Imikhiqizo

I-High Purity Peptides Retatrutide 10mg yokuncipha kwesisindo kanye nesifo sikashukela

Ubumsulwa: >99%

Isimo: I-Lyophilized Powder

Ukubukeka: Impushana emhlophe

Ukucaciswa: 5mg/10mg/15mg/20mg/30mg

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I-Retatrutide

I-Retaglutide iyisidakamizwa esisha se-dipeptidyl peptidase-4 (DPP-4) inhibitor class hypoglycemic engavimbela ukuwohloka kwe-glucagon-like peptide-1 (GLP-1) kanye ne-glucose encike ku-insulin-ekhulula i-polypeptide (GIP) nge-enzyme ye-DPP-4 emathunjini nasegazini, ngokwandisa umsebenzi wabo we-insulin, ngokwandisa umsebenzi wabo we-pancreas. Izinga eliyisisekelo le-insulin yokuzila, kuyilapho kunciphisa ukukhiqizwa kwe-glucagon ngamaseli e-pancreatic α, ngaleyo ndlela kulawule ngempumelelo ushukela wegazi we-postprandial. Isebenza kahle ngokuya ngomphumela we-hypoglycemic, ukubekezelelana, nokuhambisana.

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I-Inclisiran sodium

I-Inclisiran sodium API (I-Active Pharmaceutical Ingredient) ifundwa ngokuyinhloko emkhakheni we-RNA interference (RNAi) kanye nokwelapha kwenhliziyo nemithambo yegazi. Njenge-siRNA enemicu ephindwe kabili eqondise isakhi sofuzo se-PCSK9, isetshenziswa ocwaningweni lwangaphambi kwezempilo nolwezempilo ukuze kuhlolwe amasu asebenza isikhathi eside okuthulisa ufuzo okwehlisa i-LDL-C (low-density lipoprotein cholesterol). Iphinde isebenze njengenhlanganisela yemodeli yokuphenya izinhlelo zokulethwa kwe-siRNA, ukuzinza, kanye nemithi yokwelapha ye-RNA eqondiswe esibindini.

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I-Fmoc-Gly-Gly-OH

I-Fmoc-Gly-Gly-OH iyi-dipeptide esetshenziswa njengebhlokhi yokwakha eyisisekelo ku-solid-phase peptide synthesis (SPPS). Ifaka izinsalela ezimbili ze-glycine kanye ne-Fmoc-protected N-terminus, evumela ukwelulwa kweketango le-peptide elilawulwayo. Ngenxa yobukhulu obuncane be-glycine nokuguquguquka, le dipeptide ivame ukufundwa kumongo we-peptide backbone dynamics, ukwakheka kwe-linker, kanye nokumodela kwesakhiwo kuma-peptide namaprotheni.

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I-Fmoc-Thr(tBu)-Phe-OH

I-Fmoc-Thr(tBu)-Phe-OH iyibhulokhi yokwakha ye-dipeptide evame ukusetshenziswa ku-solid-phase peptide synthesis (SPPS). Iqembu le-Fmoc (9-fluorenylmethyloxycarbonyl) livikela i-N-terminus, kuyilapho iqembu le-tBu (tert-butyl) livikela iketango laseceleni le-hydroxyl le-threonine. Le dipeptide evikelwe icwaningwa ngendima yayo ekusizeni ukunwetshwa kwe-peptide okusebenzayo, ekwehliseni ukugqama kwe-racemization, kanye nokwenza imodeli ye-motif elandelanayo ethile ekwakhekeni kwamaprotheni nezifundo zokusebenzisana.

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AEEA-AEEA

I-AEEA-AEEA iyi-hydrophilic, i-spacer eguquguqukayo evame ukusetshenziswa ocwaningweni lwe-peptide nokuhlanganiswa kwezidakamizwa. Iqukethe amayunithi amabili asekelwe ku-ethylene glycol, okwenza kube usizo ekutadisheni imiphumela yobude besixhumanisi nokuguquguquka ekusebenzisaneni kwamangqamuzana, ukunyibilika, kanye nomsebenzi webhayoloji. Abacwaningi bavame ukusebenzisa amayunithi e-AEEA ukuhlola ukuthi ama-spacers athonya kanjani ukusebenza kwama-antibody-drug conjugates (ADCs), ama-peptide-drug conjugates, namanye ama-bioconjugates.

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I-Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Le nhlanganisela iyi-derivative ye-lysine evikelwe, esebenzayo esetshenziswa ekuhlanganiseni kwe-peptide nasekuthuthukisweni kwe-conjugate yezidakamizwa. Ihlanganisa iqembu le-Fmoc lokuvikela i-N-terminal, kanye nokuguqulwa kwe-side-chain nge-Eic(OtBu) (i-eicosanoic acid derivative), γ-glutamic acid (γ-Glu), kanye ne-AEEA (aminoethoxyethoxyacetate). Lezi zingxenye zenzelwe ukutadisha imiphumela ye-lipidation, i-spacer chemistry, nokukhululwa kwezidakamizwa okulawulwayo. Icwaningwa kabanzi kumongo wamasu we-prodrug, izixhumanisi ze-ADC, nama-peptide asebenzisana nolwelwesi.

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I-Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Le nhlanganisela iwukuphuma kwe-lysine eguquliwe esetshenziswa ku-peptide synthesis, ikakhulukazi ekwakheni ama-conjugates e-peptide ahlosiwe noma asebenzayo. Iqembu le-Fmoc livumela ukuhlanganiswa kwesinyathelo ngesinyathelo nge-Fmoc solid-phase peptide synthesis (SPPS). Iketango elisemaceleni lilungiswa ngokuphuma kwe-stearic acid (Ste), γ-glutamic acid (γ-Glu), nezixhumi ezimbili ze-AEEA (aminoethoxyethoxyacetate), ezihlinzeka nge-hydrophobicity, izakhiwo zokushaja, nesikhala esivumelana nezimo. Ivamise ukufundelwa indima yayo ezinhlelweni zokulethwa kwezidakamizwa, okuhlanganisa ama-antibody-drug conjugates (ADCs) kanye nama-peptide angena kumaseli.

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I-Liraglutide Anti-Diabetics for Blood Sugar Control CAS NO.204656-20-2

Isithako Esisebenzayo:I-Liraglutide (i-analog ye-glucagon-like peptide-1 (GLP-1) yomuntu ekhiqizwa imvubelo ngobuchwepheshe bokuhlanganiswa kabusha kofuzo).

Igama Lekhemikhali:I-Arg34Lys26-(N-e-(γ-Glu(N-α-hexadecanoyl)))-GLP-1[7-37]

Ezinye Izithako:I-Disodium Hydrogen Phosphate Dihydrate, i-Propylene Glycol, i-Hydrochloric Acid kanye/noma i-Sodium Hydroxide (njenge-pH Adjusters Kuphela), i-Phenol, Namanzi Omjovo.

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I-Leuprorelin Acetate Ilawula Ukugcinwa Kwama-Gonadal Hormones

Igama: Leuprorelin

Inombolo ye-CAS: 53714-56-0

Ifomula yemolekyuli: C59H84N16O12

Isisindo se-molecule: 1209.4

Inombolo ye-EINECS: 633-395-9

Ukujikeleza okuqondile: D25 -31.7° (c = 1 ku-1% i-acetic acid)

Ukuminyana: 1.44±0.1 g/cm3(Kubikezelwe)

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I-Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

I-Boc-His(Trt)-Aib-Gln(Trt)-Gly-OHiyi-tetrapeptide evikelwe esetshenziswa ku-peptide synthesis kanye nezifundo zesakhiwo. Iqembu le-Boc (tert-butyloxycarbonyl) livikela i-N-terminus, kuyilapho amaqembu e-Trt (trityl) avikela amaketanga aseceleni e-histidine ne-glutamine ukuze avimbele ukusabela okungafunwa. Ukuba khona kwe-Aib (α-aminoisobutyric acid) kukhuthaza ukuhlangana kwe-helical futhi kuthuthukise ukuzinza kwe-peptide. Le peptide ibalulekile ekuphenyeni ukugoqeka kwe-peptide, ukuzinza, nanjengesikafula sokuklama ama-peptide asebenza ngokwebhayoloji.

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I-BPC-157

I-BPC-157 API yamukela inqubo yesigaba esiqinile (SPPS):
Ukuhlanzeka okuphezulu: ≥99% (ukutholwa kwe-HPLC)
Izinsalela zokungcola okuphansi, akukho endotoxin, akukho ukungcoliswa kwensimbi esindayo
Ukuzinza kweqoqo, ukuphindaphinda okuqinile, ukusetshenziswa kwezinga lomjovo lokusekela
Sekela ukunikezwa kwezinga legram nekhilogremu ukuze kuhlangatshezwane nezidingo zezigaba ezahlukene ukusuka ku-R&D kuya kwezezimboni.

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