Imikhiqizo
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I-Ste-γ-Glu-AEEA-AEEA-OSU
I-Ste-γ-Glu-AEEA-AEEA-OSU iyingqamuzana yokwenziwa ye-lipidated linker eyenzelwe ukulethwa kwezidakamizwa okuhlosiwe kanye nama-antibody–drug conjugates (ADCs). Ifaka umsila we-stearoyl (Ste) we-hydrophobic, i-γ-glutamyl eqondiwe motif, izikhala ze-AEEA zokuguquguquka, kanye neqembu le-OSu (NHS ester) lokuhlanganisa kahle.
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Fmoc-Ile-αMeLeu-Leu-OH
I-Fmoc-Ile-αMeLeu-Leu-OH iyisakhiwo sokwenziwa esivikelwe se-tripeptide esine-α-methylated leucine, evame ukusetshenziswa ekwakhiweni kwezidakamizwa ze-peptide ukuze kuthuthukiswe ukuzinza kwe-metabolic kanye nokukhetha kwe-receptor.
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I-Dodecyl Phosphocholine (DPC)
I-Dodecyl Phosphocholine (DPC) isihlanzi sokwenziwa se-zwitterionic esisetshenziswa kakhulu ocwaningweni lwamaprotheni e-membrane kanye ne-structural biology, ikakhulukazi ku-NMR spectroscopy kanye ne-crystallography.
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I-N-Acetylneuraminic Acid(Neu5Ac Sialic Acid)
I-N-Acetylneuraminic Acid (Neu5Ac), evame ukwaziwa nge-sialic acid, iyi-monosaccharide eyenzeka ngokwemvelo ebandakanyeka emisebenzini ebalulekile yamaselula neyokuzivikela komzimba. Idlala indima ebalulekile ekuboniseni amaseli, ukuvikela i-pathogen, nokuthuthukiswa kobuchopho.
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I-Ergothioneine
I-Ergothioneine iyi-antioxidant etholakala ngokwemvelo ku-amino acid, efundelwe izici zayo ezinamandla ze-cytoprotective kanye nezokulwa nokuguga. Ihlanganiswa yisikhunta namagciwane futhi inqwabelane ezicutshini ezichayeke ekucindezelekeni kwe-oxidative.
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NMN
Ucwaningo lwangaphambi komtholampilo kanye nolwasekuqaleni kwabantu luphakamisa ukuthi i-NMN ingase ikhuthaze ukuphila isikhathi eside, ukukhuthazela ngokomzimba, nokusebenza kwengqondo.
Izici ze-API:
Ukuhlanzeka okuphezulu ≥99%
Ibanga lezemithi, elilungele ukwakheka ngomlomo noma okujovwayo
Kwenziwe ngaphansi kwamazinga afana ne-GMP
I-NMN API ilungele ukusetshenziswa ezithasiselweni zokulwa nokuguga, ukwelashwa kwe-metabolic, kanye nocwaningo lwempilo ende.
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IGlucagon
I-Glucagon iyi-hormone yemvelo ye-peptide esetshenziswa njengokwelashwa okuphuthumayo kwe-hypoglycemia enzima futhi yafundelwa indima yayo ekulawuleni i-metabolic, ukuncipha kwesisindo, kanye nokuxilongwa kokugaya ukudla.
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I-Motixafortide
I-Motixafortide iyi-peptide yokwenziwa ye-CXCR4 ephikisanayo eyenzelwe ukuhlanganisa amangqamuzana e-hematopoietic stem (HSCs) ukuze kufakwe i-autologous transplantation futhi iyacwaningwa ku-oncology kanye ne-immunotherapy.
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I-Glepaglutide
I-Glepaglutide iyi-analog esebenza isikhathi eside ye-GLP-2 eyenzelwe ukwelapha i-short bowel syndrome (SBS). Ithuthukisa ukumuncwa nokukhula kwamathumbu, kusize iziguli zehlise ukuncika ekondlekeni kwabazali.
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I-Elamipretide
I-Elamipretide iyi-tetrapeptide ehloselwe i-mitochondria eyenzelwe ukwelapha izifo ezibangelwa ukungasebenzi kahle kwe-mitochondrial, okuhlanganisa i-mitochondrial myopathy eyinhloko, i-Barth syndrome, nokuhluleka kwenhliziyo.
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I-Donidalorsen
I-Donilorsen API iyi-antisense oligonucleotide (ASO) ephenywayo yokwelashwa kwe-angioedema yofuzo (HAE) kanye nezimo zokuvuvukala ezihlobene. Kufundwa kumongo wezindlela zokwelapha eziqondiswe ku-RNA, okuhloswe ngazo ukunciphisa ukubonakaliswa kwei-plasma prekallikrein(KLKB1 mRNA). Abacwaningi basebenzisa i-Donidalorsen ukuhlola izindlela zokuthulisa izakhi zofuzo, i-pharmacokinetics encike kumthamo, kanye nokulawulwa kwesikhathi eside kokuvuvukala okuhambisana ne-bradykinin.
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I-Fitusiran
I-Fitusiran API iyi-RNA encane ephazamisayo (siRNA) ephenywa ngokuyinhloko emkhakheni we-hemophilia kanye nokuphazamiseka kwe-coagulation. Ihlose ii-antithrombin (AT noma i-SERPINC1)isakhi sofuzo esibindini ukunciphisa ukukhiqizwa kwe-antithrombin. Abacwaningi basebenzisa i-Fitusiran ukuhlola izindlela zokuphazanyiswa kwe-RNA (i-RNAi), ukuthulisa izakhi zofuzo ezithize esibindini, kanye namasu anoveli okwelapha okubuyisela ukulinganisa ukuhlangana ezigulini ze-hemophilia A no-B, ezinama-inhibitors noma ngaphandle kwazo.