I-Atosiban Acetate esetshenziselwa ukuzalwa ngaphambi kwesikhathi
Imininingwane Yomkhiqizo
| Ibizo | Atosiban |
| Inombolo ye-CAS | 90779-69-4 |
| Ifomula yamangqamuzana | C43h67N11o1212S2 |
| Isisindo molecular | 994.19 |
| Inombolo ye-einec | 806-815-5-5 |
| Iphuzu elibilayo | 1469.0 ± 65.0 ° C (wabikezela) |
| Incekusana | I-1.254 ± 0.06 g / cm3 (ebikezelwe) |
| Izimo Zokugcina | -20 ° C |
| Ubuhlakaniselo | I-H2O: ≤100 MG / ML |
Ukufanisa
I-Atosiban Acetate iyi-polyckide ye-cyclide ye-disclide ehlanganisa ama-amino acid ayi-9. I-molecule eguquliwe ye-oxytocin ezikhundleni 1, 2, 4 no-8. I-n-terminus ye-peptide yi-3-hlangana kanye ne-sulfhydry group atide, i-C-Amino acid ekhefini ye-N-terminal ku-ebifinal elungisiwe [I-D-TRY (ET)] 2, futhi i-atosiban acetate isetshenziswa emithini njengoba uviniga ukhona ngendlela kasawoti we-acid, owaziwa ngokuthi i-atosiban acetate.
Isicelo
I-Atosiban yi-oxetocin kanye ne-vasopressin v1a ehlangene ne-receptor antaltist, i-oxytocin receptor ifana ne-vasopressin v1a receptor. Lapho i-oxytocin receptor ivinjiwe, i-oxetocin isengasebenza nge-v1a receptor, ngakho-ke kuyadingeka ukuvimba le migwaqo emibili engenhla ngasikhathi sinye, futhi ukuphambana okukodwa kwe-receptor eyodwa kungavimba ngempumelelo ukuthengiswa kwe-uterine. Lokhu futhi kungenye yezizathu eziphambili zokuthi kungani ama-agep e-β-receptor agonists, ama-calcium Channel blockers nama-synthase synthase avimba ama-inhibitors awakwazi ukuvimba ngempumelelo amandla okubeletha.
Umphumela
I-Atosiban yi-anagetsor ehlanganisiwe ye-oxytocin ne-vasopressin v1a, isakhiwo sayo samakhemikhali sifana nalawo ma-receptors, futhi sinezinkinga ze-oxytocin kanye ne-vasopressin kanye ne-vasopressin kanye nokunciphisa izivumelwano zesibeletho.
