I-GnRH Antagonist Isetshenziselwa I-Peptides Synthesis
Imininingwane Yomkhiqizo
| NO | Imikhiqizo | Inombolo ye-CAS. | Isicelo | Inkomba Yekhwalithi Ebalulekile | ||||
| Ubumsulwa | Isomer | Ukungcola okuqondile | *Ubukhulu 1 | Umswakama | ||||
| 1 | I-Fmoc-3-(2-naphthyl)-D-Ala-OH | 138774-94-4 | Imikhiqizo eminingi | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 2 | I-Ac-3-(2-naphthyl)-D-Ala-OH | 37440-01-0 | Imikhiqizo eminingi | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 3 | I-Fmoc-3-(3-pyridinyl)-D-Ala-OH | 142994-45-4 | Imikhiqizo eminingi | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 4 | I-Fmoc-4-chloro-D-Phe-OH | 142994-19-2 | Imikhiqizo eminingi | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 5 | Fmoc-D-Cit-OH | 200344-33-8 | I-Cetrorelix | ≥99.5% | ≤0.1% | ≤0.1% | ≤0.2% | ≤1.0% |
| 6 | I-Fmoc-D-Ala-OH.H2O | 79990-15-1 | Imikhiqizo eminingi | ≥99.5% | ≤0.1% | ≤0.1% | ≤0.2% | ≤6.5% |
| 7 | I-Fmoc-D-Aph(tBuCbm)-OH | 1433975-21-3 | Degarelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 8 | I-Fmoc-D-Aph(Cbm)-OH | 324017-22-3 | Degarelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 9 | I-Fmoc-L-Aph(L-Hor)-OH | 1253282-31-3 | Degarelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 10 | I-Fmoc-L-Ls(iPr,Boc)-OH | 201003-48-7 | Degarelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 11 | I-Fmoc-N-Me-Tyr(tBu)-OH | 133373-24-7 | Abarelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 12 | I-Fmoc-D-Asn(Trt)-OH | 180570-71-2 | Abarelix | ≥99.0% | ≤0.2% | ≤0.3% | ≤0.3% | ≤1.0% |
| 13 | I-Fmoc-HomoArg(Et)2-OH.HCl | 1864003-26-8 | I-Ganirelix | ≥95.0% | ≤0.5% | ≤1.0% | ≤2.0% | ≤2.0% |
| 14 | I-Fmoc-D-HomoArg(Et)2-OH.HCl | 2098497-24-4 | I-Ganirelix | ≥95.0% | ≤0.5% | ≤1.0% | ≤2.0% | ≤2.0% |
| 15 | I-Fmoc-Ls(nicotinoyl)-OH | 252049-11-9 | I-Antide | ≥98.0% | ≤0.2% | ≤0.3% | ≤0.5% | ≤1.0% |
| 16 | I-Fmoc-D-Lys(nicotinoyl)-OH | 252049-12-0 | I-Antide | ≥98.0% | ≤0.2% | ≤0.3% | ≤0.5% | ≤1.0% |
* I-Max1 = Ukungcola Okungaziwa Okuphezulu
Esinye isikhombi:
I-Acetic Acid: ≤0.02% (Yonke Imikhiqizo)
I-Ethyl Acetate: ≤0.5% (Yonke Imikhiqizo)
- Utshwala: ≤0.5% (Yonke Imikhiqizo)
I-TOC kanye ne-Conductivity
I-TOC kanye ne-conductivity ye-main supply kanye nezindawo zokubuyisela zibhekwa ngezikhathi ezithile.I-TOC igadwa yi-QC masonto onke.I-Conductivity igadwa nge-inthanethi futhi irekhodwa ngumqhubi wesiteshi samanzi ahlanzekile kanye njalo emahoreni amane.I-conductivity igadwa ku-RO eyinhloko, i-RO yesibili, i-EDI kanye nendawo yokubuya ephelele yohlelo lokusabalalisa.Ukucaciswa kwamanzi ahlanzekile kusendaweni futhi kuvumelana nezicaciso ezichazwe ngaphambilini ezingekho ngaphezu kuka-1.3 µs/cm ku-25°C (USP).Ngokunikezwa okuyinhloko namaphoyinti okubuyisela, ukuhlolwa okugcwele.Kwenziwa masonto onke, kwezinye izindawo zokusebenzisa ku-loop ejikelezayo, ukuhlolwa okugcwele kwenziwa kanye ngenyanga.Ukuhlolwa okuphelele kufaka phakathi izinhlamvu, i-pH, i-nitrate, i-nitrite, i-ammonia, i-conductivity, i-TOC, izinto ezingaguquki, izinsimbi ezisindayo, imikhawulo ye-microbial kanye ne-endotoxin yebhaktheriya.
