I-Tireptine sodium yeziqephu ezicindezelayo

Umsebenzi

Isebenza ikakhulukazi ohlelweni lwe-5-HT, ngaphandle kwenjabulo, i-sedation, anti-acetylcholine kanye ne-cardioticity. Ngokudangala.

Umphumela wekhemisi

1. Indlela yokudla okune-antidepressant yalo mkhiqizo yehlukile kwaleyo ye-TCA yendabuko. Kungakhuphula ukuthandwa kwe-5-HT ku-synaptic Cleft, kepha kunomthelela obuthakathaka ekuphindaphindweni kwe-5-HT ne-NA. Ingaba nomphumela wokuthuthukisa ukuhanjiswa kwe-neuronal okungu-5-HT. Akunakuqhathaniswa nama-receptors, H1, α1 kanye í2-na receptors.
2. Ukusebenza kwe-antideressured kwalo mkhiqizo kuyafana nalokho kwe-TCA, futhi ukuphepha kwayo nokubekezelelana kungcono kune-TCA (TricyClic AntidePsressions). Ukusebenza kahle kwalo mkhiqizo kuyafana nalokho kwe-SSRI Fluoxetine.
3 Khulisa ukubuyiselwa kwe-5-hydroxyrytamine ngama-neurons ku-cerebral cortex kanye ne-hippocampus.

Izifundo Zobuthi

- Ukuhlolwa kobuthi be-acute, ukuzithoba kanye nobuthi be-Ubuthi be-Ubuthi: Akukho zinguquko ku-biology, umsebenzi wesibindi, i-anatomy ye-pathological.
- Ubuthi bokuzala kanye nokuhlolwa kweTeratogenicity: I-Tianeptine ayinamthelela emandleni okuzala kwabazali abaphathiswe kanye nasezinkuzane.
- Ukuhlolwa kwe-Mutagenicity: I-Tianeptine ayinawo umphumela we-mutagenic.