I-Orlistat 96829-58-2 Yehlisa Ukumuncwa Kwamafutha E-Sietary, Okuholela Ekulahlekeni Kwesisindo

Izakhiwo

I-crystalline powder emhlophe, cishe ayincibiliki emanzini, incibilika kalula ku-chloroform, incibilika kakhulu ku-methanol ne-ethanol, i-pyrolyze kalula, indawo encibilikayo ingu-40℃～42℃. I-molecule yayo iyi-diastereomer equkethe izikhungo ezine ze-chiral, kubude begagasi obungu-529nm, isixazululo sayo se-ethanol sinokujikeleza kwe-optical negative.

Imodi Yesenzo

I-Orlistat iyi-inhibitor ye-lipase esebenza isikhathi eside futhi enamandla, eyenza ama-enzyme amabili angenhla angasebenzi ngokwakha isibopho esihlangene nendawo esebenzayo ye-serine ye-lipase esiswini namathumbu amancane. Ama-enzyme angasebenzi awakwazi ukudiliza amafutha ekudleni abe ama-fatty acids mahhala kanye ne-Chemicalbook glycerol engamuncwa umzimba, ngaleyo ndlela ehlise ukudla kwamafutha futhi ehlise isisindo. Ngaphezu kwalokho, olunye ucwaningo luthole ukuthi i-orlistat ivimbela ukumuncwa kwe-cholesterol emathunjini ngokuvimbela i-niemann-pick C1-like protein 1 (niemann-pickC1-like1, NPC1L1).

Izinkomba

Lo mkhiqizo ngokuhambisana nokudla okuphansi kwe-hypocaloric uboniswa ekwelapheni isikhathi eside kwabantu abakhuluphele nabakhuluphele ngokweqile, okuhlanganisa nalabo abanezici eziyingozi ezisunguliwe ezihlobene nokukhuluphala. Lo mkhiqizo unokulawula isisindo sesikhathi eside (ukulahlekelwa isisindo, ukugcinwa kwesisindo nokuvimbela ukuphindaphinda) ukusebenza kahle. Ukuthatha i-orlistat kunganciphisa izici eziyingozi ezihlobene nokukhuluphala kanye nezigameko zezinye izifo ezihlobene nokukhuluphala, okuhlanganisa i-hypercholesterolemia, uhlobo lwesifo sikashukela sohlobo 2, ukubekezelela i-glucose okuphazamisekile, i-hyperinsulinemia, umfutho wegazi ophakeme, nokuqukethwe kwamafutha okunciphisa izitho.

Ukusebenzisana Kwemithi

Inganciphisa ukumuncwa kwamavithamini A, D no-E. Inganezelwa ngalo mkhiqizo ngesikhathi esifanayo. Uma uthatha amalungiselelo aqukethe amavithamini A, D no-E (njengamanye ama-multivitamine), kufanele uthathe lo mkhiqizo amahora angu-2 ngemva kokuthatha lo mkhiqizo noma ngesikhathi sokulala. Abantu abanesifo sikashukela sohlobo 2 bangadinga ukunciphisa umthamo wama-ejenti omlomo we-hypoglycemic (isb, i-sulfonylureas). Ukuphatha ngokubambisana ne-cyclosporine kungaholela ekwehleni kokugxila kwe-plasma kokugcina. Ukusetshenziswa kanyekanye kwe-amiodarone kungaholela ekwehleni kokumuncwa kokugcina kanye nokuncipha kokusebenza kahle.