I-Tirzepatide iyinoveli, i-insulinotropic polypeptide (GIP) esebenza kabili esebenza ngeglucose ne-glucagon-like peptide-1 (GLP-1) receptor agonist. Imele intuthuko enkulu ekwelapheni uhlobo lwesifo sikashukela sohlobo 2 futhi ibonise imiphumela ethembisayo ekulawuleni isisindo. I-Tirzepatide injection powder iyifomu lezemithi elisetshenziselwa ukulungisa isisombululo sokuphathwa kwe-subcutaneous.
Indlela Yokwenza
I-Tirzepatide isebenza ngokwenza kokubili ama-receptors e-GIP kanye ne-GLP-1, abambe iqhaza ekulawuleni amazinga kashukela egazini kanye nesifiso sokudla. I-agonism emibili inikeza imiphumela eminingi enenzuzo:
Ukukhiqizwa Kwe-insulin Okuthuthukisiwe: Ivuselela ukukhishwa kwe-insulin ngendlela encike kushukela, isiza ukwehlisa amazinga kashukela ngaphandle kokubanga i-hypoglycemia.
Ukukhishwa Kwe-Glucagon Ecindezelwe: Yehlisa ukukhiqizwa kwe-glucagon, i-hormone enyusa amazinga kashukela egazini.
I-Appetite Regulation: Ikhuthaza ukusutha futhi inciphisa ukudla, okunomthelela ekwehleni kwesisindo.
I-Slowed Gastric Emptying: Ibambezela ukuphuma kwesisu, okusiza ekulawuleni ukukhuphuka koshukela wegazi ngemuva kokudla.
Ukusetshenziswa Okugunyaziwe
Njengezibuyekezo zakamuva, i-Tirzepatide igunyazwe iziphathimandla ezilawulayo ezifana ne-US Food and Drug Administration (FDA) yokwelashwa kohlobo 2 lwesifo sikashukela. Iphinde iphenywe ngokusetshenziswa kwayo ekulawulweni kokukhuluphala.
Izinzuzo
Ukulawula I-Glycemic Okusebenzayo: Ukuncipha okukhulu kumazinga e-HbA1c.
Ukunciphisa Isisindo: Ukunciphisa isisindo esikhulu, okuwusizo ezigulini ezinesifo sikashukela sohlobo 2 kanye nokukhuluphala.
Izinzuzo zenhliziyo nemithambo yegazi: Intuthuko engaba khona ezicini eziyingozi zenhliziyo, nakuba izifundo eziqhubekayo zisahlola lesi sici.
Ukunethezeka: Umthamo kanye ngeviki uthuthukisa ukubambelela kwesiguli uma kuqhathaniswa nemithi yansuku zonke.
Engase Engase Side Effects
Nakuba i-Tirzepatide ivame ukubekezelelwa kahle, abanye abasebenzisi bangase babe nemiphumela emibi, kuhlanganise:
Izinkinga zeGastrointestinal:
Isicanucanu, ukuhlanza, isifo sohudo, nokuqunjelwa kuvamile, ikakhulukazi phakathi nezigaba zokuqala zokwelashwa.
Ingozi ye-Hypoglycemia: Ikakhulukazi uma isetshenziswa ngokuhlangana neminye imithi yokwehlisa ushukela.
I-Pancreatitis: Okungavamile kodwa kubi kakhulu, okudinga ukunakekelwa ngokushesha uma kuvela izimpawu ezinjengobuhlungu besisu obukhulu.
Ukulungiselela Nokuphatha
I-Tirzepatide injection powder idinga ukuphinda ihlanganiswe ne-solvent efanelekile (evame ukunikezwa kukhithi) ukwenza isisombululo sokujova. Isixazululo esihlanganisiwe kufanele sicace futhi singabi nezinhlayiya. Ilawulwa ngaphansi kwesikhumba esiswini, ethangeni, noma engalweni engenhla.