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Isithombe Esifakiwe Semaglutide
  • I-Semaglutide

I-Semaglutide

Incazelo emfushane:

I-Semaglutide iyi-agonist esebenza isikhathi eside ye-GLP-1 esetshenziselwa ukwelashwa kwesifo sikashukela sohlobo 2 kanye nokuphathwa kwesisindo esingapheli. I-API yethu ye-Semaglutide ephezulu ye-Purity ikhiqizwa ngokusebenzisa amakhemikhali ahlanganisiwe, angenawo amaprotheni amaseli abamba kanye nezinsalela ze-DNA, iqinisekisa ukuphepha okuhle kakhulu kwe-biosafety kanye nekhwalithi engaguquki. Ngokuhambisana nemihlahlandlela ye-FDA, umkhiqizo wethu uhlangabezana nemikhawulo eqinile yokungcola futhi usekela ukukhiqizwa kwenani elikhulu.


Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Semaglutide API

I-Semaglutide iyi-synthetic glucagon-like peptide-1 (GLP-1) receptor agonist esebenza isikhathi eside, eyenzelwe ukwelapha uhlobo lwesifo sikashukela sohlobo 2 nokukhuluphala. Iguquliwe ngokwesakhiwo ukuze imelane nokuwohloka kwe-enzymatic futhi ithuthukise isigamu sempilo, i-Semaglutide ivumela i-dosing elula kanye ngesonto, ithuthukisa kakhulu ukunamathela kwesiguli.

EyethuSemaglutide APIikhiqizwa ngenqubo yokwenziwa ngokugcwele, esusa izingozi ezihlobene nezinhlelo zokubonisa izinto eziphilayo, njengeprotheni yeseli eliphethe noma ukungcoliswa kwe-DNA. Yonke inqubo yokukhiqiza isithuthukisiwe futhi yaqinisekiswa esikalini sekhilogremu, ihlangabezana nezimfuneko zekhwalithi eziqinile ezishiwo kumhlahlandlela we-FDA wango-2021 mayelana nokuhanjiswa kwe-ANDA kwezidakamizwa ze-peptide zokwenziwa ezihlanzekile.

Indlela Yokwenza

I-Semaglutide ilingisa i-GLP-1 yomuntu, i-incretin hormone edlala indima ebalulekile kumetabolism ye-glucose. Isebenza ngezindlela eziningi ze-synergistic:

  • Ikhuthaza ukukhiqizwa kwe-insulinngendlela encike ku-glucose

  • Ivimbela ukukhiqizwa kwe-glucagon, yehlisa ukuphuma kwe-glucose ku-hepatic

  • Ibambezela ukuphuma kwesisu, okuholela ekulawuleni okuthuthukisiwe kwe-postprandial glycemic

  • Yehlisa isifiso sokudla kanye nokudla amandla, ukusekela ukulahlekelwa isisindo

Imiphumela Yomtholampilo

Izifundo ezibanzi zemitholampilo (isb, i-SUSTAIN ne-STEP izivivinyo) zibonise ukuthi i-Semaglutide:

  • Yehlisa kakhulu i-HbA1c kanye nezinga le-glucose esheshayo ezigulini ezinesifo sikashukela sohlobo 2

  • Ikhuthaza ukwehla kwesisindo esiningi nokuqhubekayo kubantu abakhuluphele noma abakhuluphele

  • Yehlisa izimpawu zengozi yenhliziyo nemithambo yegazi njengomfutho wegazi nokuvuvukala

Ngephrofayili yokuphepha evumayo kanye nezinzuzo ezibanzi ze-metabolic, i-Semaglutide isiphenduke i-GLP-1 RA yomugqa wokuqala kushukela kanye nokwelapha okulwa nokukhuluphala. Inguqulo yethu ye-API igcina ukwethembeka kwesakhiwo okuphezulu kanye namazinga aphansi okungcola (≤0.1% ukungcola okungaziwa kwe-HPLC), iqinisekisa ukuvumelana okuhle kakhulu kwezemithi.

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