I-Ste-γ-Glu-AEEA-AEEA-OSU

I-Ste-γ-Glu-AEEA-AEEA-OSU

I-Ste-γ-Glu-AEEA-AEEA-OSU iyingqamuzana yokwenziwa ye-lipidated linker eyenzelwe ukulethwa kwezidakamizwa okuhlosiwe kanye nama-antibody–drug conjugates (ADCs). Ifaka umsila we-stearoyl (Ste) we-hydrophobic, i-γ-glutamyl eqondiwe motif, izikhala ze-AEEA zokuguquguquka, kanye neqembu le-OSu (NHS ester) lokuhlanganisa kahle.

 
Ucwaningo Nezicelo:

Isetshenziswa ku-prodrug synthesis ehlosiwe kanye nomklamo we-nanocarrier

Ithuthukisa ukusebenzisana kwe-cell membrane kanye nokuthatha izidakamizwa

Ihambisa okunamathiselwe kokulayisha okukhokhelwa kwesayithi okuqondene nama-peptide, amasosha omzimba, noma abathwali

Izici Zomkhiqizo (Gentolex Group):

Ukuhlanzeka okuphezulu, i-ester ye-NHS elungele ukuhlanganisa

Ifanele i-bioconjugation kanye nocwaningo lokulethwa okuhlosiwe

I-Ste-γ-Glu-AEEA-AEEA-OSU ilungele ukuthuthukiswa kwesistimu yokulethwa kwezidakamizwa ezinembayo.