I-RU-58841 Isetshenziswa Njengokuvimbela Ukulahlekelwa Izinwele kanye Nempandla Yephethini Yabesilisa
Imininingwane Yomkhiqizo
| Igama | RU-58841 |
| Inombolo ye-CAS | 154992-24-2 |
| Ifomula yamangqamuzana | I-C17H18F3N3O3 |
| Isisindo samangqamuzana | 369.34 |
| Inombolo ye-EINECS | 1592732-453-0 |
| Iphuzu elibilayo | 493.6±55.0 °C(Kubikezelwe) |
| Ukuminyana | 1.39 |
| Isimo sesitoreji | Ivalwe endaweni eyomile, Gcina efrijini, ngaphansi kuka -20°C |
| Ifomu | Impushana |
| Umbala | Emhlophe |
| Ukupakisha | Isikhwama se-PE+Isikhwama se-Aluminium |
Omqondofana
RU58841;4-(4,4-Dimethyl-2,5-dioxo-3-(4-hydroxybutyl)1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile;4--[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl-fluomethyl-fluomethyl i-onitrile;4--[3-(4-Hydroxybutyl)-4,4-diMethyl-2,5-dioxoiMidazolidin-1-yl]-2-(trifluoroMethyl) ben zonitrile;RU-58841E:candyli(at)speedgainpharma(dot)com;CS-637;RU588841;RU58841;RU58841;RU-58841
I-Pharmacological Effect
Incazelo
I-RU 58841 (PSK-3841) iphikisana ne-androgen receptor ekhuthaza ukukhula kabusha kwezinwele.I-RU58841 isidakamizwa esiphenywayo esidalelwe ukwelashwa ngokumelene ne-androgenic alopecia, eyaziwa nangokuthi i-male pattern baldness(MPD).
Njenge-anti-androgen ye-topical, isimiso sayo sesenzo asifani nese-finasteride. I-Finasteride isebenza ngokuqondile ku-5α reductase, ivimbela ukuguqulwa kwe-testosterone ku-DHT, futhi inciphisa okuqukethwe kwe-DHT emzimbeni. I-RU58841 ivimba ukuthintana phakathi kwe-dihydrotestosterone kanye ne-follicle receptors yezinwele, ayinciphisi ngokuqondile okuqukethwe kwe-DHT, kodwa inciphisa ukubopha kwe-DHT ne-follicle receptors yezinwele, ukuze kufezeke injongo yokwelapha i-alopecia ye-androgenetic.
I-4--[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl] -2-(trifluoromethyl)benzonitrile ingasetshenziswa njengomuthi I-Chemical synthesis intermediates.Uma i-4--[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl] -2-(trifluoromethyl)benzonitrile ihogelwa, Hambisa isiguli emoyeni omusha;Uma kwenzeka uthinta isikhumba, susa izingubo ezingcolile, hlambulula isikhumba kahle ngensipho namanzi, futhi ufune usizo lwezokwelapha uma kwenzeka ukungakhululeki;
I-Side Effect
I-RU58841 isetshenziswa esikhumbeni, idonswa yizinwele zezinwele, futhi ngokwengqondo, ingangena egazini futhi ithinte ezinye izingxenye zomzimba. Kodwa ayikho imiphumela emibi yesistimu etholakele ocwaningweni lokusetshenziswa kwezihloko ezinkawini. Kodwa-ke, abanye abantu abaye bazama i-RU58841 bathi baye babhekana nemiphumela engemihle engenzeka ngokusebenzisa i-RU, okuhlanganisa ukucasuka kwesikhumba, ukuncipha kwe-libido, ukungasebenzi kahle kwe-erectile, isicanucanu, amehlo abomvu, isiyezi, kanye nekhanda elibuhlungu.
