I-Ipamorelin
I-Ipamorelin API
I-Ipamorelin iyi-hormone yokukhula ye-pentapeptide yokwenziwa ekhulula i-peptide (GHRP) eyakhiwe ngama-amino acid amahlanu (Aib-His-D-2-Nal-D-Phe-Ls-NH₂). Kuyi-agonist ekhethiwe ye-GHSR-1a enekhono lokuvuselela i-hormone yokukhula (GH) ngokucaciswa okuphezulu. Uma kuqhathaniswa nama-GHRP angaphambili (afana ne-GHRP-2 ne-GHRP-6), i-Ipamorelin ibonisa ukukhetha okungcono, ukuphepha nokuzinza kwe-pharmacological ngaphandle kokuthinta kakhulu amazinga amanye amahomoni afana ne-cortisol, i-prolactin noma i-ACTH.
Njenge-API ye-peptide ebhekwa kakhulu, i-Ipamorelin okwamanje isetshenziswa kabanzi ocwaningweni lokulwa nokuguga, ukuvuselelwa kwezemidlalo, ukungenelela kwe-osteoporosis, ukubuyisela ngemva kokuhlinzwa kanye nokulawulwa komsebenzi we-metabolic.
Ucwaningo kanye Nendlela Yokwenza
I-Ipamorelin ikhuthaza ukukhululwa kwe-hormone yokukhula engapheli (GH) kusukela ku-anterior pituitary ngokukhetha ngokukhetha i-hormone yokukhula secretion receptor (GHSR-1a) nokulingisa isenzo se-ghrelin. Izindlela zayo eziyinhloko ze-pharmacological zihlanganisa:
1. Khuthaza ukukhishwa kwe-GH
I-Ipamorelin ijabulisa kakhulu ngokukhetha i-GHSR-1a, ikhuthaza indlala ye-pituitary ukuthi ikhulule i-GH ngaphandle kokuthinta kakhulu amazinga e-ACTH noma e-cortisol, futhi inokuphepha okungcono kwe-endocrine.
2. Thuthukisa ukwakheka kwamaprotheni kanye nokulungiswa kwamaseli
Ngokwandisa amazinga e-IGF-1, ikhuthaza i-muscle cell anabolism, ithuthukisa ukulungiswa kwezicubu nokuvuselelwa kabusha, futhi ifanele ukukhanda ukuhlukumezeka, ukutakula kokuhlinzwa kanye nokwelashwa kwe-anti-muscle atrophy.
3. Thuthukisa umzimba kanye nokusabalalisa amafutha
I-GH inemiphumela yokuhlanganisa amafutha kanye nokuthuthukiswa kokuzwela kwe-insulin. I-Ipamorelin ingasiza ekulawuleni isimo se-metabolic futhi isetshenziselwa ucwaningo nge-metabolic syndrome kanye nokungenelela kokukhuluphala.
4. Thuthukisa ukuminyana kwamathambo kanye nokulwa nokuguga
I-GH/IGF-1 axis ingakhuthaza ukwakheka kwamathambo kanye ne-mineralization. I-Ipamorelin ibonisa isithembiso ku-anti-osteoporosis, ukuvuselelwa kwe-fracture kanye nokulwa nokuguga.
5. Thuthukisa isigqi se-circadian kanye nekhwalithi yokulala
Ukukhululwa kwe-GH kuvame ukuhambisana nokulala okujulile. Ucwaningo luye lwathola ukuthi i-Ipamorelin ingathuthukisa ngokungaqondile isakhiwo sokulala futhi ithuthukise ikhono lokubuyisela umzimba.
Izifundo zangaphambi komtholampilo kanye nokuqinisekisa ukusebenza kahle
Nakuba kusesesigabeni sokuqala somtholampilo / sokuqala, i-Ipamorelin ibonise ukuphepha okuhle nokusebenza kahle kwezilwane nezinye izifundo zabantu:
Amazinga e-GH akhuphuka kakhulu (izinga eliphakeme phakathi kwemizuzu engu-30, ehlala amahora ambalwa)
Awukho umphumela osobala we-pro-cortisol noma we-pro-ACTH, imiphumela ye-endocrine iyalawuleka kakhulu
Thuthukisa imisipha namandla (ikakhulukazi kumamodeli ezilwane ezindala)
Thuthukisa ukutakula kwangemva kokuhlinzwa kanye nesivinini sokulungisa izicubu
Ukwenyuka kwamazinga e-IGF-1 kusiza ukulungisa amaseli kanye nokusabela kwe-antioxidant
Ngaphezu kwalokho, i-Ipamorelin ihlanganiswe namanye ama-mimetics we-GHRH (njenge-CJC-1295) kwezinye izifundo zibonise imiphumela ye-synergistic, ngokuqhubekayo ithuthukisa ukukhululwa kwe-GH.
Ukukhiqizwa kwe-API nokuqinisekiswa kwekhwalithi
I-Ipamorelin API ehlinzekwe yi-Gentolex Group yethu ilungiselelwe kusetshenziswa i-high-standard **inqubo ye-peptide synthesis yesigaba esiqinile (SPPS)**, futhi ihlanzwa ngokuqinile futhi ihlolwe ikhwalithi, ifanele ucwaningo lwesayensi nokuthuthukiswa kanye nokusetshenziswa kwamapayipi okuqala ezinkampanini zemithi.
Izici zomkhiqizo zifaka:
Ukuhlanzeka ≥99% (ukuhlolwa kwe-HPLC)
Ayikho i-endotoxin, i-solvent eyinsalela ephansi, ukungcoliswa kwe-ion yensimbi ephansi
Nikeza ngesethi ephelele yamadokhumenti ekhwalithi: I-COA, umbiko wocwaningo lokuzinza, ukuhlaziywa kwe-spectrum yokungcola, njll.
Ukunikezwa kweleveli yegremu ~kilogram-leveli okwenziwa ngokwezifiso
