I-Hexarelin

I-Hexarelin API - Uhlolojikelele Lomkhiqizo

I-Hexareliniwukwenziwai-hormone yokukhula secretagogue peptide (GHS)futhi enamandlaI-GHSR-1a i-agonist, ithuthukiswe ukuze ikhuthazeukukhululwa kwe-endogenous growth hormone (GH).. Ingeka-umndeni we-ghrelin mimeticfuthi yakhiwe ama-amino acid ayisithupha (i-hexapeptide), enikeza ukuzinza okuthuthukisiwe kwe-metabolic kanye nemiphumela eqinile yokukhulula i-GH uma kuqhathaniswa nama-analog angaphambili afana ne-GHRP-6.

I-Hexarelin ifundelwa kabanzi ngezicelo zayo kui-endocrinology, ukuwohloka kwemisipha, ukulungiswa kwenhliziyo, nokwelapha okulwa nokuguga, ngenxa yekhono layo lokuphakamisa ngokwemvelo i-GH kanyeI-insulin-like growth factor 1 (IGF-1)amazinga ngaphandle kokwethula ngokuqondile amahomoni angaphandle.

Indlela Yokwenza

I-Hexarelin ibophezela ku-i-hormone yokukhula secretagogue receptor (GHSR-1a)ku-pituitary kanye ne-hypothalamus, elingisa isenzo se-i-ghrelin-ukulamba kwemvelo komzimba kanye nehomoni ekhulula i-GH.

Izenzo ezibalulekile zomzimba:

• Ivuselela ukukhishwa kwe-GH okuguquguqukayo

• Yandisa ukujikelezaI-IGF-1amazinga

• Iyakhuthazaimiphumela ye-anabolic(ukukhula kwemisipha, ukululama)

• Isekelai-fat metabolismfuthiukuvuselelwa kweseli

• Kungakhangisai-cardioprotectivefuthianti-apoptoticimiphumela

Ngokungafani namanye ama-peptide e-GHS, i-Hexarelin iyakwenzahhayi ukwandisa kakhulu i-cortisol noma i-prolactin, enikeza iphrofayili ye-endocrine ehlanzekile.

Ucwaningo kanye Namathuba Okwelapha

1. Ukukhula Nokubuyiselwa Kwemisipha

• Iyakhuthazaisisindo somzimba omncaneukuthuthukiswa

• Iyathuthukisaukulungiswa kwemisipha nokuvuselelwa

• Wafunda ei-cachexia, i-sarcopenia, kanye nokululama ngemva kokuhlinzwa

2. Ukuvikelwa Kwenhliziyo

• Ucwaningo lwangaphambi komtholampilo luyabonisangcono ukusebenza kwenhliziyongemuva kokulimala kwe-myocardial

• Yehlisai-fibrosis yenhliziyofuthi ithuthukisaingxenye ye-ventricular ejection yesokunxele

• Ukusetshenziswa okungenzeka kuukuhluleka kwenhliziyofuthiukuguga kwenhliziyoamamodeli

3. I-Fat Metabolism & Anti-Ukuguga

• Iyakhulai-lipolysisfuthi iyathuthukaukuzwela kwe-insulin

• Isekelaimithi yokulwa nokugugangokusebenzisa i-GH/IGF-1 i-axis stimulation

• Ingasiza ukunakekelaukuminyana kwamathambo kanye nempilo yamalunga

Izici ze-API (Gentolex Group)

• Ukuhlanzeka ≥ 99%

• Ikhiqizwe ngei-solid-phase peptide synthesis (SPPS)

• Amazinga afana ne-GMP, i-endotoxin ephansi kanye nezinsalela ze-solvent

• Ukunikezwa okuguquguqukayo:I-R&D kuya esikalini sezentengiso