Semaglutide for daidotes kashukela 2
Imininingwane Yomkhiqizo
| Ibizo | Semullutide |
| Inombolo ye-CAS | 910463-68-6 |
| Ifomula yamangqamuzana | C18hh291n45o59 |
| Isisindo molecular | 4113.57754 |
| Inombolo ye-einec | 203-405-2 |
Amanyanjana
I-Sermalbutide; Semarlutide fandachem; Ukungcoliswa kweSemaglutide; I-Sermaglutide USP / EP; Semarlutide; Sermaglutide CAC 910463 68; Ozempic,
Ukufanisa
I-Semaglutide yisizukulwane esisha se-glp-1 (i-glucagon-efana ne-peptide-1) ama-analog athatha umthamo wamathamo omude athuthukiswa asuselwa kwisakhiwo esiyisisekelo se-liraglutide, esinomphumela ongcono ekwelashweni kwesifo soshukela 2. UNovo Nordisk uqedele izifundo ezi-6 zesigaba IIII yomjovo weSemaglutide, futhi wathumela isicelo esisha sokulungiswa kwezidakamizwa sangaphambi kokudla kwamasonto e-US Food and Drug Administration (2016.
Uma kuqhathaniswa ne-liraglutide, i-semaglutide ine-aliphatic chain ende futhi yandise i-hydrophopobicity, kepha i-semaglutive iguqulwa ngochungechunge olufushane lwe-PEG, futhi i-hydrophility yayo ithuthukiswa kakhulu. Ngemuva kokuguqulwa kwe-PEG, akunakukwazi ukubopha kuphela ku-albhamuin, amboze indawo ye-enzymatic hydrolysis ye-DPP-4, kepha futhi anciphise ukukhishwa kwe-renal, anwebe impilo yemvelo, futhi afinyelele umphumela wokujikeleza kwemvelo, futhi afinyelele umphumela wokujikeleza kwebhayoloji, futhi afinyelele umphumela wokujikeleza kwendabuko, futhi afinyelele umphumela wokujikeleza kwendabuko.
Isicelo
I-Semaglutide yifomu lokuthatha umthamo olingene isikhathi eside elakhiwa ngesakhiwo esiyisisekelo seLiraglutide, ephumelela kakhudlwana ekwelapheni uhlobo lwesifo sikashukela sohlobo 2.
Ukumangalisa
Semaglutide (Rybelsus, Ozempic, NN9535, OG217SC, NNC0113-0217) I-Analog-1recep yase-GLP
Uhlelo lwekhwalithi
Ngokuvamile, uhlelo lwekhwalithi kanye nesiqinisekiso selusendaweni ehlanganisa lonke isigaba sokukhiqizwa komkhiqizo ophelile. Ukusebenza okwanele nokulawula ukusebenza kwenziwa ngokuhambisana nezinqubo / imininingwane evunyelwe. Ukushintsha kolawulo kanye nokuphambuka kohlelo kusendaweni, futhi kwenziwa ukuhlolwa komthelela kanye nophenyo. Izinqubo ezifanele zisendaweni yokuqinisekisa ikhwalithi yomkhiqizo ngaphambi kokuyikhipha emakethe.
