I-MOTS-C

Incazelo emfushane:

I-MOTS-C API ikhiqizwa ngaphansi kwezimo eziqinile ezifana ne-GMP kusetshenziswa ubuchwepheshe obuqinile besigaba se-peptide synthesis (SPPS) ukuze kuqinisekiswe izinga layo eliphezulu, ukuhlanzeka okuphezulu nokuzinza okuphezulu kocwaningo nokusetshenziswa kokwelapha.
Izici Zomkhiqizo:

Ubumsulwa ≥ 99% (kuqinisekiswe yi-HPLC ne-LC-MS),
I-endotoxin ephansi kanye nokuqukethwe kwe-solvent eyinsalela,
Ikhiqizwe ngokuhambisana ne-ICH Q7 kanye ne-GMP-like protocols,
Ingafinyelela ukukhiqizwa kwezinga elikhulu, kusukela kumaqoqwana e-R&D eleveli ye-milligram ukuya kwezinga legremu kanye neleveli yekhilogremu ukunikezwa kwezohwebo.

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

I-MOTS-C API

I-MOTS-C(I-Mitochondrial Open Reading Frame ye-12S rRNA Type-c) iyi-16-amino acidi-peptide etholakala ku-mitochondria (MDP)ifakwe ikhodi ye-mitochondrial genome. Ngokungafani nama-peptide endabuko anekhodi yenuzi, i-MOTS-c isuka endaweni ye-12S rRNA ye-mitochondrial DNA futhi idlala indima ebalulekileilawula i-metabolism yamaselula, impendulo yokucindezeleka, nokuzwela kwe-insulin.

Njengenoveli peptide yokwelapha,I-MOTS-c APIuthole intshisekelo ebalulekile emikhakheni yeukuphazamiseka kwe-metabolic, ukuguga, i-physiology yokuzivocavoca, kanye nemithi ye-mitochondrial. I-peptide okwamanje ingaphansi kophenyo olunzulu lwe-preclinical futhi ithathwa njengekhandidethi elithembisayoisizukulwane esilandelayo sokwelapha i-peptideiqondise impilo ye-metabolic nokuphila isikhathi eside.

Indlela Yokwenza

I-MOTS-c isebenzisa imiphumela yayoi-mitochondrial-nuclear cross-talk-umshini lapho i-mitochondria ixhumana ne-nucleus ukuze kugcinwe i-homeostasis yeselula. I-peptide ithuthwa isuka ku-mitochondria iye ku-nucleus ngenxa yengcindezi ye-metabolic, lapho isebenzaisilawuli se-metabolicngokuthonya ukuvezwa kofuzo.

Izindlela ezibalulekile zebhayoloji zihlanganisa:

Ukwenziwa kusebenze kwe-AMPK (AMP-activated protein kinase):I-MOTS-c ivuselela i-AMPK, inzwa yamandla emaphakathi, ekhuthazayoukumuncwa kwe-glucose, i-fatty acid oxidation, kanye ne-mitochondrial biogenesis.
Ukwandisa ukuzwela kwe-insulin:I-MOTS-c inyusa ukuphendula kwe-insulin emisipha nezicubu ze-adipose, iyathuthukai-glucose homeostasis.
Ukunciphisa ukucindezeleka kwe-oxidative nokuvuvukala:Ngokulinganisa ibhalansi ye-redox yeselula kanye nezindlela zokubonisa ukuvuvukala.
Ukulawulwa komsebenzi we-mitochondrial kanye ne-biogenesis:Isekela impilo ye-mitochondrial, ikakhulukazi ngaphansi kwengcindezi noma izimo zokuguga.

Ucwaningo Lwezokwelapha kanye Nemiphumela Yebhayoloji

Ucwaningo lwe-preclinical lubonise imiphumela eminingi ye-physiological and therapeutic ye-MOTS-c kuzo zombili izinhlobo ze-in vitro nezilwane:

1. Izifo zeMetabolic (Ukukhuluphala, Uhlobo 2 sikashukela, Ukumelana ne-insulin)

Ithuthukisa ukubekezelelwa kwe-glucose futhi yehlise amazinga eglucose egazini
Iyathuthukisaukuzwela kwe-insulinngaphandle kokwenyusa amazinga e-insulin
Iyakhuthazaukwehla kwesisindo kanye ne-oxidation yamafuthakumagundane akhuluphele ngenxa yokudla

2. I-Anti-Ukuguga Nokuphila Isikhathi Eside

Amazinga e-MOTS-c ehla ngokuya ngeminyaka, futhi ukwengezwa kumagundane amadala kukhonjisiweukwandisa umthamo womzimba, thuthukisa umsebenzi we-mitochondrial, futhiukubambezela ukwehla okuhlobene neminyaka.
Ithuthukisa ukusebenza kokuzivocavoca futhiukukhuthazela kwemisiphangokuthuthukisa i-oxidative metabolism.

3. I-Mitochondrial kanye ne-Cellular Stress Protection

Iyathuthukisaukusinda kwamaselula ngaphansi kwengcindezi ye-metabolic noma ye-oxidativeizimo.
Khulisa ukubonakaliswa kwezakhi zofuzo ezihlobene neukulungiswa kwamaselula kanye ne-autophagy.

4. I-Cardiovascular and Neuroprotective Potential

Ucwaningo lokuqala luphakamisa ukuthi i-MOTS-c ingavikelaamaseli we-vascular endothelialfuthi unciphise izimpawu zokucindezeleka kwenhliziyo.
Izici ezingaba yi-neuroprotective ngokusebenzisaizindlela zokulwa nokuvuvukala kanye ne-antioxidativeziyaphenywa.

I-API Manufacturing kanye Nezimfanelo Zekhwalithi

At Iqembu leGentolex, wethuI-MOTS-c APIikhiqizwa kusetshenziswai-solid-phase peptide synthesis (SPPS)ngaphansi kwezimo eziqinile ezifana ne-GMP, eqinisekisa izinga eliphezulu, ubumsulwa, nokuzinza kocwaningo nokusetshenziswa kokwelapha.