I-Tadalafil 171596-29-5 ukwelapha ukungasebenzi kwe-erectile emadodeni

I-Tadalafil (Tadalafil, iTadalafil) inefomula ye-molecular of C22h19N3O4 kanye nesisindo samangqamuzana esingu-389.4. Kusetshenziswe kabanzi ekwelapheni ukwelashwa kwabesilisa kwe-erectile dysfunction kusukela ngo-2003, negama lokuhweba elithi cialis (cialis). NgoJuni 2009, i-FDA yavunywa uTadalafil e-United States ngokwelashwa kweziguli nge-hypertension ye-pulmonary arterial hypertrension (pah) ngaphansi kwegama lokuhweba i-adcirca. UTadalafil wethulwa ngo-2003 njengesidakamizwa sokwelashwa kwe-Ed. Kuthatha umphumela imizuzu engama-30 ngemuva kokuphathwa, kepha umphumela wayo omuhle kakhulu ngu-2h ngemuva kokuqala kwesenzo, futhi umphumela ungahlala ku-36h, futhi umphumela wayo awuthintekile ngokudla. Umthamo we-tadalafil uneminyaka eyi-10 noma engama-20 mg, umthamo wokuqala onconyiwe ngu-10 mg, futhi umthamo uguqulwa ngokuya ngempendulo yesiguli kanye nokuphendula okunzima. Ucwaningo lwangaphambi kwemakethe lukhombisile ukuthi ngemuva kokuphathwa ngomlomo kwe-TADALAFAFIL amasonto ayi-12, amanani asebenzayo angama-67% nama-81%, ngokulandelana. Ucwaningo oluningi lukhombisile ukuthi uTadalafil unokusebenza kahle ekwelashweni kwe-Ed.

I-Erectile dysfunction: I-Tadalafil iyindlela ekhethiwe ye-phosphodiesterase yohlobo 5 (PDE5) njenge-Sildenafil, kepha isakhiwo sawo sehlukile kokugcina, futhi ukudla okunamafutha amaningi akuphazamisi ukumuncwa kwayo. Ngaphansi kwesenzo sokukhuthaza ngokobulili, i-nitric oxide synthase (NOS) e-penile nerve ukuphela namaseli we-vascur endothelial actialzes the synthesis we-nitric oxide (cha) kusuka ku-substrate l-arginine. Akukho ukwenza kusebenze i-cyclase cyclase, eguqula i-genosine triphosphate ibe yi-cyclic guanosine monophosphate (CGMP), okuholela ekwehleni kwe-calcium ions kuma-celcium ions kumaseli we-calcium abushelelezi kumaseli emisipha abushelelezi, okubangela ukwamukelwa kwe-corpus casernosum ngenxa yokuphumula kwemisipha ebushelelezi. Uhlobo lwePhosphoDesterase 5 (PDE5) luhlanza i-CGMP ibe yimikhiqizo engasebenzi, yenza ipipi libe yisimo esibuthakathaka. UTadalafil uvimbela ukonakaliswa kwe-PDE5, okuholela ekuqongeleleni kwe-CGMP, evumisana nemisipha ebushelelezi ye-Corpus Casernosum, okuholela e-penile erection. Njengoba ama-nitrate awakho abanikeli, ukusetshenziswa okuhlangene ne-tadalafil kuzokhulisa kakhulu izinga le-CGMP futhi kuholele ekuxineni okukhulu. Ngakho-ke, ukusetshenziswa okuhlanganisiwe kwalokhu okuhlanganisiwe kungqubuzana ngokuzilolonga emtholampilo.

UTadalafil usebenza ngokuvimbela ama-PDes. I-GMP i-decinod decino, ukusetshenziswa okuhlanganisiwe okuhlangene nama-nitrate kungadala ukwehla okukhulu kwengcindezi yegazi futhi kwandise ubungozi bokuvumelanisa. Abayi-Cy3pa4 abahlukumezayo bazonciphisa i-bioavailability yeTadanafil, kanye nenhlanganisela nge-Rifampicin, i-CICETIDINE, i-Erythromycin, i-ITRACOn, i-ITracon, i-Itracon, i-ITracon, i-ITracon, Kuze kube manje, ayikho imibiko yokuthi amapharamitha we-Pharmacokinetic alo mkhiqizo athintwa ukudla notshwala.