I-Sildenafil Citrate Ukwelapha I-Erectile Dysfunction 171599-83-0
Imininingwane Yomkhiqizo
| Igama | I-Sildenafil Citrate |
| Inombolo ye-CAS | 171599-83-0 |
| Ifomula yamangqamuzana | I-C28H38N6O11S |
| Isisindo samangqamuzana | 666.70 |
| Inombolo ye-EINECS | 200-659-6 |
| I-Merck | 14,8489 |
| Ukuminyana | 1.445g/cm3 |
| Isimo sesitoreji | 2-8°C |
| Ifomu | Impushana |
| Umbala | Emhlophe |
| Ukuncibilika kwamanzi | I-DMSO: >20mg/mL |
Omqondofana
I-Viagra, i-Sildenafil citrate; 1- [[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazinecitratesalt; 5--[2-Ethoxy-5-(4-methylpiperazin-1-yl) sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-onecitratesalt; 1--[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; I-SildenafilCitrate(100mg); Sildenafilcitrate,>=99%;Sildenafilcitrate,Professionalsupply; 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-onecitrate
I-Pharmacological Effect
Isenzo se-Pharmacological
I-Sildenafil citrate iyi-inhibitor ekhethiwe ye-5-phosphodiesterase ethuthukisa i-nitric oxide-dependent, i-cyclic guanosine monophosphate-mediated pulmonary vasodilation ngokuvimbela ukuwohloka kwe-cyclic guanosine monophosphate. Ngaphezu kokwandiswa okuqondile kwemithambo yegazi yamaphaphu, kungaphinde kuvimbele noma kuguqule ukuguqulwa kwemithambo yegazi.
Izakhiwo Zokwelapha kanye Nezicelo
I-Sildenafil citrate, igama lokuhweba i-Viagre, evame ukubizwa ngokuthi i-Viagra, i-cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) inhibitor engathuthukisa ukumiswa ngemva kokuphathwa komlomo. I-Sildenafil citrate ingathuthukisa umphumela we-nitric oxide (NO) ngokuvimbela uhlobo lwe-5 phosphodiesterase olubola i-cyclic guanosine monophosphate (cGMP) ku-corpus cavernosum. Khulisa izinga le-cGMP ku-corpus cavernosum, phumuza umsipha obushelelezi ku-corpus cavernosum, ukhuphule ukungena kwegazi, unwebe isikhathi sokumiswa komthondo futhi ukwandise ukuqina. Okweziguli ezingenamandla okungasebenzi kahle kwe-erectile. Abantu abadala bathatha i-50 mg ngomlomo isikhathi ngasinye, kuze kufike ku-1 isikhathi ngosuku, futhi bayisebenzise njengoba kudingeka cishe ihora elingu-1 ngaphambi kokuya ocansini. Inani eliphakeme kakhulu ngu-0.1g isikhathi ngasinye.
Izifundo ze-vivo
Ezinjeni ezine-anesthetized, i-Sildenafil citrate ithuthukisa umsebenzi we-penile erectile ngaphansi kwe-pelvic nerve stimulation ngokulinganisa ingcindezi ye-intracavernous. I-Sildenafil citrate iguqule ngokuphawulekayo ukuphumula okuphazamisekile kwe-carbamoylcholine kanye nokwakheka kwe-superoxide esikhumbeni se-cavernosal onogwaja be-hypercholesterolemic. Emagundaneni e-Sprague-Dawley, i-Sildenafil ithuthukisa umsebenzi we-erectile ngendlela encike kumthamo wesikhathi, ngokululama okukhulu okwenzeka ngosuku lwe-28 ngesilinganiso se-20 mg / kg ngosuku. Emagundaneni e-Sprague-Dawley, ukuphathwa kwe-Sildenafil kubangele ukulondolozwa kwesilinganiso se-muscle collagen ebushelelezi kanye nokulondolozwa kwe-CD31 ne-eNOS expression. Emagundaneni e-Sprague-Dawley, i-Sildenafil yehlisa kakhulu inkomba ye-apoptotic futhi yandisa i-phosphorylation ye-akt ne-eNOS uma kuqhathaniswa neqembu lokulawula.
