Imikhiqizo

Givosiran

I-Givosiran API iyi-RNA encane ephazamisayo yokwenziwa (siRNA) efundelwe ukwelashwa kwe-acute hepatic porphyria (AHP). Iqondise ngokuqondile i-I-ALAS1isakhi sofuzo (i-aminolevulinic acid synthase 1), ehilelekile endleleni ye-heme biosynthesis. Abacwaningi basebenzisa i-Givosiran ukuze baphenye izindlela zokwelapha ezisekelwe ku-RNA (RNAi), ukuthulisa izakhi zofuzo eziqondiswe esibindini, kanye nokuguqulwa kwemizila ye-metabolic ehilelekile ku-porphyria kanye nokuphazamiseka kofuzo okuhlobene.

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I-Pegcetacoplan

I-Pegcetacoplan iyipeptide ye-pegylated cyclic esebenza njenge-C3 complement inhibitor ehlosiwe, eyenzelwe ukwelashwa kwezifo ezihambisanayo ezifana ne-paroxysmal nocturnal hemoglobinuria (PNH) kanye ne-geographic atrophy (GA) ekuwohlokeni kwe-macular okuhlobene neminyaka.

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I-Plozasiran

I-Plozasiran API i-RNA encane ephazamisayo yokwenziwa (i-siRNA) eyenzelwe ukwelapha i-hypertriglyceridemia kanye nokuphazamiseka kwenhliziyo nemithambo yegazi okuhlobene. Ihlose iI-APOC3I-gene, ehlanganisa i-apolipoprotein C-III, isilawuli esiyinhloko se-triglyceride metabolism. Ocwaningweni, i-Plozasiran isetshenziselwa ukutadisha amasu okwehlisa i-lipid asuselwa ku-RNAi, ukucaciswa kokuthulisa izakhi zofuzo, kanye nokwelashwa okuthatha isikhathi eside ezimeni ezifana ne-familia chylomicronemia syndrome (FCS) kanye ne-dyslipidemia exubile.

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Zilebesiran

I-Zilebesiran API iyi-RNA encane ephazamisayo yophenyo (siRNA) eyenzelwe ukwelapha umfutho wegazi ophakeme. Ihlose iI-AGTisakhi sofuzo, esihlanganisa i-angiotensinogen—ingxenye eyinhloko yesistimu ye-renin-angiotensin-aldosterone (RAAS). Ocwaningweni, i-Zilebesiran isetshenziselwa ukutadisha izindlela zokuthulisa izakhi zofuzo zokulawula umfutho wegazi wesikhathi eside, ubuchwepheshe bokulethwa kwe-RNAi, kanye nendima ebanzi yomzila we-RAAS ezifweni zenhliziyo nemithambo yegazi.

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I-Palopegteriparatide

I-Palopegteriparatide iyi-agonist esebenza isikhathi eside ye-parathyroid hormone receptor (PTH1R agonist), eyenzelwe ukwelashwa kwe-hypoparathyroidism engapheli. Kuyi-analog ye-pegylated ye-PTH (1-34) eklanyelwe ukunikeza ukulawulwa kwe-calcium okuqhubekayo ngokudosa kanye ngeviki.

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I-GHRP-6

I-GHRP-6 (I-Growth Hormone Releasing Peptide-6) iyi-hexapeptide yokwenziwa esebenza njenge-secretagogue ye-hormone yokukhula, evuselela ukukhululwa kwemvelo komzimba kwe-hormone yokukhula (GH) ngokwenza kusebenze isamukeli se-GHSR-1a.

Izici ze-API :

Ukuhlanzeka ≥99%

Kwenziwe nge-solid-phase peptide synthesis (SPPS)

Ihlinzekelwe i-R&D nokusetshenziswa kwezentengiso

I-GHRP-6 iyi-peptide yocwaningo enemisebenzi eminingi yokusekelwa kwe-metabolic, ukuvuselelwa kwemisipha, nokuguqulwa kwamahomoni.

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I-GHRP-2

I-GHRP-2 (I-Growth Hormone Releasing Peptide-2) iyi-hexapeptide yokwenziwa kanye ne-hormone yokukhula enamandla secretagogue, eklanyelwe ukugqugquzela ukukhululwa kwemvelo kwe-hormone yokukhula (GH) ngokwenza kusebenze isamukeli se-GHSR-1a ku-hypothalamus kanye ne-pituitary.

Izici ze-API:

Ukuhlanzeka ≥99%

Itholakalela i-R&D kanye nokuhlinzekwa kwezentengiso, nemibhalo egcwele ye-QC

I-GHRP-2 iyi-peptide yocwaningo ebalulekile emikhakheni ye-endocrinology, imithi evuselelayo, kanye nokwelashwa okuhlobene nobudala.

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I-Hexarelin

I-Hexarelin iyi-hormone yokukhula yokwenziwa ye-secretagogue peptide (GHS) kanye ne-GHSR-1a agonist enamandla, ethuthukiswe ukugqugquzela ukukhululwa kwe-endogenous growth hormone (GH). Ingokomndeni we-ghrelin mimetic futhi yakhiwe ama-amino acid ayisithupha (i-hexapeptide), enikeza ukuzinza okuthuthukisiwe kwe-metabolic kanye nemiphumela eqinile yokukhulula i-GH uma kuqhathaniswa nama-analog angaphambilini afana ne-GHRP-6.

Izici ze-API :

Ukuhlanzeka ≥ 99%

Ikhiqizwe nge-solid-phase peptide synthesis (SPPS)

Amazinga afana ne-GMP, i-endotoxin ephansi nezinsalela ze-solvent

Ukunikezwa okuguquguqukayo: I-R&D kuya esikalini sezentengiso

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I-Melanotan II

Izici ze-API:
Ukuhlanzeka okuphezulu ≥ 99%
Ihlanganiswe nge-solid-phase peptide synthesis (SPPS)
I-endotoxin ephansi, izincibilikisi eziyinsalela ephansi
Itholakala nge-R&D kuya esikalini sezentengiso

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I-Melanotan 1
I-Melanotan 1 API ikhiqizwa kusetshenziswa ubuchwepheshe obuqinile besigaba se-peptide synthesis (SPPS) ngaphansi kwezimo eziqinile zokulawula ikhwalithi ezifana ne-GMP.

Ukuhlanzeka okuphezulu ≥99%

I-Solid-phase peptide synthesis (SPPS)

Amazinga okukhiqiza afana ne-GMP

Imibhalo egcwele: COA, MSDS, idatha yokuzinza

Ukunikezwa okulinganiswayo: I-R&D kuya kumaleveli ezohwebo
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I-MOTS-C

I-MOTS-C API ikhiqizwa ngaphansi kwezimo eziqinile ezifana ne-GMP kusetshenziswa ubuchwepheshe obuqinile besigaba se-peptide synthesis (SPPS) ukuze kuqinisekiswe izinga layo eliphezulu, ukuhlanzeka okuphezulu nokuzinza okuphezulu kocwaningo nokusetshenziswa kokwelapha.
Izici Zomkhiqizo:

Ubumsulwa ≥ 99% (kuqinisekiswe yi-HPLC ne-LC-MS),
I-endotoxin ephansi kanye nokuqukethwe kwe-solvent eyinsalela,
Ikhiqizwe ngokuhambisana ne-ICH Q7 kanye ne-GMP-like protocols,
Ingafinyelela ukukhiqizwa kwezinga elikhulu, kusukela kumaqoqwana e-R&D eleveli ye-milligram ukuya kwezinga legremu kanye neleveli yekhilogremu ukunikezwa kwezohwebo.

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I-Ipamorelin

I-Ipamorelin API ilungiswa nge-high-standard **inqubo ye-peptide synthesis yesigaba esiqinile (SPPS)** futhi ibhekana nokuhlanzwa okuqinile nokuhlolwa kwekhwalithi, okufanelekile ukusetshenziswa kwamapayipi okuqala ocwaningweni lwesayensi nokuthuthukiswa kanye nezinkampani zemithi.
Izici zomkhiqizo zifaka:
Ukuhlanzeka ≥99% (ukuhlolwa kwe-HPLC)
Ayikho i-endotoxin, i-solvent eyinsalela ephansi, ukungcoliswa kwe-ion yensimbi ephansi
Nikeza ngesethi ephelele yamadokhumenti ekhwalithi: I-COA, umbiko wocwaningo lokuzinza, ukuhlaziywa kwe-spectrum yokungcola, njll.
Ukunikezwa kweleveli yegremu ~kilogram-leveli okwenziwa ngokwezifiso

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