I-CaspoFungin izifo zangelifoli
Imininingwane Yomkhiqizo
| Ibizo | I-Caspofungin |
| Inombolo ye-CAS | 162808-62-0 |
| Ifomula yamangqamuzana | C52h88n10o15 |
| Isisindo molecular | 1093.31 |
| Inombolo ye-einec | I-1806241-263-5 |
| Iphuzu elibilayo | 1408.1 ± 65.0 ° C (wabikezela) |
| Incekusana | 1.36 ± 0.1 g / cm3 (abikezelwe) |
| I-acidity coccifflity | (PKA) 9.86 ± 0.26 (Ebikezelwe) |
Amanyanjana
CS-1171; I-Caspofungine; I-Caspofungin; CaspoFungulin; I-Pneumocandinb0,1 - [4r, 5s) -5 - [2-Aminoethyl) -N2- (10,12-DIMETYL -1-OngweTetradecyl) -4-hydroxy-l-ornithine] -5 - [3r) -3-hydroxy-l-ornithine] -; Caspofunginmk-09915; AIDS058650; AIDS-058650
Izakhiwo Zamakhemikhali
I-CaspoFungin kwakuyi-echinocandin yokuqala evunyelwe yokwelashwa kwezifo ezihlaselayo fungal. E-vitro nasezihlotsheni ze-vivo ukuqinisekisile ukuthi i-Caspofungin inomsebenzi omuhle wokulwa nama-antibacterial ngokumelene namathuba abalulekile amathuba akhona-uCandida ne-Aspergillus. I-CaspoFungin ingaqhuma odongeni lweseli ngokuvimbela ukuhlanganiswa kwe-1,3-β-glucan. Ngokwenyama, i-Caspofungin inomphumela omuhle ekwelashweni kwama-candidiasis ahlukahlukene kanye ne-aspergillosis.
Umphumela
. Ngemuva kokuphathwa kwe-intravenous, ukugxilisa izidakamizwa ze-plasma kulahla ngokushesha ngenxa yokusatshalaliswa kwezicubu, kulandelwa ukudedelwa kwezidakamizwa kancane kancane kusuka ezicutshini. I-Metabolism ye-Caspofungin yanda ngodosi okhulayo futhi yahlobene nodosi ngesikhathi sokuqina kwesimo semithamo eminingi. Ngakho-ke, ukuze kufinyelelwe amazinga asebenzayo okulapha futhi ugweme ukunqwabelana kwezidakamizwa, umthamo wokuqala wokulayisha kufanele uphathwe ulandelwa umthamo wesondlo. Lapho usebenzisa i-Cytochrome P4503A4 abashayeli ngasikhathi sinye, njenge-Rifampicin, Carbamazepine, Dexamethasone, Phenytoin, njll., Kunconywa ukukhulisa umthamo we-Caspofungin.
Izinkomba
Izinkomba ezivunyiwe ze-FDA ze-Caspofungin zifaka: 1. I-Neurropenia: Kuchazwa ngokuthi: Umkhuhlane> 38 Ngokwezincomo ze-Antlectious Diases Society of America (IDSA), yize iziguli eziphikelelayo kanye ne-neutropenia ziphathwe ngemithi ebanzi, iziguli ezinobungozi obukhulu zisanconywa ukusebenzisa i-Empiric AntiFungal Therapy, kufaka phakathi iCaspofungin kanye neminye imishanguzo ye-antifungal. . 2. I-CANSIVITIVE CANSIDISISIS: IDSA incoma ama-echinocandin (njenge-Caspofungin) njengomuthi wokuzikhethela we-candidemia. Ingasetshenziswa futhi ukwelapha ama-absserces we-intra-absossocial, i-peritonitis kanye nezifo zesifuba ezibangelwa ukutheleleka kukaCandida. 3. I-esophageal candidiasis: I-Caspofungin ingasetshenziselwa ukwelapha ama-esophageal candidiasis ezigulini ezinokubumbana noma ukungabekezelelani kwezinye izindlela zokwelapha. Izifundo eziningana zithole ukuthi umphumela wokwelapha we-Caspofungin uqhathaniswa nele-fluconazole. I-4. I-Aspergillosis: I-CaspoFungin ivunyelwe ukwelashwa kwe-aspergillosis ehlaselayo ezigulini ngokubonakala, ukumelana nokungasebenzi kahle kwezidakamizwa eziphambili ze-antifungal, iVoriconazole. Kodwa-ke, i-echinocandin ayinconywa njengokulashwa komugqa wokuqala.
