I-Tesamorelin

I-Tesamorelin API

I-Tesamorelin iyisidakamizwa se-peptide yokwenziwa, igama eligcwele yi-ThGRF(1-44)NH₂, okuyi-hormone yokukhula ekhulula i-hormone (GHRH) analog. Ishukumisa i-anterior pituitary ukuze ikhiphe i-hormone yokukhula (GH) ngokulingisa isenzo se-GHRH engapheli, ngaleyo ndlela ikhulise ngokungaqondile izinga le-insulin-like growth factor 1 (IGF-1), ilethe uchungechunge lwezinzuzo kumetabolism kanye nokulungiswa kwezicubu.

Njengamanje, i-Tesamorelin ivunyelwe yi-FDA yokwelashwa kwe-lipodystrophy ehlobene ne-HIV, ikakhulukazi ekunciphiseni ukuqoqwa kwamafutha e-visceral esiswini (izicubu ze-visceral adipose, i-VAT). Kuye kwacwaningwa kabanzi nge- **anti-aging, metabolic syndrome, isifo sesibindi esinamafutha angenalo utshwala (NAFLD/NASH)** kanye neminye imikhakha, ebonisa amathemba okufaka isicelo abanzi.
Indlela yokwenza

I-Tesamorelin iyi-peptide ye-44-amino acid enesakhiwo esifana kakhulu ne-GHRH yemvelo. Indlela yokusebenza yayo yile:

Yenza kusebenze i-GHRH receptor (GHRHR) ukuze ushukumise i-anterior pituitary ukuthi ikhulule i-GH.

Ngemuva kokuthi i-GH iphakanyisiwe, isebenza esibindi nezicubu ezizungezile ukuze kwandiswe i-IGF-1 synthesis.

I-GH ne-IGF-1 ngokubambisana babamba iqhaza ku-fat metabolism, amaprotheni synthesis, ukulungiswa kwamaseli kanye nokugcinwa kwamathambo.

Isebenza kakhulu ekuwohlokeni kwamafutha e-visceral (ukuhlanganisa amafutha) futhi inomthelela omncane kumafutha angaphansi kwesikhumba.

Uma kuqhathaniswa nomjovo oqondile we-GH, i-Tesamorelin ikhuthaza ukugcinwa kwe-GH ngokusebenzisa izindlela ezingapheli, eziseduze nesigqi somzimba futhi igwema ukusabela okubi okubangelwa i-GH ngokweqile, njengokugcinwa kwamanzi nokumelana ne-insulin.

Ucwaningo kanye nempumelelo yomtholampilo

Ukusebenza kwe-Tesamorelin kuqinisekiswe ngezivivinyo eziningi zemitholampilo, ikakhulukazi kulezi zindawo ezilandelayo:

1. I-lipodystrophy ehlobene ne-HIV (izinkomba ezigunyazwe yi-FDA)

I-Tesamorelin inganciphisa kakhulu i-VAT yesisu (isilinganiso sokuncipha kwe-15-20%);

Khulisa amazinga e-IGF-1 futhi uthuthukise isimo somzimba womzimba;

Thuthukisa isimo somzimba futhi unciphise umthwalo ongokwengqondo ohambisana nokwabiwa kabusha kwamafutha;

Ayithinti kakhulu ungqimba lwamafutha angaphansi kwesikhumba, ukuminyana kwamathambo noma imisipha.

2. I-steatohepatitis engeyona utshwala (NASH) kanye ne-fibrosis yesibindi

Ukuhlolwa kwemitholampilo kubonise ukuthi i-Tesamorelin inganciphisa okuqukethwe kwamafutha esibindi (imaging ye-MRI-PDFF);

Kulindeleke ukuthi kuthuthukiswe ukuzwela kwe-insulin ye-hepatocyte;

Isebenza kakhulu ezigulini ezine-HIV ne-NAFLD, futhi inokuvikelwa okungaba khona kwe-broad-spectrum metabolism.

3. I-Metabolic syndrome kanye nokumelana ne-insulin

I-Tesamorelin inciphisa kakhulu amazinga e-triglyceride nokukhuluphala kwesisu;

Ithuthukisa inkomba ye-HOMA-IR futhi isiza ekuthuthukiseni ukumelana ne-insulin;

Ucwaningo luye lwabonisa ukuthi lungathuthukisa amandla e-muscle amaprotheni synthesis, okuzuzisa asebekhulile noma ukululama kwezifo ezingapheli.

Ukukhiqizwa kwe-API nokulawulwa kwekhwalithi

I-Tesamorelin API ehlinzekwa yi-Gentolex Group yethu isebenzisa ubuchwepheshe obuthuthukisiwe besigaba se-peptide synthesis (SPPS) futhi ikhiqizwa ngaphansi kwemvelo ye-GMP. Inezici ezilandelayo:

Ubumsulwa ≥99% (HPLC)
Ayikho i-endotoxin, insimbi esindayo, ukutholwa kwe-solvent eyinsalela efanelekile
Ukulandelana kwe-amino acid nokuqinisekiswa kwesakhiwo nge-LC-MS/NMR
Nikeza ukukhiqizwa okwenziwe ngendlela oyifisayo kuleveli yegremu kuya kwekhilogremu