I-LiragLutide Anti-Diabetics ye-Blood Sugar Control Cas No.204656-20-2

Incazelo emfushane:

Isithako esisebenzayo:I-LiragLutide (Analog ye-purtide yabantu - 1 (GLP-1) ekhiqizwa imvubelo ngobuchwepheshe bezakhiwo zofuzo).

Igama lamakhemikhali:I-Argal34lys26- (N-ε-Glu (N-α-hexadecanoyl)) - I-GLP-1 [7-37]

Ezinye izithako:I-Dirodium hydrogen phosphate dihydrate, i-propylene glycol, i-hydrochloric acid kanye / noma i-sodium hydroxide (njengezinguquko ze-ph kuphela), i-phenol kanye namanzi omjovo.

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Imininingwane Yomkhiqizo

Umkhoga	204656-20-2	Ifomula yamangqamuzana	C₁₇₂H₂₆₅N₄₃O₅₁
Isisindo molecular	3751.20	Ukubonakala	Okumhlophe
Isimo sokugcina	Ukumelana nokukhanya, 2-8 degree	Isishuqulu	I-Aluminium Foil Bag / Vial
Ubumsulwa	≥98%	Ukuthutha	Iketanga elibandayo nokulethwa okupholile kokugcina

Izithako zeLiraglutide

Isithako esisebenzayo:

I-LiragLutide (Analog ye-purtide yabantu - 1 (GLP-1) ekhiqizwa imvubelo ngobuchwepheshe bezakhiwo zofuzo).

Igama lamakhemikhali:

I-Argal34lys26- (N-ε-Glu (N-α-hexadecanoyl)) - I-GLP-1 [7-37]

Ezinye izithako:

I-Dirodium hydrogen phosphate dihydrate, i-propylene glycol, i-hydrochloric acid kanye / noma i-sodium hydroxide (njengezinguquko ze-ph kuphela), i-phenol kanye namanzi omjovo.

Isicelo

Uhlobo 2 Isifo Sikashukela

ILiraglutide ithuthukisa ukulawulwa kwe-glucose yegazi. Inciphisa i-hyperglycemia ehlobene nokudla (amahora angama-24 ngemuva kokuphathwa kwe-insulin (kuphela) lapho kudingwa ukwandisa amazinga we-glucose, kubambezele ukuthulula i-glucagon secreion.
Ilungele iziguli ezinoshukela wegazi elinamasu asalawulwa kahle ngemuva komthamo omkhulu wokubekezelela we-metformin noma sulfonylures kuphela. Isetshenziswa ngokuhlanganiswa ne-metformin noma sulfonylureas.
Isebenza ngendlela ethembele kashukela, okusho ukuthi izovusa imfihlo ye-insulin kuphela lapho amazinga kashukela egazi aphezulu kunokwejwayelekile, ukuvimbela "ukweqa". Ngenxa yalokho, kukhombisa ubungozi obungathandeki be-hypoglycemia.
Inamandla okuvimbela i-apoptosis kanye nokuvuselelwa kabusha kokuvuselelwa kabusha kwamaseli we-beta (abonwa ezifundweni zezilwane).
Kwehlisa isifiso sokudla futhi kuvimbela ukuzuza kwesisindo somzimba, njengoba kukhonjisiwe ekufundeni ikhanda ukuya ekhanda kuqhathaniswa ne-glimethiride.

Isenzo samakhemisi

I-LiragLutide iyi-analog ye-GLP-1 ene-97% yokulandelana i-Homology ku-Human GLP-1, engabopha futhi isebenze i-gep-1 receptor. I-GLP-1 Receptor yilitshe lendabuko le-GLP-1, i-hormone ye-Endogenous Ancretin ekhuthaza ukufakwa kwe-insulin ukugxila kwe-glucose kusuka kumaseli we-pancreatic β. Ngokungafani neNative GLP-1, amaphrofayili we-pharmacokinetic kanye nama-pharmacodynamic we-liraglutide kubantu alungele irejimeni elakhiwe nsuku zonke. Ngemuva komjovo ongaphansi, indlela yalo yesenzo eside ihlanganisa: ukuzijabulisa okukuthambisa ukumunwa; ukubopha i-albumin; Ukuqina okuphezulu kwe-enzyme ngakho-ke impilo ende ye-plasma.

Umsebenzi weLiraglutide udilizwa ngokuxhumana kwawo okuthize nge-glp-1 receptor, okuholela ekwandeni kwe-cyclic adenosine monophosphate (ikamu). I-LiragLutide ivusa imfihlo ye-insulin ngendlela encike kakhulu kashukela, ngenkathi inciphisa imfihlo ye-glucagon ngendlela encike kakhulu ye-glucose.

Ngakho-ke, lapho kuphakama uGlucose wegazi, kuvuselelwa ama-secreen we-insulin, kuyilapho imfihlo ye-glucagon ivinjelwa. Ngokuphambene, iLiraglutide inciphisa imfihlo ye-insulin ngesikhathi se-hypoglycemia ngaphandle kokuthinta imfihlo ye-glucagon. Indlela ye-hypoglycemic yeLiraglutide futhi ifaka ukunwebeka okuncane kokukhipha isikhathi esisheshayo. I-LiragLutide inciphisa isisindo somzimba kanye ne-mist fat mass ngokunciphisa indlala kanye nokudla kwamandla.

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