REVERSE T3 for protein synthesis, thermoregulation, energy production and regulation
Imininingwane Yomkhiqizo
| Igama | REVERSE T3 |
| Inombolo ye-CAS | 5817-39-0 |
| Ifomula yamangqamuzana | I-C15H12I3NO4 |
| Isisindo samangqamuzana | 650.97 |
| Iphoyinti lokuncibilika | 234-238°C |
| Iphuzu elibilayo | 534.6±50.0°C |
| Ubumsulwa | 98% |
| Isitoreji | Gcina endaweni emnyama, Valwe endaweni eyomile, Gcina efrijini, ngaphansi kuka-20°C |
| Ifomu | Impushana |
| Umbala | I-Pale Beige kuya ku-Brown |
| Ukupakisha | Isikhwama se-PE+Isikhwama se-Aluminium |
Omqondofana
ReverseT3(3,3',5'-Triiodo-L-Thyronine);L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-;(2S) -2-aMino-3-[4-(4-hydroxy-3,5-diiodophe) noxy)-3-iodophenyl]propanoicacid;REVERSET3;T3;LIOTHYRONIN;L-3,3',5'-TRIIODOTHYRONINE;3,3′,5′-Triiodo-L-thyronine(ReverseT3)isixazululo
I-Pharmacological Effect
Incazelo
Indlala yegilo iyindlala enkulu ye-endocrine emzimbeni womuntu, futhi izinto ezisebenzayo eziyinhloko i-tetraiodothyronine (T4) ne-triiodothyronine (T3), ezibaluleke kakhulu ekuhlanganiseni amaprotheni, ukulawula izinga lokushisa lomzimba, ukukhiqizwa kwamandla kanye nendima yokulawula. Iningi le-T3 ku-serum liguqulwa lisuka ku-peripheral tissue deiodination, futhi ingxenye encane ye-T3 ikhishwa ngokuqondile yi-thyroid futhi ikhishwe egazini. Iningi le-T3 ku-serum liboshelwe kumaprotheni abophayo, cishe u-90% wawo oboshwe ku-thyroxine-binding globulin (TBG), enye iboshelwe ku-albumin, kanti inani elincane kakhulu liboshelwe ku-thyroxine-binding prealbumin (TBPA). Okuqukethwe kwe-T3 ku-serum yi-1/80-1/50 yaleyo ye-T4, kodwa umsebenzi webhayoloji we-T3 uphindwe izikhathi ezingu-5-10 kune-T4. I-T3 idlala indima ebalulekile ekwahluleleni isimo somzimba womuntu, ngakho kubaluleke kakhulu ukuthola okuqukethwe kwe-T3 ku-serum.
Ukubaluleka Komtholampilo
Ukunqunywa kwe-triiodothyronine kungenye yezinkomba ezibucayi zokuxilongwa kwe-hyperthyroidism. Lapho i-hyperthyroidism ikhula, iphinde ibe isandulela sokuphindaphinda kwe-hyperthyroidism. Ngaphezu kwalokho, izokhula futhi ngesikhathi sokukhulelwa kanye ne-hepatitis eyingozi. I-Hypothyroidism, i-goiter elula, i-nephritis eyingozi futhi engapheli, i-hepatitis engapheli, i-cirrhosis yesibindi yehla. I-Serum T3 concentration ikhombisa ukusebenza kwegland yegilo ezicutshini ezizungezile kunesimo sokuyimfihlo sendlala yegilo. Ukunqunywa kwe-T3 kungasetshenziselwa ukuxilongwa kwe-T3-hyperthyroidism, ukuhlonza i-hyperthyroidism yokuqala kanye nokuxilongwa kwe-pseudothyrotoxicosis. Isamba sezinga le-serum T3 ngokuvamile lihambisana nokushintsha kwezinga le-T4. Kuyinkomba ebucayi yokuxilongwa kokusebenza kwegilo, ikakhulukazi ekuxilongeni kusenesikhathi. Kuyinkomba ethile yokuxilonga ye-T3 hyperthyroidism, kodwa inenani elincane lokuxilongwa kokusebenza kwegilo. Ezigulini eziphathwa ngezidakamizwa ze-thyroid, kufanele zihlanganiswe ne-thyroxine (TT4) ephelele futhi, uma kunesidingo, i-thyrotropin (TSH) ngesikhathi esifanayo ukusiza ukwahlulela isimo sokusebenza kwe-thyroid.
