I-DAPPOMYCIN 103060-53-3 yezifo ezithathelwanayo
Imininingwane Yomkhiqizo
| Ibizo | Daptomycin |
| Inombolo ye-CAS | I-103060-53-3 |
| Ifomula yamangqamuzana | C72h101n17766 |
| Isisindo molecular | 1620.67 |
| Inombolo ye-einec | 600-389-2 |
| Iphuzu elincibilikayo | 202-204 ° C |
| Iphuzu elibilayo | 2078.2 ± 65.0 ° C (wabikezela) |
| Incekusana | 1.45 ± 0.1 g / cm3 (abikezelwe) |
| I-flash point | 87 ℃ |
| Izimo Zokugcina | Kuvalwe uphawu elomile, esitolo efrijini, ngaphansi -20 ° C |
| Ubuhlakaniselo | I-Methanol: Soluble5mg / ML |
| I-acidity coccifflity | (PKA) 4.00 ± 0.10 (abikezelwe) |
| Isithunzi | impushana |
| Umbala | Umbala ongenamkhawulo ophuzi |
Amanyanjana
N- [N- ; I-ECYL) -K-Tryptophyl-D-asparaginyl-L-α-threellglyclylly-l-asnithinyl-L-α-Aspartyllycly-d-seryl-l-α-aspartylglycyl-d-seryl- (3r) -3-puryl-l-α- glutamyl-α, 2-dianeino-γ-benzenenebutanoIcacacid (13-4) i-lactone; daptomycine; dapcin; dapcomycin, i-dapcin; daptomycinreadymadesoululuon; daptomycin (ly146032)
Ukufanisa
I-antibiotic Daptomycin yi-cyclic limonide antibiotic enesakhiwo esisha esikhishwe emhluzi we-reseptomyecces (S. Reseosporus), esivimbela i-biosynthesis ye-bacteromyer cell pollidoglycan ngokuphazamisa ukuthutha ama-amino acid kulwelwesi lwamaselula. Ukuguqula izakhiwo ze-cytoplasmic membrane kungaphazamisa ukusebenza kwe-bacterial membrane ngezindlela eziningi futhi kubulale ama-bacterium ane-gram. Ngaphezu kwekhono layo lokwenza ama-bacterium afanelekile emtholampilo afanelekile emtholampilo, i-daptomycin ebaluleke kakhulu kwizinhlobo ezihlukile ezikhombise ukumelana ne-methicillin, Vancomycin, ne-linezolid eVitro. Inomsebenzi onamandla, futhi le mpahla inemiphumela ebaluleke kakhulu yomtholampilo yeziguli ezithelelekile kakhulu. I-Eosinophilic Pneumonia iyisifo esingajwayelekile futhi esibi kakhulu esinezimpawu ezibandakanya umkhuhlane, ukukhwehlela, ukufushane komoya nobunzima bokuphefumula.
Umphumela we-antibacterial
I-DaptomyCin inomsebenzi omuhle we-bacteriostatic ngokumelene namagciwane ahlukahlukene alwa namagciwane, njenge-mic = 0.06-0.5 μg / ml nge-methicillin-starphylococcus aureus (MRSA), kanye ne-methilillin-statfyloccus aureus (MRSA). Mic = 0.0625 ~ 1μg / ml for bacteria, mic = 0.12 ~ 0.5μ / ml nge-oxafillin-starstraust epidermincus epidermincus epidermincus epidermincus epidermincus ethedermin-i-staphylococcus i-ententococcus i-antibooticvide antibiatis, mic = 2.5μ / ml ye-GMRBIA -I-MIC ye-Enterococcus I-0.5 ~ 1μg / ml, kanye ne-mic of ententococcus engavunyelwe ukumelana nama-antibiotic angu-1 ~ 2μ / ml.
