... I-China Chondroitin Sulfate Yokwelapha Isifo Senhliziyo, I-Arthritis kanye Nokuphulukiswa Kwamanxeba E-Corneal Purity 98% ifektri nabakhiqizi |Gentolex
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I-Chondroitin Sulfate yokwelashwa kwe-Coronary Heart Disease, i-Arthritis kanye nokuphulukiswa kwamanxeba angama-Corneal Purity 98% Isithombe Esifakiwe
  • I-Chondroitin Sulfate yokwelashwa kwe-Coronary Heart Disease, i-Arthritis kanye nokuphulukiswa kwe-Corneal Wounds Purity 98%
  • I-Chondroitin Sulfate yokwelashwa kwe-Coronary Heart Disease, i-Arthritis kanye nokuphulukiswa kwe-Corneal Wounds Purity 98%

I-Chondroitin Sulfate yokwelashwa kwe-Coronary Heart Disease, i-Arthritis kanye nokuphulukiswa kwe-Corneal Wounds Purity 98%

Incazelo emfushane:

Inombolo ye-CAS: 9007-28-7

Ifomula yemolekyuli: C13H21NO15S

Isisindo se-molecule: 463.36854

Inombolo ye-EINECS: 232-696-9

Ifomu: powder

Umbala: Okumhlophe ukuya kokumhlophe

Ukunyibilika kwamanzi: Kuncibilika emanzini

Ubumsulwa: 98%


Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Imininingwane Yomkhiqizo

Igama I-Chondroitin sulfate
Inombolo ye-CAS 9007-28-7
Ifomula yamangqamuzana I-C13H21NO15S
Isisindo samangqamuzana 463.36854
Inombolo ye-EINECS 232-696-9
Ukuncibilika kwamanzi Incibilika emanzini
Ubumsulwa 98%
Isitoreji Gcina ekushiseni okuvamile
Ifomu Impushana
Umbala Okumhlophe kuya kokumhlophe
Ukupakisha Isikhwama se-PE+Isikhwama se-Aluminium

Omqondofana

i-poly-1 (2/3)-n-acetyl-2-amino-2-deoxy-3-o-beta-d-glucopyranurosyl-4-(6)sulfonyl-d-galactose;i-chondroitinpoly sulfate;i-chondroitin sulfates;i-chondroiti sulfuricacid;i-chondroitin sulfuric acid;i-chonsurid;CSO;(5ξ) -2-(Carboxyamino)-2-deoxy-3-O-β-D-glucopyranuronosyl-4-O-sulfo-α-L-arabino-hexopyranose

I-Pharmacological Effect

Incazelo

I-Chondroitisulfate (CS) i-mucopolysaccharide ene-asidi ekhishwe futhi yahlanzwa ku-cartilage yezilwane.I-Chondroitin sulfate inezinhlaka ezahlukene ezifana no-A, C, D, E, H no-K. I-Chondroitin sulfate ngokwemvelo itholakala kakhulu kuqwanga lwezilwane, ithambo lomphimbo, ithambo lekhala (41% ezingulubeni), izinkomo, i-horse septum kanye noqhoqhoqho (oqukethe I-36% kuya ku-39%), ezinye izicubu ezifana namathambo omlenze, imigqa, isikhumba, i-cornea, njll.Okuqukethwe kwe-fish cartilage kucebile kakhulu, njenge-50% kuya ku-60% ethanjeni likashaka, futhi kuncane kakhulu kuzicubu ezixhumeneyo.

Ngesifo se-coronary atherosclerotic, ukwanda kwe-lipids yegazi kanye ne-cholesterol, i-arteriosclerosis, i-angina pectoris, i-myocardial ischemia, i-myocardial infarction, njll ezigulini ezinesifo senhliziyo.

 

Isenzo se-Pharmacological

I-Rapamycin (RAPA) inemiphumela emibi efanayo ne-FK506.Ezinhlolweni eziningi zomtholampilo, imiphumela yayo engemihle itholwe incike kumthamo futhi ihlehliswa, futhi i-RAPA kumithamo yokwelapha ayizange itholakale ine-nephrotoxicity ebalulekile futhi ayikho i-gingival hyperplasia.I-toxic and side effects main ihlanganisa: ikhanda, isicanucanu, isiyezi, ukopha, nobuhlungu bamalunga.Izinkinga zaselabhorethri zihlanganisa: i-thrombocytopenia, i-leukopenia, i-hemoglobin ephansi, i-hypertriglyceridemia, i-hypercholesterolemia, i-hyperglycemia, i-enzyme ephakeme yesibindi (i-SGOT, i-SGPT), i-lactate dehydrogenase ephakeme, i-hypokalemia, i-Hypomagnesemia, njll. Amazinga e-plasma phosphate kucatshangwa ukuthi ukukhishwa kwe-phosphate ende kusuka ezinso ezitshalwe kabusha ngokwelashwa kwe-immunosuppressive okusekelwe ku-RAPA.Njengamanye ama-immunosuppressive, i-RAPA inethuba elikhulayo lokutheleleka, ngokuthambekela okubikiwe kokwandisa inyumoniya ikakhulukazi, kodwa ukwenzeka kwezinye izifo ezingosomathuba akuhlukile kakhulu ku-CsA.

 

I-Toxicological Effects

I-Chondroitin sulfate ikhona kakhulu ku-cartilage yabantu nezilwane.Ukulungiswa komuthi ikakhulukazi kuqukethe ama-isomers amabili we-chondroitin sulfate A ne-chondroitin sulfate C, futhi okuqukethwe kwe-chondroitin sulfate ku-cartilage yezilwane zezinhlobo ezahlukene neminyaka kuhlukile.Imiphumela yayo ye-pharmacological kanje: i-chondroitin sulfate ingasusa i-lipids nama-lipoprotein egazini, isuse i-cholesterol emithanjeni yegazi ezungeze inhliziyo, ivimbele futhi iphathe i-atherosclerosis, futhi yandise izinga lokuguqulwa kwe-lipids namafutha acids kumaseli.I-Chondroitin sulfate ingavimbela ngempumelelo futhi iphathe isifo senhliziyo.Ine-anti-atherosclerosis kanye nemiphumela yokwakheka kwama-atherogenic plaque kumamodeli wokuhlola we-arteriosclerosis;kwandisa amagatsha e-coronary noma umjikelezo wokujikeleza kwe-atherosclerosis, futhi kungasheshisa ukuhlolwa kwe-coronary arteriosclerosis noma i-embolism.Ukuphulukiswa, ukuvuselelwa nokulungiswa kwe-myocardial necrosis noma ukuwohloka.Ingakhuphula i-biosynthesis ye-cell messenger ribonucleic acid (mRNA) kanye ne-deoxyribonucleic acid (DNA) futhi ibe nomthelela wokuthuthukisa i-cell metabolism.Umsebenzi ophansi we-anticoagulant.I-Chondroitin sulfate inomphumela we-anticoagulant olinganiselayo, futhi i-1 mg ngayinye ye-chondroitin sulfate A ilingana nomsebenzi we-anticoagulant we-0.45U we-heparin.Lo msebenzi we-anticoagulant awuncikile ku-antithrombin III ukuze udlale indima yawo, ungenza umsebenzi we-anticoagulant ngokusebenzisa uhlelo lwe-fibrinogen.I-Chondroitin sulfate nayo ine-anti-inflammatory, ukusheshisa ukuphulukiswa kwesilonda kanye nemiphumela yokulwa ne-tumor.

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