I-Pregabalin yokwelashwa kwe-peripheral neullouralgia kanye nokwelashwa okuhlangene kokuhlaselwa okuyingxenye kwasendaweni

Umphumela wekhemisi
I-Pregabalin inomphumela omuhle wezokwelapha esithuthwaneni. Izifundo kumamodeli ahlukahlukene wezilwane ezibangelwa izilwane ezifuyile. Ucwaningo luthole ukuthi i-pregabalin inganciphisa ikhambi lemizwa nezimoto zomgogodla we-rat pinch-toe ukugqugquzela amamodeli wesifo sikashukela, ukulimala kwezinzwa zezinzwa noma ukuvimba noma ukunciphisa noma kunciphise izinhlungu ezihlobene nobuhlungu Isikhuthazo esimnandi. indlela yokuziphatha. Izifundo zezilwane zithole ukuthi uPregabalin angaba nezinzuzo ngokuhlanganiswa nama-opioids. I-Pregabalin ihlinzeka ngenketho entsha yokwelashwa kwemitholampilo kobuhlungu be-neuropathic.

Umshini
I-Pregabalin inganciphisa ukukhishwa okuncike ku-calcium kwamanye ama-neurotransmitters ngokuguqula umsebenzi wesiteshi se-calcium. Yize i-pregabalin ingukususwa kwesakhiwo kwe-neurotransmitic ye-neurotransmic acid-Gaba), ayihlanganisi ngokuqondile eGabaa, iGabab, noma iBenzodiazepine receptors futhi ayikhuphuli ukusabela kwe-neurons, ayiguquli ukugcwala kwe-GABA ku Ubuchopho bamagundane, futhi awunawo umphumela onzima ekuthandeni kwe-Gaba noma ukucekelwa phansi. Kodwa-ke, isifundo sathola ukuthi ukuvezwa isikhathi eside kwama-neurons abunjiwe ku-pregabalin kwandise ubukhulu babathutha beGABA kanye nezinga lokuhamba kwezinga elisebenzayo le-GABA. I-Pregabalin ayivimbi iziteshi ze-soodium, ayinawo umsebenzi kuma-opioid receptors, ayiguquki umsebenzi we-cyclooxygenase, ayinawo umsebenzi ku-dopamine nase-serotonin receptors, futhi ayivimbeli ukuvuselelwa kwe-dopamine, i-serotonin, noma i-norepinephrine. ukungenisa.

Ukusebenzisana Kwezokwelapha
1. Akukaze kuhlaselwe uhlelo lwe-cytochrome P450 uhlelo, ngakho-ke, akuvamile ukuxhumana nezinye izidakamizwa. Akuthinti ama-pharmacokinetics ama-antiepileptic izidakamizwa (njenge-sodium valproate, i-phenytoin, i-lamotrigine, i-carbazepine, i-photoglycec, ama-topirecote), ama-diuretics, ama-diuretics, ne-diuretics, ne-insulelin.
2. Lapho lo mkhiqizo usetshenziswa ndawonye nge-oxycodone, umsebenzi wawo wokuqashelwa uzoncishiswa futhi ukulimala komsebenzi wezimoto kuzothuthukiswa.
I-3. Inomphumela wesengezo noLorazepam ne-ethanol.