I-Daptomycin 103060-53-3 yezifo ezithathelwanayo
Imininingwane Yomkhiqizo
| Igama | I-Daptomycin |
| Inombolo ye-CAS | 103060-53-3 |
| Ifomula yamangqamuzana | I-C72H101N17O26 |
| Isisindo samangqamuzana | 1620.67 |
| Inombolo ye-EINECS | 600-389-2 |
| Iphoyinti lokuncibilika | 202-204°C |
| Iphuzu elibilayo | 2078.2±65.0 °C (Kubikezelwe) |
| Ukuminyana | 1.45±0.1 g/cm3(Kubikezelwe) |
| Iphoyinti le-Flash | 87℃ |
| Izimo zokugcina | Kuvalwe endaweni eyomile, Gcina efrijini, ngaphansi kuka-20°C |
| Ukuncibilika | I-Methanol: i-soluble5mg/mL |
| I-acidity coefficient | (pKa) 4.00±0.10 (Kubikezelwe) |
| Ifomu | impushana |
| Umbala | engenambala ukuya kophuzi |
Omqondofana
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-L-4-abuny) ;N-[N-Decanoyl-L-Trp-D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-3-(2-aminobenzo-la-1)-Lxol; ecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R) -3-methyl-L-α- i-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone;DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Incazelo
I-antibiotic daptomycin iyi-cyclic lipopeptide antibiotic enesakhiwo esisha esikhishwe kumhluzi wokuvutshelwa we-Streptomyces (S. reseosporus), okuvimbela i-biosynthesis ye-bacterial cell wall peptidoglycan ngokuphazamisa ukuthuthwa kwama-amino acid kulwelwesi lweseli. Ukushintsha izici zolwelwesi lwe-cytoplasmic kungaphazamisa ukusebenza kolwelwesi lwebhaktheriya ngezindlela eziningi futhi kubulale ngokushesha amagciwane e-Gram-positive. Ngaphezu kokukwazi kwayo ukusebenza kumagciwane amaningi ahlobene ne-Gram-positive, i-daptomycin ibaluleke kakhulu ezinhlotsheni ezizimele ezibonise ukumelana ne-methicillin, i-vancomycin, ne-linezolid in vitro. Inomsebenzi onamandla, futhi le ndawo inemithelela ebaluleke kakhulu yomtholampilo ezigulini ezigula kakhulu. I-Eosinophilic pneumonia yisifo esingandile futhi esibi kakhulu esinezimpawu ezihlanganisa imfiva, ukukhwehlela, ukuphefumula kanzima, nobunzima bokuphefumula.
Umphumela we-Antibacterial
I-Daptomycin inomsebenzi omuhle we-bacteriostatic ngokumelene namagciwane ahlukahlukene amelana nama-antibiotic, njenge-MIC=0.06-0.5 μg/ml ye-Staphylococcus aureus engazweli yi-methicillin (MRSA), kanye ne-Staphylococcus aureus (MRSA) engazweli methicillin. I-MIC=0.0625～1μg/ml yebhaktheriya, i-MIC=0.12～0.5μg/ml ye-Staphylococcus epidermidis engazweli oxacillin, MIC=2.5μg/ml ye-enterococcus imelana kakhulu ne-aminoglycoside antibiotics, MIC/MIC=The GIM5 I-Enterococcus ingu-0.5～1μg/ml, kanti i-MIC ye-Enterococcus imelana nemithi elwa namagciwane e-glycopeptide ingu-1～2μg/ml.
