I-Cagrilintide

Incazelo emfushane:

I-Cagrilintide iwukwenziwa, i-amylin receptor agonist yokwenziwa isikhathi eside eyenzelwe ukwelapha ukukhuluphala kanye nokuphazamiseka kwe-metabolic okuhlobene nesisindo. Ngokulingisa i-hormone yemvelo i-amylin, isiza ukulawula isifiso sokudla, ukuphuma kancane kwesisu, nokuthuthukisa ukusutha. I-high-purity API ye-Cagrilintide ikhiqizwa ngokusebenzisa amakhemikhali futhi ihlangabezana nezindinganiso zebanga lezemithi, okuyenza ifanelekele ukusetshenziswa ekwakhiweni kokulawulwa kwesisindo okuthuthukisiwe.

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

I-Cagrilintide API

I-Cagrilintideithatha isikhathi eside, ihlanganiswe ngamakhemikhalii-amylin receptor agonist, ithuthukiswe njengendlela yokwelapha eyinoveli yeukukhuluphala kanye nokuphazamiseka kwe-metabolic okuhlobene nesisindo. Yenzelwe ukulingisa imiphumela yei-amylin yomuntu, i-hormone ehlanganiswe ne-insulin ngamaseli e-pancreatic β, edlala indima ebalulekile ekulawuleni ukudla okudlayo, ukuphuma kwesisu, nokusutha.

I-Cagrilintide ithuthukiswa njenge-Ukwelashwa ngomjovo kanye ngeviki, enikeza isixazululo ethembisa kakhuluukuphathwa kwesisindo esingamahlalakhona, ikakhulukazi uma isetshenziswa kuinhlanganisela ne-GLP-1 receptor agonistsnjengeI-Semaglutide.

Indlela Yokwenza

I-Cagrilintide isebenzisa imiphumela yayo yokwelapha ngokubophezela futhi isebenzeama-amylin receptors, okuholela ku-:

Ukucindezela ukudla
Ukuchithwa kwesisu okubambezelekile, okwandisa umuzwa wokugcwala
Ukwehliswa kwama-calories nokukhuphuka kokusutha

Lokhu kulawulwa kwezindlela eziningi zokudla kwenza kube ikhandidethi elifanele lokuphathaukukhuluphala kanye nezingozi ezihlobene ne-cardiometabolic.

Ucwaningo kanye Nemininingwane Yomtholampilo

I-Cagrilintide ibonise imiphumela ethembisayo ezivivinyweni ezimbalwa zomtholampilo, okuhlanganisaIzifundo zeSigaba 2 ezenziwa nguNovo Nordisk:

Lapho isetshenziswayedwa, Cagrilintide iholelaukuncipha kwesisindo okuncike kumthamo, kuze kufikeUkunciphisa umzimba ngo-10.8%.ngaphezu kwamaviki angama-26 kubantu abakhuluphele.
Ninikuhlanganiswe ne-Semaglutide, umphumela wokulahlekelwa isisindo uthuthukiswa kakhulu-ukufezaukuncipha okukhulu kwesisindo somzimba kunanoma iyiphi i-ejenti yodwa.
Kubonisiweukubekezelelana okuhlefuthiiphrofayili yokuphepha eqhubekayo, izehlakalo ezimbi kakhulu kuba izimpawu ezithambile zesisu.

Le ndlela yokuhlanganisa iyingxenye eyinhloko yohleloipayipi lezidakamizwa ezilwa nokukhuluphala kwesizukulwane esilandelayo, eqondise izindlela eziningi zokusutha (i-amylin + GLP-1).

Ikhwalithi ye-API kanye Nokukhiqiza

EyethuI-Cagrilintide API:

Ikhiqizwa ngokusebenzisa i-Advancedi-solid-phase peptide synthesis (SPPS)ngokuhlanzeka okuphezulu nokuzinza kwamakhemikhali
Yakhelweukuthuthukiswa kokwakheka komjovo
Ihlangana namazwe ngamazweamazinga emithi (ICH, GMP, FDA)
Iyatholakala kuukulinga ukukhiqizwa kwezinga lezentengiso, ifanele ukusetshenziswa komtholampilo kanye nezimboni

Amandla Okwelapha

I-Cagrilintide imele i-aindlela inoveliekulawuleni isisindo ngaphezu kwe-GLP-1 monotherapy. Iphrofayili yayo yesenzo esihambisanayo iyenza ifanelekele:

Ukukhuluphala ngokweqile kanye neziguli ezikhuluphele ngokweqile(unesifo sikashukela noma ongenaso)
Ukwelapha okuhlangeneukuze unciphise isisindo
Ukuthuthukiswa kwekusasa kuI-metabolic syndrome kanye ne-prediabetes