I-Tianestine yohlelo lwe-5-HT, sedation, anti-acetylcholine kanye ne-cardiotioxity for depression
Imininingwane Yomkhiqizo
| Ibizo | Uhlobo lwethayiya |
| Inombolo ye-CAS | 1224690-84-9 |
| Ifomula yamangqamuzana | C21h27clNN2O8S2 |
| Isisindo molecular | 535.02 |
| Iphuzu elincibilikayo | 129-131 ° C |
| Iphuzu elibilayo | 609.2ºC ngo-760 mmhg |
| Ubumsulwa | 99% |
| Ukubeka | Kuvalwe e-Dry, lokushisa legumbi |
| Isithunzi | Impushana |
| Umbala | Okumhlophe |
| Ukufaka ndawonye | Isikhwama se-Aluminium + Aluminium |
Amanyanjana
Thm; tianestinehemisulfatemonohydrate (thm); I-Tianestinehemisulfatehydrate; I-Tongkangzuo; tianespininesfateatewoohydate; tineptinesfatepterfate; tineptinesfatianepfate; tineptinesfateptinenenfate; tineptinesfateptinepfate; tineptinesphatepder / tianeptins ulfate
Umphumela wekhemisi
Umphumela wekhemisi
1. Indlela yokudla okune-antidepressant yalo mkhiqizo yehlukile kwaleyo ye-TCA yendabuko. Kungakhuphula ukuthandwa kwe-5-HT ku-synaptic Cleft, kepha kunomthelela obuthakathaka ekuphindaphindweni kwe-5-HT ne-NA. Ingaba nomphumela wokuthuthukisa ukuhanjiswa kwe-neuronal okungu-5-HT. Akunakuqhathaniswa nama-receptors, H1, α1 kanye í2-na receptors.
2. Ukusebenza kwe-antideressured kwalo mkhiqizo kuyafana nalokho kwe-TCA, futhi ukuphepha kwayo nokubekezelelana kungcono kune-TCA (TricyClic AntidePsressions). Ukusebenza kahle kwalo mkhiqizo kuyafana nalokho kwe-SSRI Fluoxetine.
3 Khulisa ukubuyiselwa kwe-5-hydroxyrytamine ngama-neurons ku-cerebral cortex kanye ne-hippocampus.
Ucwaningo lwe-toxicology
- Ukuhlolwa kobuthi be-acute, ukuzithoba kanye nobuthi be-Ubuthi be-Ubuthi: Akukho zinguquko ku-biology, umsebenzi wesibindi, i-anatomy ye-pathological.
- Ubuthi bokuzala kanye nokuhlolwa kweTeratogenicity: I-Tianeptine ayinamthelela emandleni okuzala kwabazali abaphathiswe kanye nasezinkuzane.
- Ukuhlolwa kwe-Mutagenicity: I-Tianeptine ayinawo umphumela we-mutagenic.
Umphumela wecala
- Ubuhlungu be-epigastric, ubuhlungu besisu, umlomo owomile, i-anorexia, isicanucanu, ukugabha, ukuqunjelwa, ukuthomba;
- Ukuqwasha, ukozela, amaphupho amabi, ubuthakathaka;
- I-Tachycardia, ama-extrasystoles, izinhlungu zemvelo;
- Isiyezi, ikhanda, ukuphelelwa amandla, ukuthuthumela, ukugcwala kobuso;
- Ukufushane komoya, umuzwa wokuxinana emphinjeni;
- i-myalgia, izinhlungu zangemuva, njll.
