I-CJC-1295

I-CJC-1295 API

I-CJC-1295i-analogue ye-peptide yokwenziwa, efakwe esikhundleni se-tetraI-hormone yokukhula ekhulula i-hormone (GHRH), yakhelwe ukuvuselela futhi ugcine ukugcinwa kwe-endogenous growth hormone (GH). Ngokungafani ne-GHRH yomdabu, enesigamu sempilo emfushane, i-CJC-1295 ihlanganisa aUbuchwepheshe beDrug Affinity Complex (DAC)., ukuyivumela ukuthi ibophe ngokuhlanganyela ku-albumin egazini futhiandise uhhafu wempilo yayo ibe ngaphezu kwezinsuku eziyi-8. Lokhu okusha kwenza i-CJC-1295 aI-analogue ye-GHRH esebenza isikhathi esidengamandla amakhulu kuukulwa nokuguga, ukuntula ukukhula, ukulawulwa kwe-metabolic, ukuphazamiseka kokumosha imisipha, kanye nemithi yokuvuselela kabusha.

Indlela Yokwenza

I-CJC-1295 isebenza ku-I-GHRH receptoretholakala kumaseli e-somatotropic ku-anterior pituitary gland. Umsebenzi wayo webhayoloji ulingisa owe-GHRH yomdabu, kodwa ngesigamu sempilo enwetshiwe kakhulu ngenxa yokuguqulwa kwe-DAC. Lesi senzo esiqhubekayo sivumelaukukhululwa okuzinzile kwe-pulsatile kwe-GHkanye nokwanda kokukhiqizwa kweI-insulin-like growth factor 1 (IGF-1).

Izindlela eziyinhloko zifaka:

• Ukukhuthazwa kokugcinwa kwe-GH endo native

• Ukuphakama isikhathi eside kwamazinga e-IGF-1, ukusekela imiphumela ye-anabolic

• Akukho ukungezwani okuphawulekayonoma ukwehliswa ngokusetshenziswa okuqhubekayo

• I-lipolysis ethuthukisiwe, ukwakheka kwamaprotheni, nokuvuselelwa kabusha kwamaselula

Ngokucupha izindlela zomzimba ze-GH ne-IGF-1, i-CJC-1295 igwema izithiyo eziningi ezihambisana nokwelashwa kwe-GH exogenous, njengokungazweli kwe-receptor kanye nokukhathazeka kokuphepha.

Ucwaningo Lwezokwelapha kanye Namandla Omtholampilo

1. I-Growth Hormone Deficiency (GHD)

Ezivivinyweni zomtholampilo zesigaba sokuqala, i-CJC-1295 ibonise:

• Ukunyuka okuqhubekayoGHfuthiI-IGF-1amazinga kuze kufike6-10 izinsukungemva komjovo owodwa

• Yehlisiweumjovo imvamisauma kuqhathaniswa nama-analogues we-GHRH nsuku zonke noma imijovo ye-GH

• Ukuthobela isiguli okuthuthukisiwe nokuzinza kwe-hormonal

2. Ukwakheka Komzimba Nokugcinwa Kwemisipha

Ucwaningo lwezilwane nabantu lubonise ukuthi i-CJC-1295:

• Iyakhuthazaukuzuza kwemisipha ethambilefuthikunciphisa amafutha omzimba, ikakhulukazi amafutha e-visceral

• Iyathuthukisaukugcinwa kwe-nitrogen kanye nokuhlanganiswa kwamaprotheniemsipheni wamathambo

• Kungasiza ekululameni kusukai-sarcopeniakanye nezimo ezimosha imisipha

3. Anti-Ukuguga kanye Wellness Izicelo

Njengoba amazinga e-GH ne-IGF-1 ehla ngokwemvelo ngokukhula, i-CJC-1295 iya ngokuya ifundwa njengeukungenelela okulwa nokugugakuya:

• Thuthukisaizinga lokulalafuthiumthetho we-circadian rhythm

• Thuthukisaukunwebeka kwesikhumba, ukuminyana kwamathambo, futhiumsebenzi wokuzivikela komzimba

• Ukusekelaamandla metabolismfuthiukumelana nokukhathala

4. I-Metabolic Regulation

I-CJC-1295 ibonisa isithembiso ekukhulumeniukumelana ne-insulinkanye ne-metabolic syndrome:

• Iyathuthukaukusetshenziswa kweglucose

• Iyathuthukisai-lipid oxidationfuthiizicubu ze-adipose metabolism

• Ukusekelaukuphathwa kwesisindokubantu abakhuluphele noma abangaphambi kwesifo sikashukela

I-API Manufacturing kanye Nokulawula Ikhwalithi

At Iqembu leGentolex, wethuI-CJC-1295 APIikhiqizwa kusetshenziswai-solid-phase peptide synthesis (SPPS)futhi ihlanzwe kusetshenziswa i-HPLC ukuze kuzuzwe ubumsulwa obuphezulu kanye nokuvumelana kwe-batch-to-batch.

Ukucaciswa Okubalulekile:

• Ukuhlanzeka ≥ 99%(i-HPLC iqinisekisiwe)

• Izincibilikisi ezisalela eziphansi nezinsimbi ezisindayo

• Umzila we-endotoxin-free, non-immunogenic synthesis

• Itholakala kuamanani angokwezifiso: milligram kuya kukhilogremu esikalini

Izicelo kanye Namathuba Esikhathi esizayo

I-CJC-1295 ibhekwa njengenye yama-analogue e-GHRH asebenza isikhathi eside athembisayo, anezinhlelo zokusebenza ezingaba khona:

• Ukwelashwa kokuntuleka kwe-GH yabantu abadala

• Ukulawulwa kokwakheka komzimba ekukhuluphaleni nasekugugeni

• Ukuvuselelwa kusuka ekulahlekelweni kwemisipha noma ukuhlukumezeka

• Ukuthuthukiswa kokusebenza nokululama kuzilungiselelo zomtholampilo noma zezemidlalo

• Ukwelashwa okusekelayo ekukhathaleni okungapheli, i-fibromyalgia, nokungalingani kwe-neuroendocrine

Izivivinyo zomtholampilo eziqhubekayo zihlola ukusetshenziswa kwayo njengenye indlelai-recombinant GH, ikakhulukazi kubantu abafunayoukuphepha, ukuguqulwa kwama-hormone okuphila okwengeziwe.