I-Palopegteriparatide

I-Palopegteriparatide API

I-Palopegteriparatide iyi-agonist esebenza isikhathi eside ye-parathyroid hormone receptor (PTH1R agonist), eyenzelwe ukwelashwa kwe-hypoparathyroidism engapheli. Kuyi-analog ye-pegylated ye-PTH (1-34) eklanyelwe ukunikeza ukulawulwa kwe-calcium okuqhubekayo ngokudosa kanye ngeviki.

Inqubo Nocwaningo:
I-Palopegteriparatide ibophezela kuma-PTH1 receptors, ibuyisela ibhalansi ye-calcium ne-phosphate ngokuthi:

• Ukwandisa i-serum calcium

• Ukunciphisa ukuphuma kwe-calcium kumchamo

• UkusekelaI-metabolism yamathambo kanye ne-homeostasis yamaminerali