I-Tirzepatide

I-Tirzepatide API
I-Tirzepatide iyi-peptide yokwenziwa ephuhlayo esebenza njenge-agonist ekabili yakho kokubili i-insulinotropic polypeptide (GIP) encike ku-glucose kanye ne-glucagon-like peptide-1 (GLP-1) receptors. Imele isigaba esisha semithi yokwelapha esekwe ku-incretin eyaziwa ngokuthi “ama-twincretins”, enikeza ukulawulwa okuthuthukisiwe kwe-metabolic ezigulini ezinesifo sikashukela sohlobo 2 kanye nokukhuluphala.

I-Tirzepatide API yethu ikhiqizwa ngamasu athuthukile okuhlanganiswa kwamakhemikhali, iqinisekisa ubumsulwa obuphezulu, amazinga aphansi wokungcola, kanye nokuvumelana okuhle kakhulu kwe-batch-to-batch. Ngokungafani nama-peptide atholakala ku-rDNA, i-API yethu yokwenziwa ayinamaphrotheni eseli abambayo kanye ne-DNA, ithuthukisa kakhulu i-biosafety kanye nokuhambisana nokulawula. Inqubo yokukhiqiza ithuthukisiwe ukuze ikhule ukuze ihlangabezane nesidingo esikhulayo somhlaba.

Indlela Yokwenza
I-Tirzepatide isebenza ngokuvuselela ngasikhathi sinye kokubili i-GIP kanye ne-GLP-1 receptors, inikeze imiphumela ehambisanayo ne-synergistic:

Ukusebenza kwe-GIP receptor: kuthuthukisa ukugcinwa kwe-insulin futhi kungase kuthuthukise ukuzwela kwe-insulin.

Ukwenziwa kusebenze kwe-GLP-1 receptor: cindezela ukukhululwa kweglucagon, ukubambezela ukuphuma kwesisu, futhi kunciphisa isifiso sokudla.

Umsebenzi ohlanganisiwe uholela ku:

Ukulawulwa kwe-glycemic okuthuthukisiwe

Ukuncipha kwesisindo somzimba

Ukusutha okuthuthukisiwe kanye nokudla okuncishisiwe

Ucwaningo Lwezempilo Nemiphumela
I-Tirzepatide ibonise ukusebenza ngendlela engakaze ibonwe ezivivinyweni eziningi zomtholampilo ezinkulu (SURPASS & SURMOUNT series):

Ukwehliswa okuphezulu kwe-HbA1c uma kuqhathaniswa nama-GLP-1 RAs (isb, i-Semaglutide)

Ukuncipha kwesisindo kufika ku-22.5% ezigulini ezikhuluphele - okuqhathaniswa nokuhlinzwa kwe-bariatric kwezinye izimo

Ukuqala komphumela osheshayo kanye nokulawulwa okuqinile kwe-glycemic phezu kokusetshenziswa kwesikhathi eside

Izimpawu ezithuthukisiwe ze-cardiometabolic: kufaka phakathi umfutho wegazi, i-lipids, nokuvuvukala

I-Tirzepatide ayishintshi nje kuphela ipharadigm yokwelapha yohlobo 2 lwesifo sikashukela kodwa futhi ivela njengendlela yokwelapha enkulu yokuncipha kwesisindo sezokwelapha kanye nesifo se-metabolic.

Ikhwalithi & Ukuhambisana
I-Tirzepatide API yethu:

Ihlangabezana nezindinganiso zekhwalithi zomhlaba (i-FDA, ICH, EU)

Ihlolwe nge-HPLC ukuthola amazinga aphansi okungcola okwaziwayo nokungaziwa

Kwenziwe ngaphansi kwezimo ze-GMP ngemibhalo yenqubo egcwele

Sekela ukukhiqizwa kwe-R&D ngezinga elikhulu