URapamycin uyisidakamizwa esiku-immunosuppresprespresprespresprespressive, umdlavuza kanye nokulwa nokulwa nokuguga

Ukufanisa

I-Rapamycin iyi-macrolide antibiotic efanekisa nge-ProCrofol (FK506), kepha inenqubo ehluke kakhulu ye-immunosuppresssm. I-FK506 ivimbela ukwanda kwama-t lymphocyte kusuka esigabeni se-G0 ukuya esigabeni se-G1, ngenkathi ama-rapA ama-rap avela ku-FK506, i-rapA angavimba izindlela zokuncika kwe-G1 ezivela ku-CYMSTIENT ne-Calcium Abaphenyi bezokwelapha base-University of Chicago basebenzisa amathebhulethi atholakala kweRapamycin atholakalayo kanye ne-grapefruit juice ukwelapha i-melanoma, isimo esivamile se-calapefrant eYurophu nase-United States, ngaleyo ndlela sikwazi ukubhekana nokusinda kweziguli isikhathi. Ucwaningo luye lwabonisa ukuthi iRapamycin ibolekwa kalula ngama-enzyme ngemuva kokufaka ipheshana yokugaya, futhi ujusi wamagilebhisi aqukethe inani elikhulu lama-furanocoumarins, angavimba umphumela owonakalisayo wokugaya ama-enzyme ahamba nge-rabamycin. Ingathuthukisa i-bioavailability yeRapamycin. Kuthiwa odokotela base-DURCHSTIO BESIFAZANE bathole ukuthi ijusi lamagilebhisi linomphumela wokwenza ngcono ukumuncwa ngomlomo kwama-Shaning, futhi manje odokotela emazweni aseYurophu naseMelika bakusebenzise kumalungiselelo eRapamycin.

Eminyakeni yamuva nje, ucwaningo luthole ukuthi ilitshe leRapamycin (MTOR) liyi-kinase ye-intramycin, futhi ukuhlukunyezwa kwendlela yalo ye-conduction kungaheha izifo ezahlukahlukene. Njenge-invibitor ebhekisiwe ye-MTOR, iRapamycin ingaphatha amathumbu ahlobene kakhulu nale ndlela, kufaka phakathi umdlavuza we-renal, i-lymphoma, umdlavuza wamaphaphu, umdlavuza wesibindi, umdlavuza webele, umdlavuza webele kanye nomdlavuza we-neurontric. Ikakhulu ekwelapheni izifo ezimbili ezingandile, i-lam (lymphangiomyosis) ne-TSC (i-tuberous sclerosis), umphumela usobala, futhi i-lam ne-TSC nayo ingabhekwa njengezifo zemitina ngezinga elithile.

Umphumela wecala

I-Rapamycin (RapA) inemiphumela emibi efanayo ku-FK506. Esikhathini esikhulu sezilingo zomtholampilo, imiphumela yayo emibi yatholakala ukuthi ithembeke umthamo futhi iguqulwe, futhi i-rapA ngemithamo yokwelapha ayitholakalanga ukuthi ine-nephrotoxicia ebalulekile futhi akukho gingival hyperplasia. Imiphumela enobuthi enobuthi kanye nemibi ifaka: ikhanda, isicanucanu, isiyezi, ama-nosebleed, nobuhlungu obuhlangene. Ukuhlukunyezwa kwelebhu kufaka phakathi: I-Thrombopenia, i-hemoglobin ephansi, i-hypercriglytolemia, i-hyperglytemia, i-hyperglycemia, i-hypomagtemia, stymema, stymema muva nje kubikwa ngeRapa Ukuphatha, kanye nembangela yamazinga aphansi we-plasma phosphate kucatshangwa ukuthi kudluliswa isikhathi eside phosphate kusuka ezinsolweni ezitshaliwe yi-rapa-based immunosuppy therapy. Njengamanye ama-Immunosuppressants, iRapa inethuba elikhulayo lokutheleleka, ngokuthambekela okubikiwe ukwandisa inyumoniya ikakhulukazi, kodwa ukwenzeka kwezinye izifo ezinamathuba akwehlukile kakhulu ku-CSA.