Imikhiqizo

I-CJC-1295

I-CJC-1295 API ikhiqizwa kusetshenziswa ubuchwepheshe obuqinile besigaba se-peptide synthesis (SPPS) futhi ihlanzwa kusetshenziswa i-HPLC ukuze kuzuzwe ukuhlanzeka okuphezulu kanye nokuvumelana kwe-batch-to-batch.
Izici Zomkhiqizo:

Ukuhlanzeka ≥ 99%

Izincibilikisi ezisalela eziphansi nezinsimbi ezisindayo

Umzila we-endotoxin-free, non-immunogenic synthesis

Amanani enziwe ngendlela oyifisayo: mg ukuya ku-kg

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NAD+

Izici ze-API:

Ukuhlanzeka okuphezulu ≥99%

I-NAD+ yezinga lezemithi

Amazinga okukhiqiza afana ne-GMP

I-NAD+ API ilungele ukusetshenziswa kuma-nutraceuticals, imijovo, kanye nokwelapha okuthuthukisiwe kwe-metabolic.

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I-Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OH

I-Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OHiyi-tetrapeptide evikelwe evame ukusetshenziswa ocwaningweni lwe-peptide synthesis. Amaqembu e-Boc (tert-butyloxycarbonyl) kanye ne-tBu (tert-butyl) asebenza njengamaqembu avikelayo ukuze avimbele ukusabela okuseceleni ngesikhathi sokuhlanganisa iketango le-peptide. Ukufakwa kwe-Aib (α-aminoisobutyric acid) kusiza ukuheha izakhiwo ze-helical futhi kwandise ukuzinza kwe-peptide. Lokhu kulandelana kwe-peptide kuhlolwa amandla ako ekuhlaziyeni okuvumelanayo, ukugoqa i-peptide, nanjengesakhiwo sokwakha ama-peptide e-bioactive ngokuzinza nokucaciswa okuthuthukisiwe.

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I-Cagrilintide

I-Cagrilintide iwukwenziwa, i-amylin receptor agonist yokwenziwa isikhathi eside eyenzelwe ukwelapha ukukhuluphala kanye nokuphazamiseka kwe-metabolic okuhlobene nesisindo. Ngokulingisa i-hormone yemvelo i-amylin, isiza ukulawula isifiso sokudla, ukuphuma kancane kwesisu, nokuthuthukisa ukusutha. I-high-purity API ye-Cagrilintide ikhiqizwa ngokusebenzisa amakhemikhali futhi ihlangabezana nezindinganiso zebanga lezemithi, okuyenza ifanelekele ukusetshenziswa ekwakhiweni kokulawulwa kwesisindo okuthuthukisiwe.

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I-Tesamorelin

I-Tesamorelin API isebenzisa ubuchwepheshe obuthuthukisiwe besigaba se-peptide synthesis (SPPS) futhi inezici ezilandelayo:

Ubumsulwa ≥99% (HPLC)
Awekho ama-endotoxin, izinsimbi ezisindayo, izincibilikisi eziyinsalela ezihloliwe
Ukulandelana kwe-amino acid nesakhiwo kuqinisekiswe yi-LC-MS/NMR
Nikeza ukukhiqizwa okwenziwe ngezifiso ngamagremu kuya kumakhilogremu

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Fmoc-Ile-Aib-OH

I-Fmoc-Ile-Aib-OH iyibhulokhi yokwakha ye-dipeptide esetshenziswa ku-solid-phase peptide synthesis (SPPS). Ihlanganisa i-isoleucine evikelwe i-Fmoc ne-Aib (i-α-aminoisobutyric acid), i-amino acid engeyona yemvelo ethuthukisa ukuzinza kwe-helix kanye nokumelana ne-protease.

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I-Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

I-Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH iyibhulokhi yokwakha esebenzayo ye-amino acid eklanyelwe ukulethwa kwezidakamizwa okuhlosiwe kanye ne-bioconjugation. Ifaka ingxenye ye-Eic (eicosanoid) yokusebenzisana kwe-lipid, i-γ-Glu yokukhomba, kanye nezikhala ze-AEEA zokuguquguquka.

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I-Boc-Tyr(tBu)-Aib-OH

I-Boc-Tyr(tBu)-Aib-OH iyibhulokhi yokwakha ye-dipeptide evikelwe esetshenziswa ekuhlanganiseni kwe-peptide, ehlanganisa i-Boc-protected tyrosine ne-Aib (α-aminoisobutyric acid). Izinsalela ze-Aib zithuthukisa ukwakheka kwe-helix kanye nokumelana ne-protease.

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I-Boc-His(Trt)-Ala-Glu(OtBu)-Gly-OH

I-Boc-His(Trt)-Ala-Glu(OtBu)-Gly-OH iyingxenye evikelwe ye-tetrapeptide esetshenziswa ekuhlanganiseni kwe-peptide synthesis yesigaba esiqinile (SPPS) kanye nokuthuthukiswa kwezidakamizwa ze-peptide. Kuhlanganisa namaqembu okuvikela e-orthogonal synthesis futhi ihlanganisa ukulandelana okuwusizo ekwakhiweni kwe-peptide ye-bioactive kanye nesakhiwo.

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I-Fmoc-Ls(Pal-Glu-OtBu)-OH

I-Fmoc-Ls(Pal-Glu-OtBu)-OH iyibhulokhi elikhethekile lokwakha i-amino acid elakhelwe ukuhlangana kwe-peptide-lipid. Ifaka i-lysine evikelwe nge-Fmoc enochungechunge oluseceleni lwe-palmitoyl-glutamate, ethuthukisa ukuhlangana kwe-membrane kanye nokuba khona kwe-bioavailability.

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Fmoc-His-Aib-OH

I-Fmoc-His-Aib-OH iyibhulokhi yokwakha ye-dipeptide esetshenziswa ekuhlanganiseni kwe-peptide, ehlanganisa i-Fmoc-protected histidine ne-Aib (α-aminoisobutyric acid). I-Aib yethula ukuqina kwe-conformational, ikwenze kube wusizo ekuklameni ama-peptide e-helical nezinzile.

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I-Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH

I-Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH iyingxenye evikelwe ye-tetrapeptide esetshenziswa ekuhlanganiseni kwe-peptide nokuthuthukiswa kwezidakamizwa. Iqukethe amaqembu asebenzayo avikelwe ngendlela ehlelekile ukuze kuhlanganiswe isinyathelo futhi ifake i-Aib (α-aminoisobutyric acid) ukuze kuthuthukiswe ukuqina kwe-helix kanye nokuqina kwe-conformational.

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