Pulegone

I-Pulegone API

I-Pulegone (ifomula yamangqamuzana: C₁₀H₁₆O) iyinhlanganisela ye-monoterpene ketone etholakala kumafutha abalulekile esitshalo semvelo, atholakala kakhulu ku-mint (Mentha), i-verbena (i-Verbena) nezitshalo ezihlobene. Njengesithako semvelo esinephunga elimnandi nomsebenzi ophezulu wezinto eziphilayo, uPulegone uthole ukunakwa okubanzi emkhakheni wemithi yemvelo, izibulala-zinambuzane zezitshalo, amakhemikhali asebenzayo nsuku zonke kanye nezinto zokusetshenziswa kwemithi eminyakeni yamuva nje.

I-Pulegone API esiyihlinzekayo iyinhlanganisela ehlanzekile etholakala ngenqubo ephumelelayo yokuhlukanisa nokuhlanza, ehlangabezana nezindinganiso zekhwalithi yamabanga emithi noma yezimboni futhi ifanele ukusetshenziswa okuhlukahlukene njengocwaningo lwesayensi nokuthuthukiswa kanye nokuhlanganisa okuphakathi.

Isizinda socwaningo kanye nemiphumela yezemithi

1. Umphumela wokulwa nokuvuvukala

Inani elikhulu lezilwane nezifundo zokuhlola amangqamuzana lithole ukuthi i-Pulegone ingavimbela ukukhululwa kwezinto ezithinta ukuvuvukala (ezifana ne-TNF-α, IL-1β ne-IL-6), ilawula izindlela zokubonisa i-COX-2 ne-NF-κB, futhi ngaleyo ndlela ibonise amandla amakhulu okulwa nokuvuvukala kumamodeli wezifo ezifana ne-rheumatoid arthritis nokuvuvukala kwesikhumba.
2. Imiphumela ye-analgesic kanye ne-sedative

I-Pulegone inomphumela othile ovimbelayo ohlelweni lwezinzwa olumaphakathi futhi ikhombisa umphumela osobala we-analgesic kumamodeli ezilwane. Indlela yayo ingase ihlobane nokulawulwa kwesistimu ye-neurotransmitter ye-GABA. Inamandla okusetshenziswa njengokwelashwa kwe-adjuvant yokukhathazeka okuncane noma ubuhlungu be-neuropathic.
3. Umsebenzi we-antibacterial kanye ne-antifungal

I-Pulegone inemiphumela evimbelayo ezinhlobonhlobo zamabhaktheriya e-Gram-positive kanye ne-Gram-negative, njenge-Staphylococcus aureus, i-Escherichia coli, i-Bacillus subtilis, njll; futhi ikhombisa ikhono lokuvimbela isikhunta esifana ne-Candida albicans ne-Aspergillus, futhi ifaneleka ukuthuthukiswa kwezivimbelakuvunda zemvelo kanye nemikhiqizo esekelwe ezitshalweni elwa namagciwane.
4. Umsebenzi wokuxosha izinambuzane nowokubulala izinambuzane

Ngenxa yomphumela wayo ovimbelayo ohlelweni lwezinzwa zezinambuzane, i-Pulegone isetshenziswa kakhulu emithi yemvelo exosha izinambuzane, ekwazi ukuxosha ngokuphumelelayo omiyane, izibungu, izimpukane zezithelo, njll., futhi inokuhambisana okuhle kwemvelo kanye nokubola kwezinto eziphilayo.
5. Umsebenzi ongase ube khona wokulwa nesimila (ucwaningo lokuqala)

Ucwaningo lokuqala luye lwabonisa ukuthi i-Pulegone ingase ibe nomthelela ovimbelayo kwamanye amangqamuzana e-tumor (njengamaseli omdlavuza webele) ngokufaka i-apoptosis, elawula ukucindezeleka kwe-oxidative nokusebenza kwe-mitochondrial, njll.
Izinkambu zohlelo lokusebenza nemiphumela elindelekile
●Imboni yezemithi

Njenge-molecule eholayo yemvelo ekuthuthukisweni kwezidakamizwa, i-Pulegone ingasetshenziswa njengendawo ephakathi ukuze ibambe iqhaza ekuhlanganiseni kwe-menthol (Menthol), i-menthone, izithasiselo zokunambitheka kanye nemithi emisha engase ibe yi-anti-inflammatory kanye ne-antibacterial. Inamathemba abanzi okusebenza ekwenziweni kwesimanje kwemithi yendabuko yamaShayina kanye namalungiselelo emithi yemvelo.
●Izimonyo namakhemikhali nsuku zonke

Ngephunga layo elimnandi nomsebenzi we-antibacterial, i-Pulegone isetshenziselwa ukulungisa imilomo yemvelo, i-mouthwash, i-antiseptic wash, izifutho ze-mite, imikhiqizo yokuxosha omiyane, njll., ukuze kuhlangatshezwane nesidingo semakethe samakhemikhali ansuku zonke aluhlaza, anokucasuka kancane, naphephile kakhulu.
●Ezolimo kanye nezinto ezixosha izinambuzane ezingayingeni imvelo

I-Pulegone, njengesithako semvelo sokubulala izinambuzane, isetshenziselwa ukuthuthukisa izibulala-zinambuzane ezisekelwe esitshalweni ezidingekayo kwezolimo eziphilayo, ukunciphisa ukungcoliswa kwemvelo, ukuthuthukisa ikhwalithi yezitshalo, nokuhambisana nesu lokuthuthukiswa kwezolimo esimeme.
Ukuzibophezela kwekhwalithi yeGentolex Group

I-Pulegone API enikezwe i-Gentolex Group yethu ineziqinisekiso zekhwalithi ezilandelayo:

Ukuhlanzeka okuphezulu: ubumsulwa ≥99%, bufanele ukusetshenziswa kwezemithi kanye nezimboni eziphezulu

Ihambisana ne-GMP kanye nezidingo zesistimu yokuphatha ikhwalithi ye-ISO

Nikeza ngemibiko yokuhlolwa kwekhwalithi ebanzi (i-COA, ehlanganisa ukuhlaziywa kwe-GC/HPLC, izinsimbi ezisindayo, izincibilikisi eziyinsalela, imikhawulo ye-microbial)

Ukucaciswa okwenziwe ngokwezifiso kunganikezwa ngokuya ngezidingo zekhasimende, ukuhlinzeka okusekelayo kusuka kumagremu kuya kumakhilogremu