Zilebesiran

I-Zilebesiran (API)

Isicelo socwaningo:
I-Zilebesiran API iyi-RNA encane ephazamisayo yophenyo (siRNA) eyenzelwe ukwelapha umfutho wegazi ophakeme. Ihlose iI-AGTisakhi sofuzo, esihlanganisa i-angiotensinogen—ingxenye eyinhloko yesistimu ye-renin-angiotensin-aldosterone (RAAS). Ocwaningweni, i-Zilebesiran isetshenziselwa ukutadisha izindlela zokuthulisa izakhi zofuzo zokulawula umfutho wegazi wesikhathi eside, ubuchwepheshe bokulethwa kwe-RNAi, kanye nendima ebanzi yomzila we-RAAS ezifweni zenhliziyo nemithambo yegazi.

Umsebenzi:
I-Zilebesiran isebenza ngokuthulaI-AGTI-mRNA esibindini, okuholela ekunciphiseni ukukhiqizwa kwe-angiotensinogen. Lokhu kuholela ekwehleni komfula kumazinga e-angiotensin II, okusiza ukwehlisa umfutho wegazi ngendlela eqhubekayo. Njenge-API, i-Zilebesiran inika amandla ukuthuthukiswa kwemithi yokwelapha ethatha isikhathi eside, engaphansi kwe-subcutaneous ye-antihypertensive enamandla okwenziwa kwekota noma kabili ngonyaka, enikeza ukubambelela okuthuthukisiwe nokulawulwa komfutho wegazi.