I-BPC-157
I-BPC-157 API
I-BPC-157 (igama eligcwele: Inhlanganisela Yokuvikela Umzimba 157) iyi-peptide emfushane yokwenziwa eyakhiwe ngama-amino acid ayi-15, etholakala ekulandelaneni kwamaprotheni emvelo avikelayo kujusi yesisu somuntu. Ibonise amandla abanzi okulungisa izicubu kanye namandla okulwa nokuvuvukala ezifundweni zokuhlola futhi ibhekwa kabanzi njengekhandidethi lesidakamizwa se-peptide esisebenza ngokuningi esithembisayo.
Njengesithako esisebenzayo semithi (i-API), i-BPC-157 isetshenziswe emikhakheni eminingi yocwaningo lwesayensi emhlabeni wonke ukuhlola umsebenzi wayo wezinto eziphilayo emgudwini wamathumbu, uhlelo lwe-musculoskeletal, uhlelo lwezinzwa, uhlelo lwenhliziyo nemithambo yegazi kanye nokulungiswa kwezicubu ezithambile, ikakhulukazi ekulungiseni ukuhlukumezeka kanye nokucwaninga okulwa nokuvuvukala.
Ucwaningo kanye nendlela yokusebenza kwemithi
I-BPC-157 iye yacwaningwa kabanzi, ikakhulukazi ekuhlolweni kwezilwane ze-vivo kanye namamodeli e-in vitro cell, futhi kutholakale ukuthi inemiphumela ewumnyombo elandelayo yezokwelapha:
1. Ukuvuselelwa kwezicubu nokulungisa ukuhlukumezeka
Ithuthukisa i-tendon, ligament, bone and soft tissue regeneration, futhi ingathuthukisa i-angiogenesis (i-angiogenesis).
Sheshisa ukuphulukiswa kwesilonda, ukulungiswa kwangemva kokuhlinzwa kanye nokululama kokulimala kwezicubu ezithambile, okuye kwaqinisekiswa kumamodeli ezilwane njengokugqabuka kwe-tendon, ukuqina kwemisipha, nokuphuka.
2. Ukuvikelwa nokulungiswa kwamathumbu
Kumamodeli anjenge-gastric ulcer, enteritis, colitis, i-BPC-157 inomphumela obalulekile wokuvikela ulwelwesi lwamafinyila.
Ingakwazi ukumelana nokulimala kwamathumbu okubangelwa izidakamizwa ezingezona ukuvuvukala (ama-NSAID) futhi ikhuthaze ukuphulukiswa kwe-mucosal yamathumbu.
3. I-Anti-inflammatory kanye ne-immunomodulatory
Ilawula ibhalansi yesimiso somzimba sokuzivikela ezifweni ngokuvimbela izici ezivusa ukuvuvukala (njenge-TNF-α, IL-6) kanye nokulawula izici eziphikisana nokuvuvukala.
Inenani elingaba khona njengokwelashwa okuyisizayo kwezifo ezivuvukalayo ezingapheli ezifana ne-**rheumatoid arthritis nesifo samathumbu esivuvukalayo (IBD)**.
4. I-Neuroprotection kanye ne-neurogeneration
Kumamodeli ngemva kokulimala komgogodla, ukungqubuzana kwezinzwa, kanye nezenzakalo ze-cerebrovascular, i-BPC-157 ingakhuthaza ukuvuselelwa kwezinzwa futhi inciphise ukulimala kwezinzwa.
Ingalwa nezinkinga emkhakheni we-neuropsychiatric ezifana nokukhathazeka, ukudangala, nokuncika otshwaleni (isigaba sokuhlola).
5. Ukuvikelwa kwenhliziyo nemithambo yegazi
I-BPC-157 ingathuthukisa ukungena kwemithambo futhi ikhuthaze ukulungiswa kwe-microvascular, futhi kukholakala ukuthi inomphumela omuhle ezifweni ezinjenge-myocardial ischemia, i-venous thrombosis, nokulimala komthambo.
Imiphumela yocwaningo lokuhlola kanye ne-preclinical
Nakuba i-BPC-157 ingakagunyazwa kabanzi ngemithi yomuntu, ibonisiwe ekuhlolweni kwezilwane:
Ukusheshisa okuphawulekayo kwesikhathi sokulungisa izicubu (njengokusheshisa okungu-50% kokuphulukiswa kwe-tendon)
Yehlisa kakhulu izigameko zokuphuma kwegazi esiswini, ukulimala emathunjini kanye nezilonda emathunjini
Thuthukisa ukubuyiswa kwe-nerve conduction futhi uthuthukise umsebenzi wendawo engenalutho
Khulisa izinga le-angiogenesis kanye ne-granulation tissue formation
Ngenxa yale miphumela, i-BPC-157 isiba ingqamuzana elibalulekile locwaningo emkhakheni wokubuyisela emuva kwenhlekelele, ukulimala kwezemidlalo, izifo zesisu, kanye nezifo ze-neurodeergenerative.
Ukukhiqizwa kwe-API nokulawulwa kwekhwalithi
I-BPC-157 API ehlinzekwa yi-Gentolex Group yethu yamukela inqubo ye-solid phase synthesis (SPPS) futhi ikhiqizwa ngaphansi kwezimo ze-GMP. Inezici ezilandelayo:
Ukuhlanzeka okuphezulu: ≥99% (ukutholwa kwe-HPLC)
Izinsalela zokungcola okuphansi, akukho endotoxin, akukho ukungcoliswa kwensimbi esindayo
Ukuzinza kweqoqo, ukuphindaphinda okuqinile, ukusetshenziswa kwezinga lomjovo lokusekela
Sekela ukunikezwa kwezinga legram nekhilogremu ukuze kuhlangatshezwane nezidingo zezigaba ezahlukene ukusuka ku-R&D kuya kwezezimboni.
