I-Caspofungin yezifo ze-Antifungal
Imininingwane Yomkhiqizo
| Igama | I-Caspofungin |
| Inombolo ye-CAS | 162808-62-0 |
| Ifomula yamangqamuzana | I-C52H88N10O15 |
| Isisindo samangqamuzana | 1093.31 |
| Inombolo ye-EINECS | 1806241-263-5 |
| Iphuzu elibilayo | 1408.1±65.0 °C (Kubikezelwe) |
| Ukuminyana | 1.36±0.1 g/cm3(Kubikezelwe) |
| I-acidity coefficient | (pKa) 9.86±0.26 (Kubikezelwe) |
Omqondofana
CS-1171;Caspofungine;CASPOFUNGIN;CASPORFUNGIN;PneuMocandinB0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl -1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-;CaspofunginMK-0991;Aids058650;Aids-058650
Chemical Properties
I-Caspofungin kwakuyi-echinocandin yokuqala egunyazwe ukwelashwa kwezifo ezikhuntayo ezihlaselayo. Ukuhlolwa kwe-in vitro kanye ne-in vivo kuqinisekisile ukuthi i-caspofungin inomsebenzi omuhle wokulwa namagciwane ngokumelene namagciwane abalulekile angosomathuba-Candida kanye ne-Aspergillus. I-Caspofungin ingaphula udonga lwamaseli ngokuvimbela ukuhlanganiswa kwe-1,3-β-glucan. Ngokomtholampilo, i-caspofungin inomphumela omuhle ekwelapheni i-candidiasis ehlukahlukene kanye ne-aspergillosis.
Umphumela
(1,3) -D-glucan synthase iyingxenye eyinhloko ye-fungal cell wall synthesis, futhi i-caspofungin ingaba nomphumela we-antifungal ngokungavimbi ngokuncintisana le enzyme. Ngemuva kokuphathwa ngomjovo, ukugcwala komuthi we-plasma kwehla ngokushesha ngenxa yokusatshalaliswa kwezicubu, kulandelwa ukukhishwa kancane kancane komuthi esicutshini. I-Metabolism ye-caspofungin yanda ngomthamo okhulayo futhi yayihlobene nomthamo ngesikhathi sokuzinza ngemithamo eminingi. Ngakho-ke, ukuze kuzuzwe amazinga okwelapha asebenzayo futhi kugwenywe ukunqwabelana kwezidakamizwa, umthamo wokuqala wokulayisha kufanele unikezwe ulandelwe umthamo wesondlo. Lapho usebenzisa ama-inducers e-cytochrome p4503A4 ngasikhathi sinye, njenge-rifampicin, i-carbamazepine, i-dexamethasone, i-phenytoin, njll., kunconywa ukwandisa umthamo wokugcinwa kwe-caspofungin.
Izinkomba
Izinkomba ezigunyazwe yi-FDA ze-caspofungin zihlanganisa: 1. Imfiva ene-neutropenia: ichazwa ngokuthi: imfiva >38°C enenani eliphelele le-neutrophil (ANC) ≤500/ml, noma nge-ANC ≤1000/ml futhi kubikezelwa ukuthi ingancishiswa ibe ngaphansi kuka-500/ml. Ngokwezincomo ze-Infectious Diseases Society of America (IDSA), nakuba iziguli ezinemfiva eqhubekayo kanye ne-neutropenia ziye zelashwa ngama-antibiotic abanzi, iziguli ezisengozini enkulu zisanconywa ukuthi zisebenzise i-empiric antifungal therapy, okuhlanganisa i-caspofungin nezinye izidakamizwa ze-antifungal. . 2. I-candidiasis ehlaselayo: I-IDSA incoma i-echinocandins (njenge-caspofungin) njengesidakamizwa esikhethwayo se-candidemia. Ingasetshenziswa futhi ukwelapha amathumba angaphakathi kwesisu, i-peritonitis kanye nezifo zesifuba ezibangelwa ukutheleleka kwe-Candida. 3. I-Esophageal candidiasis: I-Caspofungin ingasetshenziswa ukwelapha i-candidiasis ye-esophageal ezigulini ezine-refractory noma ukungabekezelelani kwezinye izindlela zokwelapha. Ucwaningo oluningi luthole ukuthi umphumela wokwelapha we-caspofungin uqhathaniswa nowe-fluconazole. 4. I-aspergillosis ehlaselayo: I-Caspofungin igunyazwe ukwelashwa kwe-aspergillosis ehlaselayo ezigulini ezinokungabekezelelani, ukumelana, nokungasebenzi kwesidakamizwa esiyinhloko se-antifungal, i-voriconazole. Nokho, i-echinocandin ayinconywa njengokwelashwa komugqa wokuqala.
