IButamoran Mesylate inyusa isisindo somzimba inzuzo, amazinga e-serum IGF-1 ne-GH

Ukufanisa

I-Ibramolen Mesylate iyisidakamizwa esisebenza njenge-heltone enamandla, ekhuthazayo, esishukumisayo sokukhuthaza ama-hormone, silingisa isenzo se-GH ukuvuselela ama-hormone ama-endocinaus.

Sebenza

I-Ibramolen Mesylate ikhonjiswe ukwandisa ukukhishwa kanye nokukhiqizwa kwamazinga we-plasma aqhubekayo athile ama-hormone afaka i-grom ne-insulin-like ukukhula factor 1 (IGF-1), kepha awathinti amazinga we-cortisol. Ukwelashwa okungaba khona njengamanje kusakhiwa kunciphisa amazinga wale homone, njengasezinganeni noma asebekhulile ngokuntuleka kokukhula kwama-hormone, futhi izifundo zabantu zikhombise ukwenyuka kwamamisipha amamisipha akhulile, okwenza kube ukwelashwa okuthe xaxa kwabantu abadala abadala. Iphinde iguqule imetabolism yamafutha omzimba, ngakho-ke kungahle kube nezicelo ekwelashweni kokukhuluphala.

Ezifundweni ze-Vivo

IButamonon Mesylate (5 mg / kg / usuku) imiphumela ebaluleke kakhulu yezilwane inzuzo yokuthola isisindo somzimba futhi yandisa amazinga e-serum IGF-1 ne-GH ezinjeni. I-IbutamorEN Meesylate iphumela ngaphandle kokwanda okuphambili kumazinga we-CSF IGF-1 noma i-GH ngezinsuku 7 noma 15 wesifundo. Amagundane okubonisa amacala ane-gh amabhlogo asebenza kwalawa ma-neurons ngu-Ibutamormon mesylate (50 μg, ip). Emacekeni angqongqozayo, bobabili i-GH ne-OCTREIDIDE bahluleka ukuvimba ukusebenza kwe-imesylate ye-Ibutamoran of arcuate neurons. Ukuphathwa kwama-Oral Oral of MK-0677 kuhlotshaniswa nokwanda okukhulu emazingeni aphansi ase-GH nase-IGF-I anakekelwa isikhathi sokwelashwa. Iphrofayili ye-GH elandela ukuphathwa kwe-MK-0677 iqukethe ukunyuswa kwe-EPisodic ngenhla kokulawula. UMK-0677 Ukhulisa kakhulu i-Peak GH ukugxila ngemuva kokuphathwa ngomlomo. I-MK-0677 iyi-peoterogue enamandla ye-Gh Gh gh edonsa ngokushesha, ukukhuphuka okuhlala isikhathi eside, okuhlala isikhathi eside kumazinga we-GH lapho kulawulwa ngomlomo noma i-IV