Ibizo | MicAFung |
Inombolo ye-CAS | 235114-32-6 |
Ifomula yamangqamuzana | C56h71NNO23S |
Isisindo molecular | 1270.28 |
Inombolo ye-einec | I-1806241-263-5 |
Lo mkhiqizo ungowokufakwa kwe-intravenous. Ukuhlushwa kwe-plasma kufinyelela esilinganisweni ekugcineni kokufakwa, kanye nokuqedwa kwe-Half-Life amahora angama-13,9. Ukuhlushwa kweMicafungin esisekelweni, isibindi, izicubu zensizwa kanye nezinso kuphakeme kakhulu, kepha akutholakalanga ku-verebrospinal fluid. Ngemuva kokufakwa kwe-intravenous, kuhlanganiswe kakhulu esibindini futhi kufakwe ku-femeks nomchamo.
Umthamo onconyiwe wokwelashwa kwe-esophageal candidiasis ngu-150 mg ngosuku, kanye nethamo elinconyiwe lokutheleleka kokutheleleka kwe-candida ku-hematopoietic stem iziguli zokufakelwa kwamaseli ngosuku. Ngokusho kwemininingwane etholakalayo yomtholampilo, inkambo ephakathi yokwelashwa noma ukuvimbela lezi zifo ezimbili ezingenhla yizinsuku eziyi-15 nezinsuku eziyi-19, ngokulandelana. Umuthi ulungiselelwe futhi uvinjelwe ngosawoti ojwayelekile noma umjovo ongu-5% we-dextrose. Isikhathi sokuphatha kufanele okungenani sibe yihora eli-1, uma kungenjalo kulula ukukhiqiza ukusabela okungekuhle.
Ukuqothuka kwe-Plasma ephakeme ye-nifedipine kungandiswa ngo-42%, futhi uma kunesidingo, cabanga ukunciphisa umthamo we-nifedipine noma uyeke umuthi. Le ndawo ngaphansi kwejika lokuhlushwa le-plasma lokulwa nokwenqatshwa kwezidakamizwa uSirolimus wenqatshwa ngo-21%, futhi ukuncishiswa kwethamo le-sirolimus kufanele kubhekwe njengokufanele. Izidakamizwa ze-Antifungal, i-Clinical Pharmacology, ukusetshenziswa, ukuphendula okuphikisayo, njll. IMicafungin
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