I-Leuprorelin Acetate ilawulwa ukucaciswa kwama-hormone e-gonadal

I-Leuprololide, uGoserelin, i-Tripelin, ne-NAFARELIN yizidakamizwa eziningana ezisetshenziswa kakhulu emtholampilo ukuze zisuse ama-ovari azokwelashwa komdlavuza webele we-premopausal kanye nomdlavuza we-prostate. (Kubhekwe njenge-GNRH-A DREDS), i-GNRH-ADDICS iyafana ngesakhiwo ku-GNRH futhi iqhudelane ne-Pituitary GNRH Receptors. Lokho wukuthi, i-gonadotropin etholwe yi-pituitary incipha, okuholela ekwehleni okukhulu ku-hormone yocansi etholwe yi-ovary.

I-Leuprolondide iyi-anadog ye-gonadotropin-ekhulula i-analog (i-GNRH), i-peptide eyakhiwa ama-amino acid ayi-9. Lo mkhiqizo ungavimbela ngempumelelo umsebenzi wohlelo lwe-Pituitary-Gonadal, ukumelana nama-enzyme ama-proteolytic kanye nobungqabavu ePituitary GNRH Receptor kunamandla kune-GNRH, kanye nomsebenzi wokukhuthaza ukukhishwa kwe-hormone (LH) okuvumayo okungama-20. Futhi inomphumela onamandla okuvimbela ku-Putaitary-Gonad umsebenzi kune-GNRH. Esigabeni sokuqala sokwelashwa, i-hollicle evuselelayo ye-hormone (FSH), i-lh, i-estrogen noma i-androgen ingakhuphuka okwesikhashana, bese kubangelwa ukuncishiswa kwe-pituitary, imfihlo ye-Fsh, i-lh kanye ne-estrogen noma i-arrogen kuvinjelwe ama-hormone wobulili. Izifo zocansi (njengomdlavuza we-Prostate, endometriosis, njll.) Yiba nomphumela wezokwelapha.

Njengamanje, usawoti we-acetate we-leuprololide usetshenziswa ikakhulukazi emtholampilo, ngoba ukusebenza kwe-leuprolide acetate kuzinze kakhulu ekushiseni kwegumbi. Uketshezi kufanele ulahlwe. Ingasetshenziselwa ukwelashwa kwezidakamizwa kwe-endometriosis kanye ne-uterine fibroids, umdlavuza webele oqinile, umdlavuza webele we-premopausal, futhi futhi nokopha kwesibeletho okusebenzayo okungekho emthethweni noma kungasebenzi kahle ekwelashweni kwama-hormone okujwayelekile. Ingasetshenziswa futhi njengokwakheka ngaphambi kokuvuselelwa kwe-endometrial, okunganciphisa ngokulinganayo i-endometrium, ukunciphisa i-edema, futhi kunciphise ubunzima bokuhlinzwa.