I-Pegcetacoplan

I-Pegcetacoplan API

I-Pegcetacoplan iyipeptide ye-pegylated cyclic esebenza njenge-C3 complement inhibitor ehlosiwe, eyenzelwe ukwelashwa kwezifo ezihambisanayo ezifana ne-paroxysmal nocturnal hemoglobinuria (PNH) kanye ne-geographic atrophy (GA) ekuwohlokeni kwe-macular okuhlobene neminyaka.

Inqubo Nocwaningo:
I-Pegcetacoplan ibophezela ekugcwaliseni amaprotheni i-C3 ne-C3b, ivimbela ukusebenza kwe-cascade ehambisanayo. Lokhu kunciphisa:
I-Hemolysis nokuvuvukala ku-PNH
Ukulimala kweseli ye-retinal ku-geographic atrophy
Ukulimala kwezicubu ezixhumene namasosha omzimba kwezinye izifo eziqhutshwa umphelelisi