobudlelwane obuphezulu be-receptors, futhi iqhudelana ne-oxytocin ne-vasopressin V1A receptors, ngaleyo ndlela ivimbe indlela yesenzo se-oxytocin ne-vasopressin nokunciphisa ukufinyela kwesibeletho.
